Influence of Magnetic Resonance Contrast Media on the Activity of Histamine Inactivating Enzymes

Kuefner, Michael A.; Feurle, Johannes; Uder, Michael; Bautz, W.; Schwelberger, H. G.

doi:10.1016/j.acra.2008.09.005

Cited by 3 publications

(5 citation statements)

References 29 publications

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“…40 At higher dosages (50-150 mM), Gd 3+ -chelate complexes have been shown to release histamine in vitro. 40 Relaxivity is an important measure of efficacy for T 1 MRI CAs.…”

Section: +mentioning

confidence: 99%

“…40 At higher dosages (50-150 mM), Gd 3+ -chelate complexes have been shown to release histamine in vitro. 40 Relaxivity is an important measure of efficacy for T 1 MRI CAs. 1 Our previous results show that the r 2 /r 1 ratio for water-solubilized GNP solutions is 2.2, which is in the range reported for Mn 2+ -or Gd 3+ -chelate complexes (r 2 /r 1 ∼1.0-2.5) T 1 MRI CAs.…”

Section: +mentioning

confidence: 99%

“…These results are encouraging since histamine can also stimulate fibroblast proliferation and collagen production, and can play an important role in skin fibrosis -a major symptom associated with nephrogenic systemic fibrosis. 40 Studies on Gd 3+ -and Mn…”

Section: Nm Sectionmentioning

confidence: 99%

“…[38][39][40] Histamine, a naturally occurring biomolecule found in vivo, is released as a response to allergic reactions 40 and is considered a good marker to evaluate the propensity of an MRI CA to elicit an allergic response. Our results show no significant release of histamine at GNP-Dex concentrations of 0.1, 1.0, and 10.0 mg/mL compared with the control (Table S3).…”

Section: Nm Sectionmentioning

confidence: 99%

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Physicochemical characterization of a novel graphene-based magnetic resonance imaging contrast agent

Kanakia¹,

Toussaint²,

Chowdhury³

et al. 2013

IJN

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Abstract:We report the synthesis and characterization of a novel carbon nanostructure-based magnetic resonance imaging contrast agent (MRI CA); graphene nanoplatelets intercalated with manganese (Mn 2+ ) ions, functionalized with dextran (GNP-Dex); and the in vitro assessment of its essential preclinical physicochemical properties: osmolality, viscosity, partition coefficient, protein binding, thermostability, histamine release, and relaxivity. The results indicate that, at concentrations between 0.1 and 100.0 mg/mL, the GNP-Dex formulations are hydrophilic, highly soluble, and stable in deionized water, as well as iso-osmolar (upon addition of mannitol) and isoviscous to blood. At potential steady-state equilibrium concentrations in blood (0.1-10.0 mg/mL), the thermostability, protein-binding, and histamine-release studies indicate that the GNP-Dex formulations are thermally stable (with no Mn 2+ ion dissociation), do not allow non-specific protein adsorption, and elicit negligible allergic response. The r 1 relaxivity of GNP-Dex was 92 mM

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“…40 At higher dosages (50-150 mM), Gd 3+ -chelate complexes have been shown to release histamine in vitro. 40 Relaxivity is an important measure of efficacy for T 1 MRI CAs.…”

Section: +mentioning

confidence: 99%

Section: +mentioning

confidence: 99%

Section: Nm Sectionmentioning

confidence: 99%

Section: Nm Sectionmentioning

confidence: 99%

See 2 more Smart Citations

Physicochemical characterization of a novel graphene-based magnetic resonance imaging contrast agent

Kanakia¹,

Toussaint²,

Chowdhury³

et al. 2013

IJN

View full text Add to dashboard Cite

show abstract

“…The Food and Drug Administration (FDA) of the USA has suggested that gadolinium (Gd)-containing MRI contrast agents may be associated with the development of nephrogenic systemic fibrosis (NSF) and nephrogenic fibrosing dermopathy in patients with kidney failure. 3 The FDA has also stated that caution should be exercised in W Zhang, X-X Ma, Y-M Ji et al…”

Section: Introductionmentioning

confidence: 99%

Haemorrhage Detection in Brain Metastases of Lung Cancer Patients using Magnetic Resonance Imaging

Zhang

et al. 2009

J Int Med Res

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Magnetic resonance susceptibility-weighted imaging (SWI) is a new, highly-sensitive technique used to detect haemorrhage. This study evaluated the ability of magnetic resonance imaging (MRI) to detect haemorrhage in 45 lung cancer patients with brain metastases and compared the results with T2*weighted imaging (T2*WI) and contrast-enhanced T1-weighted imaging (CE-T1WI). Eighty-nine haemorrhagic brain metastases were identified in 31 patients using SWI, 68 were identified in 23 patients using T2*WI and 46 were identified in 14 patients using CE-T1WI. Most micro-bleeds could only be identified by SWI. It was concluded that haemorrhage is a frequent occurrence in brain metastases originating from lung cancer and that haemorrhage can be detected using SWI in a majority of brain metastases patients.

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Estimates of Risk, Empirical Treatment Observations, and Unexpected Laboratory Findings Reveal the Complexity of Nephrogenic Systemic Fibrosis

High¹

2009

Arch Dermatol

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Influence of Magnetic Resonance Contrast Media on the Activity of Histamine Inactivating Enzymes

Cited by 3 publications

References 29 publications

Physicochemical characterization of a novel graphene-based magnetic resonance imaging contrast agent

Physicochemical characterization of a novel graphene-based magnetic resonance imaging contrast agent

Haemorrhage Detection in Brain Metastases of Lung Cancer Patients using Magnetic Resonance Imaging

Estimates of Risk, Empirical Treatment Observations, and Unexpected Laboratory Findings Reveal the Complexity of Nephrogenic Systemic Fibrosis

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