Adverse drug reactions in paediatric patients in a tertiary care hospital in India: a prospective observational single centre study

Divyalasya, T V S; Krishnaiah, Vasundara; Yashoda, H T; Pundarikaksha, H P; Kudagi, B. L.; Pathapati, Ramamohan

doi:10.18203/2319-2003.ijbcp20163249

Cited by 1 publication

(5 citation statements)

References 18 publications

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“…The majority of ADRs (88.89%) in our study were definitely preventable, followed by probable preventable (11.11). Our finding is in contrast to the study done by Kalyani et al and Divyalasya TVS et al [4,19].…”

Section: Discussioncontrasting

confidence: 99%

“…According to the WHO-UMC causality assessment, it was found that the majority of ADRs were probable (87.5%), followed by possible (6.94%), certain (4.18%), and unlikely (1.38%). Similarly, results were found in a study done by Divyalasya et al [4].…”

Section: Discussionsupporting

confidence: 83%

“…As per this result, fewer numbers of ADRs were reported from neonates and infants as compared to the children age group. A dissimilar study was conducted by Divyalasya et al [4]. Most of the ADRs were reported in neonates and infants.…”

Section: Discussionmentioning

confidence: 97%

“…In this study, the majority of ADRs were non-serious (84.72%), and only (15.28%) of them were found serious with prolonged hospitalization. [4,20].…”

Section: Discussionmentioning

confidence: 99%

“…Past study outcomes as a result of the incidence of ADRs causing hospital admission in children range from 0.4 to 10.3%, and their occurrence in hospitalized children is 0.6-16.8%. The overall incidence of ADRs in children is 2.9% [4]. Globally, ADR can lead to significant morbidity among children and have relatively more severe effects compared to adults.…”

Section: Introductionmentioning

confidence: 99%

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A Retrospective Study: Analysis of Adverse Drug Reaction in Pediatric Patients in a Tertiary Care Hospital

Mathur

MISHRA²

2022

Asian J Pharm Clin Res

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Objective: The objective of this study was to analyze various parameters such as admission type, demographics, type of reaction, organ system classification, drugs involved, action is taken, reaction outcome, causality assessment, severity assessment, and the preventability of Adverse drug reactions (ADRs) in pediatric patients. Methods: This retrospective observational study was conducted during the period of September 2017 to June 2020 (34 months) at the ADR monitoring center, Department of Pharmacology, Jawaharlal Nehru Medical College, Ajmer, Rajasthan. All spontaneously reported ADRs were evaluated using various parameters such as type of reaction, causality assessment, preventability, and severity. Results: In the present study, 72 (7.27%) ADRs were reported in relation to 65 pediatric patients. In this study, more ADRs were reported in male (53.85%) as compared to female (46.15%) pediatric patients. The majority of ADRs were considered type B (63.89%), probable (87.5%), moderate (51.39%), and definitely preventable (88.89%) in nature. The majority of ADRs were reported due to antimicrobial classes of drugs, including anthelmintic drug (Albendazole), followed by glycopeptide antibiotic (Vancomycin) and third-generation cephalosporin antibiotics (Ceftriaxone, Cefotaxime, and Cefixime). The organ systems most commonly affected were skin and subcutaneous tissue disorders (47.22%), followed by general disorders and administration site conditions (20.83%) and gastrointestinal disorders (16.67%). Conclusion: The present study 30 different types of suspected ADRs that were reported with multiple frequencies, with included 34 different categories of drugs and combinations of drugs. The majority of patients recovered, with associated ADR, after necessary medical intervention and management. Our purpose is to minimize the incidence rate of ADRs in the pediatric population.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 97%

“…In this study, the majority of ADRs were non-serious (84.72%), and only (15.28%) of them were found serious with prolonged hospitalization. [4,20].…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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