Adverse Reaction in Patients with Drug Allergy History After Simultaneous Intravenous Fundus Fluorescein Angiography and Indocyanine Green Angiography

Su, Zhaoan; Ye, Panpan; Tang, Yan; Zhang, Lixia; Shu, Xiaohong

doi:10.1089/jop.2011.0221

Cited by 42 publications

(39 citation statements)

References 18 publications

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“…Furthermore, anaphylactic reaction to the ICG has been reported in the literature, and it is contraindicated in patients with iodine allergy. 144 In recent times, ICG-FA has been used more frequently for intraoperative assessment of microvascular circulation in free flap operations. 145,146 Fluorometry is one of the few techniques in the current literature to provide CEBM level 2 evidence for an adjunctive monitoring technique.…”

Section: Fluorometrymentioning

confidence: 99%

Current Evidence for Postoperative Monitoring of Microvascular Free Flaps

Chae

Rozen

Whitaker

et al. 2015

Annals of Plastic Surgery

115

133

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Section: Fluorometrymentioning

confidence: 99%

Current Evidence for Postoperative Monitoring of Microvascular Free Flaps

Chae

Rozen

Whitaker

et al. 2015

Annals of Plastic Surgery

115

133

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“…By calculating the decorrelation of the signal amplitude from repeated consecutive B-scans in the same section, a contrast is generated between static and nonstatic tissue, resulting in a vascular decorrelation signal that enables visualization of 3-dimensional retinal and choroidal vasculature [8]. OCT-A does not require administration of an intravenous dye such as fluorescein or indocyanine green, thus avoiding potential risks which can result in nausea or other more serious adverse events [9,10]. …”

Section: Introductionmentioning

confidence: 99%

Optical Coherence Tomography Angiography during Follow-Up: Qualitative and Quantitative Analysis of Mixed Type I and II Choroidal Neovascularization after Vascular Endothelial Growth Factor Trap Therapy

et al. 2015

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Purpose: To report the optical coherence tomography angiography (OCT-A) findings in an exudative age-related macular degeneration (AMD) patient presenting mixed type I and II choroidal neovascularization (CNV) during follow-up after intravitreal vascular endothelial growth factor (VEGF) trap treatment. Methods: The clinical assessment included both traditional multimodal imaging, based on fluorescein angiography (FA), indocyanine green angiography (ICGA) and B-scan OCT, and OCT-A at baseline and follow-up. OCT-A images were obtained using a Spectralis OCT-A prototype able to acquire 70,000 A-scans per second, with a resolution of 7 µm axially and 14 µm laterally. An amplitude decorrelation algorithm developed by Heidelberg Engineering was applied to a volume scan, on a 15 × 5° area, which was composed of 131 B-scans (35 frames per scan) at a distance of 11 µm each. The borders of type I and type II CNV were manually outlined and then the areas were analyzed using the provided automated software before and after treatment. Results: The qualitative approach revealed a substantial decrease in the visibility of tiny branching vessels and anastomoses both in type I and type II components of the neovascular complex, associated with persistence of a clear hyperintense signal coming from the larger trunks, which remained well-perfused. Quantitative analysis confirmed a reduction of the lesion area after VEGF trap treatment: the type II component decreased from 0.25 to 0.19 mm², while the type I component decreased from 2.03 to 1.80 mm². Conclusions: Our study qualitatively and quantitatively demonstrated the response of a mixed type I-II CNV to intravitreal VEGF trap therapy. Although FA remains the gold standard for determining the presence of leakage and OCT easily shows fluid accumulation and its variations, OCT-A offers noninvasive monitoring of the retinal and choriocapillaris microvasculature in patients with CNV, aiding in diagnosis and treatment decisions during follow-up.

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“…Both FA and ICGA are invasive imaging techniques that require intravenous injection of a dye - fluorescein or indocyanine green, respectively. Although generally safe, side effects like nausea, vomiting or even severe allergic reactions may develop in a minority of patients, thus limiting its repeated use [5,6]. The advent of OCT revolutionized retinal imaging by providing a fast, simple and noninvasive method to assess retinal structure at a microscopic level [7,8].…”

Section: Introductionmentioning

confidence: 99%

Sequential Morphological Changes in the CNV Net after Intravitreal Anti-VEGF Evaluated with OCT Angiography

et al. 2016

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Purpose: To assess and describe sequential morphological changes in the choroidal neovascularization (CNV) net using optical coherence tomography angiography (OCTA) in patients undergoing treatment with intravitreal antivascular endothelial growth factor (VEGF). Methods: Prospective cohort study. OCTA was performed sequentially: before (t0), 1 h (t1), 1 week (t2) and 1 month after the injection (t3), using Avanti RTVue XR equipped with the AngioVue® software (Optovue, Calif., USA). All images were classified by two independent graders. Results: Ten eyes of 10 patients, with a mean age of 72.4 ± 10.5 years, were included. CNV morphology was described as tree-like in 5 eyes, glomerular in 1 and fragmented in 4. A fibrovascular capsule surrounding the CNV net was found in 4 eyes and a feeder trunk was noticed in 6. No changes were observed at t1. Loss of peripheral capillaries, vessel fragmentation and decreased vessel density were evident in 8 eyes at t2. The CNV capillary density and the peripheral anastomosis increased in all of these at t3. Two eyes remained unchanged through the whole length of follow-up. Conclusions: Significant changes in the CNV net can be observable in OCTA at least 1 week after intravitreal anti-VEGF. The safety of frequent examinations may provide a method of gauging treatment effects.

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Adverse Reaction in Patients with Drug Allergy History After Simultaneous Intravenous Fundus Fluorescein Angiography and Indocyanine Green Angiography

Abstract: Simultaneous IFVA and ICGA are generally safe procedures with an acceptable incidence of an adverse reaction. However, patients with drug allergy history may have a higher incidence and greater severity of an adverse reaction.

Cited by 42 publications

References 18 publications

Current Evidence for Postoperative Monitoring of Microvascular Free Flaps

Current Evidence for Postoperative Monitoring of Microvascular Free Flaps

Optical Coherence Tomography Angiography during Follow-Up: Qualitative and Quantitative Analysis of Mixed Type I and II Choroidal Neovascularization after Vascular Endothelial Growth Factor Trap Therapy

Sequential Morphological Changes in the CNV Net after Intravitreal Anti-VEGF Evaluated with OCT Angiography

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