Adverse Reactions to Sunscreen Agents

Heurung, Ashley R.; Raju, Srihari; Warshaw, Erin M.

doi:10.1097/der.0000000000000079

Cited by 81 publications

(16 citation statements)

References 145 publications

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“…Patients with photodermatitis are likely to develop photo contact dermatitis to sunscreen. 83 Sunscreens containing p-amino benzoic acid (PABA) help to protect from UVB rays and is said to be water resistant. 42 But in vitro studies have shown that PABA interacts with DNA followed by UV radiations and might cause photocarcinogenesis.…”

Section: Toxicity Aspectsmentioning

confidence: 99%

Anti-aging and Sunscreens: Paradigm Shift in Cosmetics

et al. 2019

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Skin, being one of the vital organs and a protective barrier needs to be pampered and taken care of from early childhood. It is the most visible and the widest exposed organ and by far reflects the general health condition and the aging process in humans. Both intrinsic and extrinsic factors contribute to this complex biological process of skin aging. In recent times, skin health and its beauty is perceived as an indicator of one’s health which has resulted in an increasing demand for anti-aging products. Exposure to UV radiation is considered to be one of the factors responsible for aging termed as photoaging. In this review, we have discussed the various factors which may accelerate the process of skin aging. Various approaches and strategies to delay the process of skin aging have been emphasized upon. The patents filed in the area of anti-aging and sunscreen products have also been reviewed to gain an insight into the new formulations which have been developed as an anti-aging product. There has been a tremendous rise in the cosmetic and cosmeceuticals market with products having a dual activity of anti-aging and sun protection. Research is constantly on the rise to ensure the safety of these products. Alternatives to the current topical application of sunscreen are being considered to overcome the drawback of reapplication of the sunscreen often which can be a boon to the cosmeceutical market.

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Section: Toxicity Aspectsmentioning

confidence: 99%

Anti-aging and Sunscreens: Paradigm Shift in Cosmetics

et al. 2019

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“…As the molecule returns to the ground state, it releases the lower energy of longer wavelengths. [ 57 ] Such compounds as Avobenzone, Oxybenzone, Ecamsule, Octinoxate are FDA-approved components of topical sunscreens with different spectrums of absorption and various photostability. Octinoxate is identified as one of the potent UVB-absorbers [ 58 ], but is not photostable and degrades in the presence of sunlight after a short period of time, while Ecamsule, a very photostable product, acts as UVA-blocker.…”

Section: Resultsmentioning

confidence: 99%

“…The mechanism of action of physical sunscreens, such as Zinc oxide, Titanium dioxide is based on the reflection and scattering of UV light. The reflective properties - reflective index, the size of the particles, the film thickness, and the dispersion of base determine the effectiveness of inorganic sunscreens [ 57 ]. Microfine zinc oxide has shown to be efficient against a wide range of UVA including UVA 1 (340 to 400 nm), but less efficient in blocking UVB, compared to Titanium oxide.…”

Section: Resultsmentioning

confidence: 99%

Radioprotectors.org: an open database of known and predicted radioprotectors

Aliper

Bozdaganyan

Sarkisova

et al. 2020

Aging

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The search for radioprotectors is an ambitious goal with many practical applications. Particularly, the improvement of human radioresistance for space is an important task, which comes into view with the recent successes in the space industry. Currently, all radioprotective drugs can be divided into two large groups differing in their effectiveness depending on the type of exposure. The first of these is radioprotectors, highly effective for pulsed, and some types of relatively short exposure to irradiation. The second group consists of long-acting radioprotectors. These drugs are effective for prolonged and fractionated irradiation. They also protect against impulse exposure to ionizing radiation, but to a lesser extent than short-acting radioprotectors. Creating a database on radioprotectors is a necessity dictated by the modern development of science and technology. We have created an open database, Radioprotectors.org, containing an up-to-date list of substances with proven radioprotective properties. All radioprotectors are annotated with relevant chemical and biological information, including transcriptomic data, and can be filtered according to their properties. Additionally, the performed transcriptomics analysis has revealed specific transcriptomic profiles of radioprotectors, which should facilitate the search for potent radioprotectors.

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“…Sunscreens/ultraviolet filters (UV-filters) are mainly used in personal care products, such as lipsticks, perfumes, hairsprays, hair dye and moisturizers, skin care products, shampoos, and makeup, as well as in noncosmetic products, including furniture, plastics, carpets, and washing powder [ 104 , 105 ]. Sunscreens are popular protective products against ultraviolet radiation hazards, early skin aging, and skin cancer [ 106 ]. UV-filter formulations can be organic (chemicals) or inorganic (minerals) [ 107 ].…”

Section: Sunscreens/ultraviolet Filtersmentioning

confidence: 99%

“…Frederiksen et al investigated BP-3, a UV-filter, and found that it could be detected in 96% of American urine specimens and 85% of Swiss breast milk specimens analyzed [ 104 ]; however, UV-filter potential hazards on humans are difficult to assess using exposure data alone. At present, most case reports are related to dermatitis caused by sunscreens [ 106 ]. The associations between sunscreens and adverse effects on humans have not been deeply and widely investigated.…”

Section: Sunscreens/ultraviolet Filtersmentioning

confidence: 99%

Overview of Emerging Contaminants and Associated Human Health Effects

Meng

Zhang

Lei

et al. 2015

BioMed Research International

157

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In recent decades, because of significant progress in the analysis and detection of trace pollutants, emerging contaminants have been discovered and quantified in living beings and diverse environmental substances; however, the adverse effects of environmental exposure on the general population are largely unknown. This review summarizes the conclusions of the comprehensive epidemic literature and representative case reports relevant to emerging contaminants and the human body to address concerns about potential harmful health effects in the general population. The most prevalent emerging contaminants include perfluorinated compounds, water disinfection byproducts, gasoline additives, manufactured nanomaterials, human and veterinary pharmaceuticals, and UV-filters. Rare but statistically meaningful connections have been reported for a number of contaminants and cancer and reproductive risks. Because of contradictions in the outcomes of some investigations and the limited number of articles, no significant conclusions regarding the relationship between adverse effects on humans and extents of exposure can be drawn at this time. Here, we report that the current evidence is not conclusive and comprehensive and suggest prospective cohort studies in the future to evaluate the associations between human health outcomes and emerging environmental contaminants.

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Adverse Reactions to Sunscreen Agents

Cited by 81 publications

References 145 publications

Anti-aging and Sunscreens: Paradigm Shift in Cosmetics

Anti-aging and Sunscreens: Paradigm Shift in Cosmetics

Radioprotectors.org: an open database of known and predicted radioprotectors

Overview of Emerging Contaminants and Associated Human Health Effects

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