Adverse effect of splenectomy on recurrence in total gastrectomy cancer patients with perioperative transfusion

Shen, Ju; Cheong, Jae‐Ho; Hyung, Woo Jin; Kim, Junuk; Choi, Seung Ho; Noh, Sung Hoon

doi:10.1016/j.amjsurg.2006.04.014

Cited by 28 publications

(19 citation statements)

References 17 publications

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“…Although perioperative transfusion was not an independent risk factor for prognosis in multivariate analysis, it was marginally significant (P ¼ 0.054, odds ratio, 1.427; 95% CI, 0.993-2.051). In other studies, perioperative transfusion in a patient undergoing an operation for a malignancy was associated with high tumor recurrence and poor survival [16][17][18]. This may be due to the immunosuppressive findings after transfusion, which are as follows: decreased helper/suppressor T-cell ratio, decreased natural killer cells, decreased macrophage antigen presentation, and suppression of lymphocyte blastogenesis [19].…”

Section: Discussionmentioning

confidence: 95%

The effect of spleen‐preserving lymphadenectomy on surgical outcomes of locally advanced proximal gastric cancer

Hyung

et al. 2009

Journal of Surgical Oncology

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Section: Discussionmentioning

confidence: 95%

The effect of spleen‐preserving lymphadenectomy on surgical outcomes of locally advanced proximal gastric cancer

Hyung

et al. 2009

Journal of Surgical Oncology

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“…Total or distal subtotal gastrectomy was performed depending on the location and macroscopic type of gastric cancer. Splenectomy was not routinely performed unless direct tumor invasion to the spleen was suspected or in case of accidental injury during operation [7]. D2 or more than D2 lymphadenectomy was usually performed according to the rules of the Japanese Research Society for Gastric Cancer (JRSGC) [8].…”

Section: Methodsmentioning

confidence: 99%

Ulcer Size as a Novel Indicator Marker Is Correlated with Prognosis of Ulcerative Gastric Cancer

Shen

et al. 2009

Dig Surg

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Aims: The objective of this study was to assess the significance of ulcer size for the survival of gastric cancer patients. Methods: A total of 260 patients with ulcerative gastric cancer who had undergone curative resection were reviewed. The diameter of the malignant ulcer was measured. Patients were divided into group U1 (≤3 cm) and group U2 (>3 cm) according to the diameter of the ulcer. The prognostic significance of ulcer size was assessed by uni- and multivariate analyses. Results: Patient survival was correlated with age, gender, tumor location, tumor size, ulcer size, serosal invasion, node involvement and synchronism distant metastasis. The 5-year overall survival rate in U1 patients was 84.3% as compared with 67.5% in U2 patients (p < 0.001), and the 5-year recurrence-free survival rates were 82.9% for group U1 and 62.5% for group U2 (p = 0.001). Multivariate analysis revealed that ulcer size is an independently significant predictive factor for survival rates (overall: hazard ratio 1.222, p = 0.003; recurrence-free: hazard ratio 1.205, p = 0.006). Conclusion: Ulcer size might be a potential indicator for advanced disease and the use of minimal local treatments must be considered carefully in larger ulcer size patients.

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“…Splenectomy was only performed if there was a suspicion of direct tumour invasion into the spleen, or accidental injury to the spleen occurred during the operation. 14,15 All resected tissues were examined according to a standardized histopathological protocol, with evaluation of the TNM stage according to the 6th American Joint Committee on Cancer/Union Internationale Contre le Cancer (AJCC/UICC). 9 Depth of invasion was determined by examining the deepest portion of gastric wall invasion.…”

Section: Surgical Interventionmentioning

confidence: 99%

Reduced Lymph Node Harvest after Neoadjuvant Chemotherapy in Gastric Cancer

et al. 2011

J Int Med Res

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This retrospective study investigated the impact of neoadjuvant chemotherapy on the number of lymph nodes harvested in patients with T 3 /T 4 gastric cancer. Lymph node counts in 58 patients who received preoperative neoadjuvant chemotherapy were compared with those in 168 patients who received surgery alone. Significantly more patients (n = 14, 24.1%) treated with neoadjuvant chemotherapy had < 15 lymph nodes harvested compared with patients (n = 13, 7.7%) treated with surgery alone. A significant correlation between the total number of harvested lymph nodes and the number of metastatic lymph nodes (mLNs) existed in both groups. Neoadjuvant chemotherapy was the only factor associated with the retrieval of < 15 lymph nodes. The number of mLNs was an independent predictive factor for overall survival.Although neoadjuvant chemotherapy decreased the number of lymph nodes harvested, the number of mLNs may still be an acceptable prognostic factor in patients with gastric cancer, following neoadjuvant chemotherapy.

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Adverse effect of splenectomy on recurrence in total gastrectomy cancer patients with perioperative transfusion

Cited by 28 publications

References 17 publications

The effect of spleen‐preserving lymphadenectomy on surgical outcomes of locally advanced proximal gastric cancer

The effect of spleen‐preserving lymphadenectomy on surgical outcomes of locally advanced proximal gastric cancer

Ulcer Size as a Novel Indicator Marker Is Correlated with Prognosis of Ulcerative Gastric Cancer

Reduced Lymph Node Harvest after Neoadjuvant Chemotherapy in Gastric Cancer

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