Adverse effects of bisphenol A on the testicular parenchyma of zebrafish revealed using histomorphological methods

Lora, Antonio; Molina, A.; Bellido, C.; Blanco, Alfonso; Monterde, J. G.; Moyano, M.R.

doi:10.17221/212/2015-vetmed

Cited by 19 publications

(8 citation statements)

References 30 publications

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“…We have also seen how BPa triggers important effects on ovaries and testicles, which could interfere with fertility (MOLINa et al, 2013;LOra et al, 2016), in addition to modifying other systems, such as the musculoskeletal system (gIMéNez et al, 2016).…”

Section: Resultsmentioning

confidence: 99%

Histopathological study of the Achilles tendon after exposure to bisphenol-A and its subsequent treatment with platelet growth factors

Bellido¹,

Córdoba²,

Abellán³

et al. 2018

Vet. arhiv

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Bisphenol-a is a well-known compound with estrogenic activity, which is produced in tons world-wide and is abundantly used as a component of food containers, so that it frequently migrates into food and appears as an environmental pollutant. this study aimed to assess the effects of Bisphenol-a at the tendon level, possible reversal after it is withdrawn from exposure, and its recovery after the application of plate-enriched plasma. For this purpose, 16 animals were randomly distributed to one of the experiment groups: control group, group treated with BPa (for 4 months), group BPa-withdrawal (treated for 2 months with BPa and two months without BPa), and platelet-rich plasma (PrP) group (treated for 2 months with BPa, when it was withdrawn and the PrP treatment began for 2 months). at the end of the treatments biopsy of the achilles tendon was carried out. the samples were analysed by optical and electron microscopy and immunohistochemistry. histopathology was a fundamental tool in the evaluation of the tendon after exposure to Bisphenol-a. Our results showed how, after withdrawal of BPa, there was recovery from the lesions caused, with diminution in the type III collagen fibres along with tendon vascularization processes; in the group to which PRP was applied, almost complete recovery from the lesions caused occurred, and the immunocytochemistry test was negative for the type III collagen fibres. Our results indicate that tendons were affected after BPA exposure, but that the lesions were partially reversible after BPa was withdrawn. PrP application enabled tendon lesions to recuperate and all signs of inflammation disappeared.

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Section: Resultsmentioning

confidence: 99%

Histopathological study of the Achilles tendon after exposure to bisphenol-A and its subsequent treatment with platelet growth factors

Bellido¹,

Córdoba²,

Abellán³

et al. 2018

Vet. arhiv

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“…Additionally, exposure to BPA at 16 μg/L in fathead minnows revealed a decrease in the number of mature spermatozoa (Sohoni et al, 2001). No significant changes in the percentages of cellular population were observed following exposure to lower concentrations of BPA (1 and 10 μg/L); however, increasing the exposure dose can decrease the numbers of mature spermatozoa (Lora et al, 2016).…”

Section: Xenos Teroids Effec Ts On Gonadal His Topathologymentioning

confidence: 87%

Xenosteroids in aquaculture with special consideration to Lake Manzala (Northern delta lake, Egypt): Types, sources and mechanism of action

et al. 2021

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Egyptian aquaculture production has dramatically increased in recent years and is anticipated to represent a yield of 1.8MMT in 2018. Increased demand for fish production has led to a higher intensification of aquaculture to face these challenges.However, the current aquaculture practices and restricted governmental legislation can prompt raised concerns about aquaculture pollution. The current review summarizes our knowledge concerning general Egyptian aquaculture, legislation and practices that can lead to persistent pollutant exposure in farmed finfish. Xenosteroids are critical pollutants influencing fish health, as detailed in this review, and are considered significant health hazards not only to cultured fish but also to human wellbeing, raising a public health concern. Additional research studies are warranted to better understand their public health concerns and develop strategic plans and policies to prevent these impacts and maintain fish welfare and aquaculture sustainability.

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“…Additionally, BPA exposure at level 16 μg/L in fathead minnows elicited a decrease in the number of mature spermatozoa [ 68 ]. Lower concentrations of BPA (1 and 10 μg/L) did not significantly affect the cell population percentages; however, increasing the exposure dose can decrease the numbers of mature shapes [ 98 ]. These observations reported suggesting that BPA causes modulations in sperm maturation and could result in adverse effects on sperm quality [ 63 ].…”

Section: Discussionmentioning

confidence: 99%

Multiple Xenosteroid Pollutants Biomarker Changes in Cultured Nile Tilapia Using Wastewater Effluents as Their Primary Water Source

Zahran

Elmetwally

Awadin

et al. 2020

Animals

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This study was undertaken to screen levels of xenosteroids (estrogenic endocrine disrupting chemicals/E-EDCs) in Nile tilapia (Oreochromis niloticus) fish farms subjected to water fill from the drain at three sites S1 (highly polluted), S2 (moderately polluted), and a putative reference site (RS). Biometric, hormonal, gene expression, and histopathological analysis were investigated. Testosterone, progesterone, and zeranol residues were detected at (0.12–3.44 µg/L) in water samples of different sites. Bisphenol-A (BPA) exhibited a very high concentration (6.5 µg/mL) in water samples from S1. Testosterone, 17β-estradiol residues were detected in fish tissues from all sites at (0.16–3.8 µg/Kg) and (1.05–5.01 µg/Kg), respectively. BPA residues were detected at a very high concentration in the liver and muscle of fish collected from S1 at higher levels of 25.9 and 48.07 µg/Kg, respectively. The detected E-EDCs, at different sites, particularly BPA, reduced the somatic and testicular growth among sites and oversampling time points. Meanwhile, hepatosomatic index (HSI) was significantly increased in S1 compared to S2. All analyzed genes estrogen receptor-type I (er-I, er-ɑ) and II (er-II, er-ß1), polypeptide 1a (cyp19a1), SRY-box containing gene 9 (sox9), and vitellogenin (vtg) and gonadotropin hormones (luteinizing hormone (LH), follicle-stimulating hormone (FSH)), testosterone, 17β-estradiol, and anti-Mullerian hormone (AMH) were significantly expressed at S1 compared to other sites. Histopathology was more evident in S1 than other sites. These findings warrant immediate strategies development to control aquatic pollution and maintain fish welfare and aquaculture sustainability.

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Adverse effects of bisphenol A on the testicular parenchyma of zebrafish revealed using histomorphological methods

Cited by 19 publications

References 30 publications

Histopathological study of the Achilles tendon after exposure to bisphenol-A and its subsequent treatment with platelet growth factors

Histopathological study of the Achilles tendon after exposure to bisphenol-A and its subsequent treatment with platelet growth factors

Xenosteroids in aquaculture with special consideration to Lake Manzala (Northern delta lake, Egypt): Types, sources and mechanism of action

Multiple Xenosteroid Pollutants Biomarker Changes in Cultured Nile Tilapia Using Wastewater Effluents as Their Primary Water Source

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