A new proposition for the screening of platelet function defects using an hematology analyzer

Bennaoum, Mohammed Nazim; Lazreg, Hassiba; Adda, Affaf; Hammadi, Mohamed

doi:10.1016/j.mehy.2017.02.005

Cited by 3 publications

(2 citation statements)

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“…Morphological abnormalities of peripheral blood cells, such as false Pelger nuclear neutrophils, degranulated neutrophils, poikilocytes, and degranulated giant platelets, are often found in peripheral blood smears from MDS patients . Given that these abnormal peripheral blood cells may be derived from abnormal bone marrow cells in MDS patients, morphological abnormalities of the cellular components of the peripheral blood may provide clues for diagnosing MDS.…”

Section: Introductionmentioning

confidence: 99%

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Mean platelet component and mean platelet volume as useful screening markers for myelodysplastic syndrome

Masutani

Ikemoto

Maki

et al. 2018

Health Science Reports

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BackgroundHematologic disorders, including myelodysplastic syndrome (MDS), are difficult to identify in routine hematologic examinations using automated hematology analyzers. However, the practical uses of mean platelet component and mean platelet volume (MPV) measured by these analyzers as screening markers for MDS, remain unclear.MethodsMean platelet component and MPV values were measured in the peripheral blood of patients with MDS, aplastic anemia, idiopathic thrombocytopenic purpura, myeloproliferative neoplasms, and in healthy controls using an automated hematologic analyzer. Cutoff values for discriminating between the MDS group and healthy controls were determined by recursive partitioning analysis.ResultsMean platelet component was significantly lower in MDS patients compared with controls, while MPV was significantly higher. Combined cutoff values for MDS diagnosis of <25.3 g/dL for mean platelet component and >10.0 fL for MPV showed a specificity and positive predictive value of 99.9% and 99.1%, respectively. These cutoff values also differentiated between MDS and diagnoses of aplastic anemia, idiopathic thrombocytopenic purpura, and myeloproliferative neoplasms.ConclusionMean platelet component and MPV may, thus, be useful and convenient screening markers for MDS.

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Section: Introductionmentioning

confidence: 99%

“…peripheral blood smears from MDS patients. 3 Given that these abnormal peripheral blood cells may be derived from abnormal bone marrow cells in MDS patients, morphological abnormalities of the cellular components of the peripheral blood may provide clues for diagnosing MDS.…”

mentioning

confidence: 99%