Adverse effect of paroxetine on sperm

Tanrikut, Cigdem; Feldman, Adam S.; Altemus, Margaret; Paduch, Darius A.; Schlegel, Peter N.

doi:10.1016/j.fertnstert.2009.04.039

Cited by 178 publications

(128 citation statements)

References 25 publications

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“…11 They observed further detrimental effects by SSRIs on semen parameters (count, motility and morphology) when the duration of treatment was extended and suggested that neuroendocrine factors have a central role in SSRI effects on spermatozoa. 11 In a prospective study, Tanrikut et al 12 assessed semen analyses and sperm DNA integrity in 35 healthy men before receiving paroxetine for 5 weeks. After 5 weeks of paroxetine administration, higher DNA fragmentation rates were detected without any significant changes in other semen parameters.…”

Section: Adverse Effects Of Ssri On Semen Parametersmentioning

confidence: 99%

Deleterious effects of selective serotonin reuptake inhibitor treatment on semen parameters in patients with lifelong premature ejaculation

Koyuncu

Şerefoğlu

Özdemır³

et al. 2012

Int J Impot Res

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Premature ejaculation (PE), the most common sexual dysfunctions in men, is characterized by loss or absence of ejaculatory control. PE can be classified as either a lifelong or acquired condition. Although the prevalence of lifelong PE is rather low in the general male population, recent studies demonstrated that the patients who seek treatment for their rapid ejaculation mostly report lifelong PE. Although no drug for PE has been approved by regulatory bodies, chronic selective serotonin reuptake inhibitors (SSRIs) proved to be effective in treating lifelong PE. Despite the rising use and known effects of antidepressants on ejaculation, only a few reports have evaluated the impact of these drugs on the male fertility. Thus, the aim of this review is to evaluate the efficacy and adverse effects of SSRIs on semen parameters of patients with lifelong PE as well as to assess the safety of this treatment among sexually active couples who desire to have a child.

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Section: Adverse Effects Of Ssri On Semen Parametersmentioning

confidence: 99%

Deleterious effects of selective serotonin reuptake inhibitor treatment on semen parameters in patients with lifelong premature ejaculation

Koyuncu

Şerefoğlu

Özdemır³

et al. 2012

Int J Impot Res

View full text Add to dashboard Cite

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“…Another study showed abnormal DNA fragmentation in sperm caused by paroxetine [5]. Abnormal DNA fragmentation can lead to diminished fertility and is associated with an increased risk of diseases in the offspring [6].…”

mentioning

confidence: 99%

“…Regulatory authorities had reason for concern regarding drug use by fathers based on studies and case reports for products such as selective serotonin reuptake inhibitors (SSRIs) [5] and finasteride [4].…”

mentioning

confidence: 99%

Paternal drug use: before and during pregnancy

Crijns

Bos

Knol

et al. 2012

Expert Opinion on Drug Safety

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“…After 5 weeks paroxetine administration testosterone and estrogen levels decreased significantly whereas higher DNA fragmentation was detected. Interestingly, Tanrikut et al 11 did not observe any significant changes in semen parameters and advocated their previous hypothesis, which suggests that impairment in sperm transport may cause alterations in sperm DNA integrity without doing any changes in sperm count. However, the duration of paroxetine administration was only 35 days in this study and is not sufficient for evaluating the impact of any medication on sperm production, which takes 74 days.…”

Section: Discussionmentioning

confidence: 90%

“…8 As no universal agreement has been reached on how long SSRIs must be employed to treat PE so as to get ideal effect, there are limited data regarding the adverse effects of long-term SSRI treatment in PE patients. 9 Although there are only a few studies, which determined the negative effect of SSRIs on semen parameters of depressed men or healthy volunteers, 10,11 to our knowledge, the impact of this treatment on semen parameters of lifelong PE patients has not been evaluated yet.…”

Section: Introductionmentioning

confidence: 99%

Escitalopram treatment for premature ejaculation has a negative effect on semen parameters

et al. 2011

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The aim of this study was to determine the impact of long-term escitalopram treatment on semen parameters of patients with lifelong premature ejaculation (PE). Between November 2008 and January 2010, patients admitted to urology outpatient clinic with a self-reported complaint of PE were evaluated. Medical and sexual history of patients were recorded and patients with lifelong PE (a total of 25 patients) who met the International Society of Sexual Medicine definition were asked to record their intravaginal ejaculatory latency time (IELT) for 1 month, complete Premature Ejaculation Diagnostic Tool (PEDT) questionnaire and give semen samples. Afterwards, patients received 10 mg escitalopram daily for 12 weeks and were invited for control visits at first and third month of treatment. During control visits, PEDT was administered again whereas IELTs were recorded and semen samples were re-examined. PEDT scores, arithmetic means of IELTs and results of semen analyses, which were recorded at baseline, first and third month were compared. At the third month of treatment, a significant increase in mean IELTs and a significant decrease in PEDT scores were detected. However there was a significant decrease in sperm concentration, motility and morphology when compared with the baseline semen measures. Daily escitalopram treatment effects the semen parameters of patients with lifelong PE. Further investigations with larger series are needed to see whether other serotonin reuptake inhibitors have similar side effects and to expose the exact mechanism underlying it. Different treatment modalities should be suggested to patients who desire fertility.

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Adverse effect of paroxetine on sperm

Cited by 178 publications

References 25 publications

Deleterious effects of selective serotonin reuptake inhibitor treatment on semen parameters in patients with lifelong premature ejaculation

Deleterious effects of selective serotonin reuptake inhibitor treatment on semen parameters in patients with lifelong premature ejaculation

Paternal drug use: before and during pregnancy

Escitalopram treatment for premature ejaculation has a negative effect on semen parameters

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