Adverse Testicular Effects of Some Quinolone Members in Rats

Abd-Allah, Adel R. A.; Aly, Hamdy A.A.; Moustafa, Adel M.; Abdel-Aziz, Abdel-Aziz H.; Hamada, Farid M.A.

doi:10.1006/phrs.1999.0580

Cited by 40 publications

(31 citation statements)

References 34 publications

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“…In the absence of significant synergistic decrease in sperm count when these agents were co-administered the concurrent use of these agents may be safe on testicular function. Decrease in sperm count by these agents may be attributed to damage to leydig cells and seminiferous tubules responsible for testosterone and sperm production respectively [48].…”

Section: Discussionmentioning

confidence: 99%

Impact of Co-administered Lopinavir/Ritonavir and Sulfamethoxazole/Trimethoprim on Reproductive Indices of Male Albino Rats

Oputiri¹,

Adikwu²

2014

AJPS

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Antiretroviral drugs containing Lopinavir/ ritonavir (LPV/r) are usually co-administered with sulfamethoxazole / trimethoprim (SMX/TMP) in the management of HIV/AIDS and co infections. The concurrent use of these drugs may place more adverse burden on testicular function because reports have associated these drugs individually with decreased testicular function. This study therefore evaluated the effects of the co-administration of SMX/TMP + LPV/r on reproductive indices of male albino rats. Eighty (80) adult male rats which were divided into five (5) groups A-E were used in this study. Animals in group A which served as the control were treated with 1% ethanol while animals in groups B-E were treated orally with SMX/TMP, (22.4/4.6mg/kg), LPV/r (22.8/5.8mg/kg) and combined doses of SMX/TMP + LPV/r for 2-8 weeks respectively. Animals were sacrificed at the end of treatment, testes were collected and weighed. Sperm count, sperm motility, and morphology were evaluated. Testicular levels of malondialdehyde (MDA), super oxide dismutase (SOD) and histopathological changes were also analyzed. Single doses of LPV/r and SMX/TMP produced significant time dependent decrease in total sperm count and sperm motility, with increase in abnormal sperm morphology. Treatment with single doses of these agents time dependently increased testicular MDA, decreased SOD level and induced abnormal testicular histopathological changes. No significant synergistic effects were observed in all evaluated parameters when these agents were coadministered. Conclusion: Due to lack of significant synergistic effects on all evaluated parameters with the coadministration of these agents, the concurrent use of these agents in the management of HIV and co-infections may not have any deleterious effect on male reproductive function.

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Section: Discussionmentioning

confidence: 99%

Impact of Co-administered Lopinavir/Ritonavir and Sulfamethoxazole/Trimethoprim on Reproductive Indices of Male Albino Rats

Oputiri¹,

Adikwu²

2014

AJPS

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“…Twenty‐four male Sprague–Dawley rats (6 months old, 300–350 g) were divided into four groups: Control group (group 1) did not undergo any intervention. Group 2 received oral ciprofloxacin (obtained in powder form from Dr Reddy's Laboratory, Pradsh, India) via a stomach tube in once daily doses of 150 mg/kg bodyweight for 10 days, treatment dose prepared to imitate the human therapeutic dose 3 . EO was induced in group 3 by injecting 0.1 mL Escherichia coli suspension (10 6 cfu/mL, ATCC 25922, Oxoid, Hampshire, UK) into the epididymal direction of the proximal right vas deferens as described previously 4 .…”

Section: Methodsmentioning

confidence: 99%

“…In vivo genotoxicity studies suggest ciprofloxacin as safe for therapeutic use 2 . However, other studies have demonstrated ciprofloxacin to significantly impair both testicular function and structure 3 . In this study, we investigated the effects of ciprofloxacin treatment on testicular morphology and spermatogenesis in a rat EO model.…”

Section: Introductionmentioning

confidence: 96%

Effect of experimentally induced Escherichia coli epididymo‐orchitis and ciprofloxacin treatment on rat spermatogenesis

Demir¹,

Türker²,

Önol³

et al. 2007

Int J of Urology

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Abstract:We investigated the effects of epididymo-orchitis and ciprofloxacin on rat testicular histology and spermatogenesis. The control group underwent left orchiectomy. The second group received oral ciprofloxacin (150 mg/kg/day) for 10 days. Escherichia coli (10 6 cfu/mL, 0.1 mL) was injected into the proximal right ductus deferens in the third group. The fourth group received ciprofloxacin treatment 48 h after E. coli inoculation. In groups 3 and 4, bilateral orchiectomy was performed 14 days after the challenge. In healthy rats, ciprofloxacin caused recognizable histological damage associated with a mild decrease in testicular volume and sperm concentration. Infected testicles in groups 3 and 4 revealed severe histological damage associated with severe testicular atrophy and impaired spermatogenesis that were more significant in infected rats which received ciprofloxacin treatment. Contralateral testicles in these animals showed similar histopathological changes to a lesser extent. The results of our study suggest a gonadotoxic potential for ciprofloxacin and this potential in humans should be addressed with further studies.

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“…This side effect has not yet been directly shown in humans by randomized clinical trials, but there are data concerning testicular and/or sperm toxicity for some antibiotics in rats or mice. These include ciprofloxacin and pefloxacin [36], ofloxacin [37], lomefloxacin [38], tetracyclines [39], cefonicid and other cephalosporins [40], and norfloxacin in quails [41]. …”

Section: Antibiotic Treatmentmentioning

confidence: 99%

Conservative Nonhormonal Options for the Treatment of Male Infertility: Antibiotics, Anti-Inflammatory Drugs, and Antioxidants

Calogero

Condorelli

Russo

et al. 2017

BioMed Research International

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The nonhormonal medical treatment can be divided into empirical, when the cause has not been identified, and nonempirical, if the pathogenic mechanism causing male infertility can be solved or ameliorated. The empirical nonhormonal medical treatment has been proposed for patients with idiopathic or noncurable oligoasthenoteratozoospermia and for normozoospermic infertile patients. Anti-inflammatory, fibrinolytic, and antioxidant compounds, oligo elements, and vitamin supplementation may be prescribed. Infection, inflammation, and/or increased oxidative stress often require a specific treatment with antibiotics, anti-inflammatory drugs, and/or antioxidants. Combined therapies can contribute to improve sperm quality.

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Adverse Testicular Effects of Some Quinolone Members in Rats

Cited by 40 publications

References 34 publications

Impact of Co-administered Lopinavir/Ritonavir and Sulfamethoxazole/Trimethoprim on Reproductive Indices of Male Albino Rats

Impact of Co-administered Lopinavir/Ritonavir and Sulfamethoxazole/Trimethoprim on Reproductive Indices of Male Albino Rats

Effect of experimentally induced Escherichia coli epididymo‐orchitis and ciprofloxacin treatment on rat spermatogenesis

Conservative Nonhormonal Options for the Treatment of Male Infertility: Antibiotics, Anti-Inflammatory Drugs, and Antioxidants

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