Adverse reactions to human papillomavirus vaccine in the Valencian Community (2007–2011)

Adverse events following school-based vaccination of girls with quadrivalent human papillomavirus vaccine in Slovenia, 2009 to 2013

“…Reporting rate of seizures accompanying syncope after vaccination with qHPV in Slovenia was similar to the rates reported from Spain and Australia (3.4 vs 3.2 and 2.6 per 100,000 qHPV doses distributed, respectively) [22,25]. However, monitoring of qHPV occurred between 2006 and 2009, during which a total of 600,558 doses were administered in the Vaccine Safety Database (VSD) population, and no association between qHPV and seizures, whether recurrent or new onset was observed [14].…”

“…However, monitoring of qHPV occurred between 2006 and 2009, during which a total of 600,558 doses were administered in the Vaccine Safety Database (VSD) population, and no association between qHPV and seizures, whether recurrent or new onset was observed [14]. A relatively higher reporting rate of headache was reported in Slovenia in comparison to the US and Spain (40.3 per 100,000 qHPV doses distributed vs 4.1 and 23.5, respectively), and relatively higher reporting rate of fever in comparison to the US (35.3 vs 0.4 per 100,000 qHPV doses distributed) [20,22,27]. In contrast, although local reactions are usually frequently reported AEFIs with qHPV that are generally of short duration and resolve spontaneously, in our analyses only one fifth of reports with AEFIs with qHPV involved local reactions, mainly pain and swelling [28].…”

“…Syncope, which may be considered a procedure-or anxiety-related AEFI, was reported at similar reporting rates of ca 8-10 per 100,000 vaccine doses distributed as reported from the US, and Australia, but at a somewhat lower rate in comparison to the reporting rate from Spain (13.4 vs 17 per 100,000 qHPV doses distributed) [22][23][24][25][26].…”

Small fiber neuropathy in unexpected clinical settings: a review

“…Human papillomavirus (HPV) vaccination is reported with more adverse reactions than other vaccines (73). Common neurologic complications after HPV vaccination have been complex regional pain syndrome, postural orthostatic tachycardia syndrome (POTS), and FM, all reported with concurrent small fiber neuropathy.…”

Trends of Adverse Events Following Immunization (AEFI) Reports of Human Papillomavirus Vaccine in the Valencian Community—Spain (2008–2018)

“…Those cases were extensively covered by all media at the regional and national levels [22]. Subsequently, in 2013, a study described the suspected adverse reactions following the HPV vaccine during the first four years of HPV vaccination [23].…”