Adverse Effects of Chemotherapy with Doxorubicin and Vincristine in Canine Transmissible Venereal Tumour

Yadav, Anup; Kumar, Praveen; kesh, Lo; wani, Ash; Kumar, Pankaj; Yadav, Rajendra; Bugalia, N. S.; Diwakar, Ramaswamy

doi:10.20546/ijcmas.2018.712.283

Cited by 3 publications

(4 citation statements)

References 5 publications

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“…Similar findings were reported by Albanese et al, (2006). No significant difference in these variables between and within the treatment groups (p>0.05) indicated that the hepatic and renal parenchyma was not significantly damaged (Yadav et al, 2018). The normal ALT levels (Braz and Marinho, 2021) indicated no significant injury to the hepatic parenchyma caused by cytotoxic drug metabolites.…”

Section: Resultssupporting

confidence: 79%

Haemato-biochemical evaluation of chemotherapy in canine transmissible venereal tumour

Nazer,

Becha,

Jayakumar

et al. 2023

ijar

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The study was aimed at haematological and biochemical evaluation of chemotherapeutic response in canine transmissible venereal tumour (CTVT). Thirty-one CTVT confirmed dogs presented to University Veterinary Hospitals were categorised into three groups. The group I (n=13) dogs were treated with vincristine sulphate, while group II (n=9) and III (n=9) dogs were treated with vincristine along with ivermectin and cyclophosphamide respectively. Haemato-biochemical evaluations were performed on the day of presentation and at weekly intervals till complete tumour regression. The haemato-biochemical parameters like TEC, Hb, VPRC, TP, BUN, creatinine, albumin, globulin and ALT were within normal range. Significant differenceswere observed in DLC, TC, MCV, AST, ALP and bilirubin levels (p<0.05) during treatment. Various blood dyscrasias like leucocytosis was observed in group I and group II, and thrombocytopenia in group III. Highly elevated AST, ALP and bilirubin were observed in all three groups. But combination therapy with ivermectin was more efficient with fewer adverse effects and decreased treatment duration.

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Section: Resultssupporting

confidence: 79%

Haemato-biochemical evaluation of chemotherapy in canine transmissible venereal tumour

Nazer,

Becha,

Jayakumar

et al. 2023

ijar

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“…There was non-significant decrease in TEC in group B and C, which could be due to chemotherapy induced erythrocytopenia due to myelosuppression. Yadav et al (2017) reported consistent decreasing (P>0.05) trend of TEC in dog affected with TVT which was treated with vincristine and doxorubicin during post-operative period. There was significant (P<0.05) decrease in TLC in group B and C, as these cytotoxic drugs suppress the replicating precursor cells of bone marrow, thus, resulting in reduced production of leucocytes.…”

Section: Haematological Parametersmentioning

confidence: 55%

“…However, the TSP levels in group A and C showed marginal changes during period of observation. Yadav et al (2017) reported that serum total proteins showed slight drop on day 7 followed by rise (P>0.05) on day 14 and elevated profiles continued during post vincristine and doxorubicin therapy in TVT affected dogs. In group B, serum urea nitrogen and serum creatinine levels showed significant (P<0.05) increase upto 30 th day which furthers significantly (P<0.05) decrease at 60 th day whereas, in group A and C, non-significant variation was observed upto 60 th day of observation period.…”

Section: Response To Treatment In Different Groupsmentioning

confidence: 94%

Treatment of Canine Transmissible Venereal Tumour using Different Surgico-chemotherapeutic Protocols

Punchkande¹,

Dewangan²,

Sharda³

et al. 2021

IJAR

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Background: Canine transmissible venereal tumour (CTVT) also known as infectious sarcoma, venereal granuloma, transmissible lymphosarcoma or sticker tumour is usually transmitted through coitus and mainly affects the external genitalia of young sexually matured dogs. Surgery, chemotherapy, radiotherapy and immunotherapy are considered as effective treatment protocols. Therefore, depending upon the availability present study was designed to investigate the efficacy of different surgico-chemotherapeutic protocols for treatment of canine transmissible venereal tumour.Methods: The study was conducted during January 2018 to July 2018 at the Teaching Veterinary Clinical Complex (TVCC) and Department of Veterinary Surgery and Radiology, College of Veterinary Science and A.H., Anjora, Durg (C.G.) on 18 canines of various breed, irrespective of age, sex and divided into three groups consisting 6 animals in each group. Group A was treated with surgical excision of tumour only where as Group B and Group C were treated with surgical excision of tumour followed by administration of Doxorubicin (30mg/m2) BSA and Vincristine sulphate (0.025 mg/kg) intravenously alongwith DNS at 7th and 14th post-operative days respectively. Different physiological and haemato-biochemical parameters (Hb, PCV, TLC, TPC, DLC, serum glucose, TSP, SUN, SC, ALT, AST and ALP) were recorded preoperatively, postoperatively and after chemotherapy at 10th, 30th and 60th days intervals.Result: The present investigation showed transient changes in physiological and haemato-biochemical parameters before, post surgery and post chemotherapeutic management and was within normal range. Histopathological examination revealed confluent sheet of tumour cells arranged in large round oval or polyhedral shaped distributed in tight clusters or cords. Group A showed mild to moderated reoccurrence while Group B showed minimum reoccurrence. Group C showed no reoccurrence. Thus, surgery combined with vincristine therapy is most effective for treating dogs suffering with transmissible venereal tumour.

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“…In addition to the total erythrocyte count in dogs affected by TVT, the RDW tends to remain within the reference values without showing an increase in cell diameter, characteristic of young cells due to spinal cord regeneration. Even during the post-treatment period, chemotherapeutic agents may act by suppressing erythropoiesis in the BM (Jumean et al 1979, Yadav et al 2018.…”

Section: Discussionmentioning

confidence: 99%

Comparison between hematological and biochemical changes caused by conventional and metronomic chemotherapies in the treatment of canine transmissible venereal tumor

Braz

Marinho

2021

Pesq. Vet. Bras.

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This study aimed to report the hematological and biochemical changes caused by conventional and metronomic chemotherapies, using vincristine sulfate to treat canine Transmissible Venereal Tumor (TVT). Twelve dogs were selected, six of them for the group receiving conventional chemotherapy (G1), and six dogs for the group receiving metronomic chemotherapy (G2). The G1 group received vincristine sulfate once a week at the dose of 0.75mg/m² until the tumor had disappeared with treatment, and the G2 group was treated with vincristine sulfate three times a week at the dose of 0.25mg/m2 until the tumor had disappeared. Before and after chemotherapy treatment, hematological and biochemical blood tests were performed to evaluate the main alterations caused by both chemotherapeutic models. Dogs undergoing conventional chemotherapy had significant leukocyte changes (p<0.05), causing neutropenia and leukopenia. In dogs undergoing metronomic chemotherapy, leukocytes remained within the reference range. Half of the dogs in group G1 had normochromic, normocytic anemia. The only biochemical alteration observed was the increase of urea in group G2. Thus, metronomic chemotherapy for the treatment of TVT with vincristine sulfate proved to be an excellent method for treatment, with fewer adverse effects, especially in maintaining the leukogram of dogs within normal range and reducing the number of anemia in animals during treatment.

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Adverse Effects of Chemotherapy with Doxorubicin and Vincristine in Canine Transmissible Venereal Tumour

Cited by 3 publications

References 5 publications

Haemato-biochemical evaluation of chemotherapy in canine transmissible venereal tumour

Haemato-biochemical evaluation of chemotherapy in canine transmissible venereal tumour

Treatment of Canine Transmissible Venereal Tumour using Different Surgico-chemotherapeutic Protocols

Comparison between hematological and biochemical changes caused by conventional and metronomic chemotherapies in the treatment of canine transmissible venereal tumor

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