A comparison of the leaf gel extracts of Aloe ferox and Aloe vera in the topical treatment of atopic dermatitis in Balb/c mice

Abstract

Aloe vera gel is widely used in the treatment of an array of disturbances, especially skin disorders. The woundhealing effects have been attributed to its moisturiz-ing and anti-inflammatory effects as well as its beneficial effect on the maturation of collagen. The aim of the present study is to compare the effects of topically applied extracts of Aloe ferox with that of Aloe vera on the symptoms as well as IgE levels of a mouse model of atopic dermatitis (AD). Mice were sensitized and challenged with 2,4-dinitrochlorobenzene and treated afterwards for 10 consecutive days with the gels of either A. ferox or A. vera applied topically to the affected areas. A placebo gel was used for the control mice. Blood was collected at the beginning and end of the treatment period to measure serum IgE levels. Although the gels of both the Aloe species inhibited the cutaneous inflammatory response as well as serum IgE levels in the rats, the extracts of A. ferox were superior to that of A. vera in reducing IgE levels. The gels of A. ferox and A. vera, applied topically, may be a safe and useful alter-native to antihistamines and topical corticosteroids, for the treatment of patients suffering from recurring chronic AD.

Oral treatment with Aloe polysaccharide ameliorates ovalbumin‐induced atopic dermatitis by restoring tight junctions in skin

“…AD is an allergic skin disease. Two key studies have used animal models to study A. vera in AD ; however, these studies obtained contrasting results. One study that applied A vera gel topically in 2,4 dinitrofluorobenzene‐induced AD mice for 10 days reported significant reduction in serum IgE levels and decreased epidermis thickness compared to in the control animals .…”

“…Two key studies have used animal models to study A. vera in AD ; however, these studies obtained contrasting results. One study that applied A vera gel topically in 2,4 dinitrofluorobenzene‐induced AD mice for 10 days reported significant reduction in serum IgE levels and decreased epidermis thickness compared to in the control animals . However, a study that evaluated the effects of oral administration of A vera gel extracts on spontaneous AD‐like NC/Nga mice showed that six weeks of treatment with 0.8 mg/kg A vera gel extracts resulted in decreased serum IL‐5 and IL‐10 concentrations, but increased IgE levels compared with those in the control group .…”

“…Notably, A vera polysaccharides have been shown to modulate immunity in both humans and mice . Topical application of A vera extract helped treat the AD . It is not only used topically, but also has been administered orally via liquid formulations, tablets and capsules .…”

“…13,20 Topical application of A vera extract helped treat the AD. 21,22 It is not only used topically, but also has been administered orally via liquid formulations, tablets and capsules. 13,14 However, the effects of orally administered Aloe polysaccharides in AD-related diseases have not been fully elucidated.…”

Desenvolvimento e eficácia anti-inflamatória não-clínica de uma formulação anti-acne

“…O efeito antiinflamatório pode estar relacionado ao bloqueio da síntese de prostaglandinas e tromboxano, além de ação antioxidante da vitamina E presente na planta [29]. Recentemente, foi sugerido que o gel de Aloe vera pode ser uma alternativa segura eficaz aos anti-histamínicos e corticoesteróides para o tratamento da dermatite atópica crônica [30].…”