Adverse events and antibody response to accelerated immunisation in term and preterm infants.

Abstract

A study was performed to compare adverse events and antibody response in term and preterm children vaccinated with diphtheria, tetanus, and pertussis vaccine at 2, 3, and 4 months of age. A total of 124 children were recruited and grouped according to gestational age: 37 weeks or more (n= 52), 34 to 36 weeks (n=40), and less than 34 weeks (n=32). Study nurses followed up children 24 hours after each vaccination to record temperature, redness, and swelling at the injection site and any systemic symptoms. Proportions of children experiencing adverse events did not differ between groups. Blood samples were obtained six weeks after the vaccination course at which time all children had protective levels of diphtheria and tetanus antitoxins. Geometric mean antibody titres (95% confidence interval) to pertussis toxin were 2754 (2042 to 3715), 5495 (4074 to 7413), and 3690 (2951 to 4677), to filamentous haemagglutinin were 541 (282 to 1023), 951 (537 to 1698), and 614 (426 to 1023), and to agglutinogens 2 and 3 were 12106 (6918 to 21380), 21330 (13183 to 34674), and 22387 (15136 to 33113) in children born at a gestational age of less than 34 weeks, 34 to 36 weeks, and 37 weeks or more respectively. These findings support the current recommendations that preterm children are vaccinated at chronological age according to the national schedule. (Arch Dis Child 1995; 72: 230-232)

Apnoea and bradycardia in preterm infants following immunisation with pentavalent or hexavalent vaccines

“…Studies reporting no increased risk of apnoea in preterm infants after the first DTPw vaccination were based on parents' diaries in outpatient settings [1,7]. In such settings without monitoring, however, it may be difficult to recognise apnoea.…”

Adverse cardiorespiratory events following primary vaccination of very low birth weight infants

“…Estudos prévios da vacina de células inteiras contra coqueluche relataram sobre eventos cardiorrespiratórios (ou seja, recorrência de apneia, bradicardia ou dessaturações de SpO 2 ) em recém-nascidos pré-termo [2][3][4][5][6] . Em estudos publicados recentemente, foi usada uma vacina acelular contra coqueluche, mas também foram relatadas reações adversas semelhantes [7][8][9][10][11][12] .…”

Impfungen von Frühgeborenen

“…Es ist gut belegt, dass die üblichen lokalen und systemischen Reaktionen bei Frühgeborenen nicht häufiger auftreten als bei reifen Neugeborenen [2,17]. Frühgeborene, die vor der vollendeten 28.…”