2006
DOI: 10.1016/j.jaad.2005.01.010
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Adverse effects of topical glucocorticosteroids

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Cited by 893 publications
(685 citation statements)
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“…Specifically, long‐term, uninterrupted use of glucocorticoids can cause striae, increase the risk of adrenal suppression, and slow linear growth 12, 13. Calcineurin inhibitors are associated with the potential risk of malignancy (skin cancer, lymphoma), although a direct causal relationship has not been established 2.…”
Section: Discussionmentioning
confidence: 99%
“…Specifically, long‐term, uninterrupted use of glucocorticoids can cause striae, increase the risk of adrenal suppression, and slow linear growth 12, 13. Calcineurin inhibitors are associated with the potential risk of malignancy (skin cancer, lymphoma), although a direct causal relationship has not been established 2.…”
Section: Discussionmentioning
confidence: 99%
“…The anti-inflammatory effect of hydrocortisone is due to reduction of histamine release, reduction of IgG production and decreasing of the activity of neutrophils and macrophages [4][5][6] . Clotrimazole; 1-(o-chloro-α,α-diphenylbenzyl)imidazole is an imidazole derivative with antimycotic activity that is known to inhibit cytochrome P-450, ergosterol biosynthesis, and proliferation of cells and to interfere with cellular Ca 2+ homeostasis 7-9 .…”
Section: Introductionmentioning
confidence: 99%
“…Hydrocortisone (cortisol);11,17,20-dione, the main physiologic glucocorticoid in humans has an anti-inflammatory and an immunosuppressive effect besides its role on carbohydrate and protein metabolism 1-3 . The anti-inflammatory effect of hydrocortisone is due to reduction of histamine release, reduction of IgG production and decreasing of the activity of neutrophils and macrophages [4][5][6]imidazole is an imidazole derivative with antimycotic activity that is known to inhibit cytochrome P-450, ergosterol biosynthesis, and proliferation of cells and to interfere with cellular Ca 2+ homeostasis 7-9 . …”
mentioning
confidence: 99%
“…Within the last several decades, there has been enough evidence to support the concept that AD has an immunologic basis (Leund 1997) and is associated with an increase in IgE levels (Stephen et al 1973). Although the majority of AD patient are still being treated with topical corticosteroids as the first line of treatment, there is still an pressing requirement for other anti-inflammatory drugs that can be used as an alternative to, or as an intermittent or alternating therapy during longterm treatment with topical corticosteroids because of the concern regarding long-term side effects of corticosteroid therapy (Charman et al 2000;Henge et al 2006).…”
Section: Discussionmentioning
confidence: 99%
“…However, antihistamines are associated with various side effects, the most serious of which is their sedative potential (Kay 2000). Topical corticosteroids, on the other hand, are associated with side effects such as atrophy, rosacea, acne, purpura, hyperglycaemia, glaucoma, perioral dermatitis and purpura (Arellano et al 2007;Henge et al 2006). Systemic application of corticosteroids is effective in relieving the symptoms of AD but can only be administered once or twice annually because of long-term side effects such as osteopenia and cataracts (Sidbury and Hanifin 2000).…”
Section: Introductionmentioning
confidence: 99%