Conservative Nonhormonal Options for the Treatment of Male Infertility: Antibiotics, Anti-Inflammatory Drugs, and Antioxidants

Calogero, Aldo E.; Condorelli, Rosita A.; Russo, Giorgio Ivan; Vignera, Sandro La

doi:10.1155/2017/4650182

Cited by 64 publications

(47 citation statements)

References 141 publications

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“…The administration of vitamin E (alpha‐tocopherol), a potent antioxidant (Calogero et al., ), showed a beneficial effect on spermatozoon by protecting the acrosome and improving mitochondrial activity. Vitamin E has been shown to react with free radicals producing the alpha‐tocopherol radical.…”

Section: Discussionmentioning

confidence: 99%

“…It is already known that in vitro supplementation can improve sperm viability and motility (Aitken et al., ; Burton & Ingold, ; Ribas‐Maynou et al., ). One of the main antioxidants utilised is vitamin E (Burton & Ingold, ) which has a high antioxidant capacity and has been utilised as a suggested nonhormonal treatment in cases of male infertility (Calogero, Condorelli, Russo, & La Vignera, ) and is an abundant nonenzymatic antioxidant (Zhou et al., ) that acts by reaction with free radicals, suffering oxidation in the place of other molecules, thus neutralising the existing free radicals in samples and interrupting the oxidative cascade (Ouchi, Nagaoka, Abe, & Mukai, ).…”

Section: Introductionmentioning

confidence: 99%

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Effect of in vitro vitamin E (alpha-tocopherol) supplementation in human spermatozoon submitted to oxidative stress

et al. 2018

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The aim of this study was to evaluate the antioxidant effect of in vitro supplementation with vitamin E in human spermatozoon incubated with an oxidative stress inducer. In this study, semen samples from 30 patients were collected and with one aliquot we performed semen analysis according to WHO. The remaining volume was divided into four aliquots: group C: incubated with BWW medium; group I: incubated with 5 mmol 1-1 hydrogen peroxide; group A: incubated with 40 μmol 1-1 vitamin E; and group AI: incubated with both them. After incubations, sperm functional analyses were performed and included: evaluation of oxidative stress, acrosome integrity, mitochondrial activity and DNA fragmentation. Groups were compared using a Friedman test with Bonferroni post hoc (α = 5%). In this study, we observed that in group I there was a decrease in acrosome integrity and mitochondrial activity, and an increase in DNA fragmentation, when compared to group C. Group AI showed an increase in acrosome integrity and mitochondrial activity when compared with group I. Based on our findings, we conclude that the vitamin E supplementation had a positive effect in protecting human spermatozoon from induced oxidative stress.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of in vitro vitamin E (alpha-tocopherol) supplementation in human spermatozoon submitted to oxidative stress

et al. 2018

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“…Finally, differentiated spermatozoa are highly specialized cells that must be capable of active motility to get into the female genital tract and penetrate the oocyte. Due to the limited sperm scavenger capacity and sperm's well-known susceptibility to reactive oxygen species (ROS)-induced damage, all environmental factors leading to a perturbation of the pro-and anti-oxidant balance can potentially interfere with the sperm fertilization capacity [11,12].…”

Section: Physiology Of Spermatogenesismentioning

confidence: 99%

Molecular Biology of Spermatogenesis: Novel Targets of Apparently Idiopathic Male Infertility

Cannarella

Condorelli

Mongioì

et al. 2020

IJMS

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Male infertility affects half of infertile couples and, currently, a relevant percentage of cases of male infertility is considered as idiopathic. Although the male contribution to human fertilization has traditionally been restricted to sperm DNA, current evidence suggest that a relevant number of sperm transcripts and proteins are involved in acrosome reactions, sperm-oocyte fusion and, once released into the oocyte, embryo growth and development. The aim of this review is to provide updated and comprehensive insight into the molecular biology of spermatogenesis, including evidence on spermatogenetic failure and underlining the role of the sperm-carried molecular factors involved in oocyte fertilization and embryo growth. This represents the first step in the identification of new possible diagnostic and, possibly, therapeutic markers in the field of apparently idiopathic male infertility.

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“…Given the role of male semen infection, we suggest that more common testing of semen for infection is warranted, especially using molecular tests. Our analyses suggest that antibiotics might also be of benefit to those males presenting with high microbial semen loads or poor fertility [783]. Another strategy might involve stimulating the production of antimicrobial peptides in semen.…”

Section: Treatment Options Based On (Or Consistent With) the Ideas Prmentioning

confidence: 90%

Immunological tolerance, pregnancy and pre-eclampsia: the roles of semen microbes and the father¹

Kenny

Kell

2017

Preprint

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Although it is widely recognised as involving two stages (poor placentation followed by oxidative stress/inflammation), the precise originating causes of pre-eclampsia (PE) remain elusive. We have previously brought together some of the considerable evidence that a (dormant) microbial component is commonly a significant part of its aetiology. However, apart from recognising, consistent with this view, that the many inflammatory markers of PE are also increased in infection, we had little to say about immunity, whether innate or adaptive. In addition, we focussed on the gut, oral and female urinary tract microbiomes as the main sources of the infection. We here marshall further evidence for an infectious component in PE, focussing on the immunological tolerance characteristic of pregnancy, and the well-established fact that increased exposure to the father’s semen assists this immunological tolerance. As well as these benefits, however, semen is not sterile, microbial tolerance mechanisms may exist, and we also review the evidence that semen may be responsible for inoculating the developing conceptus with microbes, not all of which are benign. It is suggested that when they are not, this may be a significant cause of preeclampsia. A variety of epidemiological and other evidence is entirely consistent with this, not least correlations between semen infection, infertility and PE. Our view also leads to a series of other, testable predictions. Overall, we argue for a significant paternal role in the development of PE through microbial infection of the mother via insemination. “In one of the last articles which he wrote, the late Professor F J Browne (1958) expressed the opinion that all the essential facts about pregnancy toxaemia are now available and that all that is required to solve the problem is to fit them together in the right order, like the pieces of a jigsaw puzzle” [1]“It appears astonishing how little attention has been given in reproductive medicine to the maternal immune system over the last few decades.” [2]

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Conservative Nonhormonal Options for the Treatment of Male Infertility: Antibiotics, Anti-Inflammatory Drugs, and Antioxidants

Cited by 64 publications

References 141 publications

Effect of in vitro vitamin E (alpha-tocopherol) supplementation in human spermatozoon submitted to oxidative stress

Effect of in vitro vitamin E (alpha-tocopherol) supplementation in human spermatozoon submitted to oxidative stress

Molecular Biology of Spermatogenesis: Novel Targets of Apparently Idiopathic Male Infertility

Immunological tolerance, pregnancy and pre-eclampsia: the roles of semen microbes and the father¹

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Conservative Nonhormonal Options for the Treatment of Male Infertility: Antibiotics, Anti-Inflammatory Drugs, and Antioxidants

Cited by 64 publications

References 141 publications

Effect of in vitro vitamin E (alpha-tocopherol) supplementation in human spermatozoon submitted to oxidative stress

Effect of in vitro vitamin E (alpha-tocopherol) supplementation in human spermatozoon submitted to oxidative stress

Molecular Biology of Spermatogenesis: Novel Targets of Apparently Idiopathic Male Infertility

Immunological tolerance, pregnancy and pre-eclampsia: the roles of semen microbes and the father1

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Immunological tolerance, pregnancy and pre-eclampsia: the roles of semen microbes and the father¹