Adverse reactions to drugs: in vitro studies with isolated cells

Ennis, Madeleine; Nehring, E.; Schneider, C

doi:10.1007/s00011-004-0358-1

Cited by 4 publications

(3 citation statements)

References 17 publications

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“…Various methods should be studied to distinguish pseudo-allergic reactions from true IgE mediated type I allergy. For example, the mast cell line, as an in vitro model, is extensively used to detect the release of histamine induced by drugs (99). Among which, rat peritoneal mast cells have been the most popular model for many years (100).…”

Section: Nonclinical Detection Methodsmentioning

confidence: 99%

Agents that induce pseudo-allergic reaction

Wang

Hs²,

Zp³

2011

Drug Discov Ther

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Pseudo-allergic reactions may result from the activation of inflammatory or anaphylactic mechanisms independent of antigen-specific immune responses. Recent statistics show that pseudo-allergic reactions may represent as high as two thirds of all immediate hypersensitivity reactions, implying a great amount of morbidity and numerous health care costs. In this review, we concentrate on agents mediating pseudo-allergic reactions and evaluate accurately the available information on their modes of action. The agents discussed here are divided into three types: (i) Direct mast cell activators, which may activate mast cells in an IgE-independent manner, such as opioid drugs, basic secretagogues and calcium ionophore A23187; (ii) Complement activators, including liposomes, radiocontrast media and Cremophor EL, which may activate the complement system by different pathways: the classical pathway, the mannose-binding lectin pathway or the alternative pathway; (iii) Nonsteroidal anti-inflammatory drugs, which may inhibit the function of cyclooxygenase-1, resulting in the occurrence of adverse reactions. In addition, nonclinical detection methods of pseudoallergic reactions are also reviewed in order to supply valuable information for clinical diagnosis.

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Section: Nonclinical Detection Methodsmentioning

confidence: 99%

Agents that induce pseudo-allergic reaction

Wang

Hs²,

Zp³

2011

Drug Discov Ther

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“…This is illustrated by an experiment in which isolated peritoneal and lung mast cells were exposed to different ICM from normotensive and hypertensive rats. Mast cells derived from hypertensive rats released significantly more histamine than those from normotensive rats [65]. Stellato et al [64] showed heterogeneous histamine and tryptase release from human basophils and human mast cells isolated from lung, skin, and heart tissue after exposure to ICM.…”

Section: Heterogeneity Of Mediator Release In Cell Populationsmentioning

confidence: 97%

“…For example, Ennis et al [65] showed that cardiac mast cells were more sensitive to ICM than were mast cells from lungs, livers, and kidneys. Moreover, histamine release depends not only on the tissue origin of mast cells, but also on underlying mechanisms related to diseases.…”

Section: Heterogeneity Of Mediator Release In Cell Populationsmentioning

confidence: 98%

Hypersensitivity Reactions to Iodinated Contrast Media

Guéant-Rodríguez¹,

Romano²,

Barbaud³

et al. 2006

CPD

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Adverse reactions after iodinate contrast media (ICM) administration have been observed, which can be classified as immediate (i.e., occurring within one hour after administration) and delayed or non-immediate (i.e., occurring more than one hour after administration). Even though the incidence of ICM adverse reactions has been significantly reduced by the introduction of non-ionic compounds, immediate reactions still occur in about 3% of administrations. Different pathogenic mechanisms have been suggested for ICM reactions, including immunologic ones. Basophils and mast cells participate in immediate reactions through the release of mediators like histamine and tryptase, whereas a T-cell-mediated pathogenic mechanism is involved in most non-immediate reactions, particularly maculopapular rashes. Skin tests and specific IgE assays are carried out to diagnose immediate hypersensitivity reactions, while both delayed-reading intradermal tests and patch tests are usually performed to evaluate non-immediate reactions. However, in vitro specific IgE assays are not commercially available. As far as in vitro tests are concerned, a response involving ICM-related T-cell activity may be assessed by the lymphocyte transformation test. Allergologic evaluation appears to be indicated in hypersensitivity reactions to ICM, although the sensitivity, specificity, and predictive values of allergologic tests have not yet been established. This paper summarizes the current state of the art and addresses the research that is still needed on the pathogenic mechanisms, diagnosis, and prevention of ICM-induced hypersensitivity reactions.

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