Adverse effects and treatment satisfaction among online users of four antidepressants

Hughes, Shannon; Lacasse, Jeffrey R.; Fuller, Reid Rogers; Spaulding-Givens, Jennifer

doi:10.1016/j.psychres.2017.05.021

Cited by 35 publications

(39 citation statements)

References 22 publications

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“…and 'Work or study'). A recent examination of over 3,000 online comments by AD users found that 'Emotional and behavioral' adverse effects were reported far more than biological/medical effects such as Cardiovascular, Gastrointestinal or Metabolic [27]. All these findings contrast with more traditional studies of adverse effects, such as drug trials which have focussed, like most officially sanctioned checklists, on the adverse biological/medical effects [9][10][11].…”

Section: Discussionmentioning

confidence: 97%

Adverse Effects of Antidepressants Reported by a Large International Cohort: Emotional Blunting, Suicidality, and Withdrawal Effects

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Williams

2018

CDS

133

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Asking people directly reveals far higher rates of adverse responses to antidepressants than previously understood, especially in the emotional, psychological and interpersonal domains. Given recent findings that antidepressants are only marginally more effective than placebo, the findings of the current study imply a cost-benefit analysis that cannot justify the extremely high prescription rates for these drugs.

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Section: Discussionmentioning

confidence: 97%

Adverse Effects of Antidepressants Reported by a Large International Cohort: Emotional Blunting, Suicidality, and Withdrawal Effects

Read

Williams

2018

CDS

133

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“…Furthermore, the side effects of vortioxetine differ from those of other antidepressants, according to the low incidence of sexual dysfunction and weight gain (Salagre et al, 2018). Conversely, reports of gastrointestinal side effects, particularly nausea, seem to be highly associated with vortioxetine, mainly at the beginning of the treatment (Hughes, Lacasse, Fuller, & Spaulding‐Givens, 2017).…”

Section: Introductionmentioning

confidence: 99%

Effectiveness, tolerability, and dropout rates of vortioxetine in comorbid depression: A naturalistic study

Carlo

Vismara

Grancini

et al. 2020

Human Psychopharmacology

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Objective Vortioxetine is a novel antidepressant whose safety, tolerability, and therapeutic action have been supported by several studies. The present naturalistic study aimed to characterize its effectiveness, tolerability, and dropout rate in the real world. Methods Total sample consisted of 66 outpatients with major depressive episode, treated with vortioxetine, whose clinical variables were evaluated over three time points. Results Most common primary diagnoses were major depressive disorder (45.5%) and bipolar disorder (33.4%), with an overall comorbidity rate of 48.5% and concomitant medications in the 89.4%. The mean vortioxetine daily dosage was 12.90 ± 5.65 mg. Effectiveness of vortioxetine through a significant improvement on specific psychometric scales emerged, while only a nonsignificant trend of association between higher dosage and effectiveness was found. In the total sample, 51.5% were classified as responders and 36.4% as remitters. Two‐thirds of subjects did not report side effects, while in the remaining patients, gastrointestinal ones were the most frequent (72.7%). Almost two‐thirds of the sample could complete the follow‐up, while 36.4% dropped out; the main reasons for dropout were side effects (37.5%) and lack of efficacy (29.2%). Conclusions Larger sample studies are warranted to better characterize vortioxetine effectiveness and tolerability in the real world.

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“…Selected publications suggest that the effect of antidepressant treatment is indeed the same as the active placebo response, which takes place when the patient experiences side effects of taken medications (Kirsch, 2014). It is underlined that antidepressants cause a number of easily noticeable side effects, such as dry mouth (xerostomia), drowsiness, anxiety, and low libido (e.g., Hughes, Lacasse, Fuller, & Paulding-Givens, 2017). It is suggested that if a patient discovers one of these side effects, they conclude that they are in the study group receiving the active substance, and not the placebo (Rabkin et al, 1986), which affects their expectations of the effectiveness of the treatment.…”

Section: Active Placebo Response Hypothesismentioning

confidence: 99%

Twenty years after ‘Listening to Prozac but hearing placebo’. Do we hear placebo even louder?

Oronowicz-Jaśkowiak¹,

Bąbel²

2019

Health Psychology Report

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health psychology report • volume 7(1), 9 review article An active placebo is a substance that produces side effects similar to an active ingredient while not producing the same intended therapeutic effect. The aim of this study is to review the literature on the hypothesis of the active placebo response as a mechanism of action of antidepressants. It was found that persons who expect the occurrence of side effects of a pure placebo taken under the guise of an antidepressant present a higher degree of depressive symptoms than persons who do not expect the occurrence of side effects. There are reasons to believe that the entirety or part of the difference in the effectiveness of antidepressants and placebo is due to the fact that participants of the clinical trials correctly guess which study group they have been assigned to.

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Adverse effects and treatment satisfaction among online users of four antidepressants

Cited by 35 publications

References 22 publications

Adverse Effects of Antidepressants Reported by a Large International Cohort: Emotional Blunting, Suicidality, and Withdrawal Effects

Adverse Effects of Antidepressants Reported by a Large International Cohort: Emotional Blunting, Suicidality, and Withdrawal Effects

Effectiveness, tolerability, and dropout rates of vortioxetine in comorbid depression: A naturalistic study

Twenty years after ‘Listening to Prozac but hearing placebo’. Do we hear placebo even louder?

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