Adverse drug reactions and polypharmacy in cardiac patients

Mugosa, Snezana; Todorović, Zoran; Sahman-Zaimovic, Majda

doi:10.1186/2050-6511-13-s1-a39

Cited by 2 publications

(2 citation statements)

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“…23 There are also reports stating a higher incidence of ADRs in contrast with the present findings. [24][25] In 3.88% of cases, patients were hospitalized due to ADRs which was supported by a study conducted by Arulmani et al (3.4%). 26 However, a higher incidence (6.4%) was seen in a study carried out by Kaur et al 18 There were 60 patients (19.42%) who developed a total of 93 ADRs during their hospital stay.…”

Section: Discussionmentioning

confidence: 53%

“…The finding of the present study is comparable to that of earlier studies where polypharmacy was the only predictor for ADRs. 25,34 On evaluation of drug class implicated in ADRs, betablockers (14.68%) were the most common drug class followed by Renin-Aldosterone-Angiotensen-Receptors (RAAS) blockers and anti-coagulants. The present findings are similar to the findings reported in studies conducted by Haile et al and Chan et al 3,31 In contrast to these findings, a study conducted by Rohit et al reported that calcium channel blockers were the most common drug class involved in ADRs.…”

Section: Discussionmentioning

confidence: 99%

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Monitoring and Reporting of Adverse Drug Reactions Due to Cardiovascular Drugs in Patients Admitted to a Secondary Care Hospital in Northern Emirate- a Prospective Surveillance Study

Wadhwa¹,

Sheikh²,

Rao³

2018

IJOPP

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Context: Adverse drug reactions (ADRs) can result in a number of consequences, ranging from allergic reactions to permanent harm thereby causing morbidity and mortality leading to an increase in the health care costs. Aims: The main objective of the present study was to assess the prevalence of adverse drug reactions due to cardiovascular drugs in patients admitted to a secondary care hospital. Material and Methods: This was a prospective surveillance study which included adult patients of either gender who were hospitalized and prescribed with at least one cardiovascular drug. Patients were monitored from the day of admission till the day of discharge for the occurrence of ADRs due to cardiovascular drugs by attending clinical meetings, ward rounds, reviewing patients' medical records and electronic medical records. Results: A total of 309 patients were enrolled in the present study. Among them, 72 patients experienced 109 ADRs accounting for an incidence of 23.3%. Twelve (3.88%) patients were hospitalized due to ADRs (n=16) whereas 60 (19.41%) patients developed ADRs (n=93) during their hospital stay. Male preponderance was observed over female. Patients with age ≥ 60 years experienced 73 ADRs. The most common drug class implicated in ADRs was observed to be beta blockers (18; 16.5%) especially bisoprolol (16; 14.68%). Majority of patients experienced bradycardia (11; 10.09%) followed by hypotension (9; 8.26%). Cardiovascular system (30; 27.53%) was observed to be the most common system. Majority of ADRs were possible (80; 73.39%) in nature, mild (53%) in severity and not preventable (84.5%). Conclusion: Intensive approach towards monitoring and reporting of ADRs could help healthcare professionals in minimizing preventable ADRs.

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Section: Discussionmentioning

confidence: 53%

Section: Discussionmentioning

confidence: 99%

Monitoring and Reporting of Adverse Drug Reactions Due to Cardiovascular Drugs in Patients Admitted to a Secondary Care Hospital in Northern Emirate- a Prospective Surveillance Study

Wadhwa¹,

Sheikh²,

Rao³

2018

IJOPP

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Adverse effects of interactions between antidepressants and medications used in treatment of cardiovascular disorders

Woroń¹,

Siwek²,

Gorostowicz³

2019

Psychiatr Pol

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Cel pracyOcena występowania niekorzystnych interakcji leków przeciwdepresyjnych (LPD) z lekami stosowanymi w chorobach układu krążenia (leki krążeniowe - LK)MetodaAnaliza 66 przypadków wystąpienia objawów niepożądanych, o obrazie klinicznym wskazującym w stopniu prawdopodobnym lub pewnym, że były one skutkiem połączenia LPD z LKWynikiNajczęstszym niepożądanym efektem (n=25 – tj. 37.9%) było wystąpienie bradykardii (i innych działań niepożądanych betablokerów) w następstwie dołączenia metoprololu lub propranololu do leku z grupy SSRI lub bupropionu. W jednym przypadku połączenie fluoksetyny z propranololem skutkowało zatrzymaniem krążenia. Zanotowano 8 przypadków nasilenia działań niepożądanych amlodypiny (obrzęki kończyn dolnych, bóle głowy) po połączeniu z: fluoksetyną, sertraliną lub paroksetyną, oraz wystąpienie mialgii, elewacji aminotransferaz, wielomoczu i hipotensji w połaczeniu lerkarnidypiny niektórymi SSRI. Stwierdzono też m.in: pogorszenie tolerancji propafenonu o połączeniu z wenlafaksyną lub bupropionem, 2 przypadki granulopenii związane z kombinacją duloksetyna -propafenon, 2 przypadki powikłań krwotocznych związanych z kombinacją wortioksetyna- warfaryna, 1 przypadek hiponatremii związany z połączeniem wortioksetyny i chydrochlorotiazydu, a także antagonizowanie dziłania hipotensyjnego klonidyny przez mirtazapinę i zakrzepicę obwodową w następstwie połączenia warfaryny z trazodonem.WnioskiZe względu na wysokie ryzyko interakcji i związanych z nimi efektów niepożądanych, zwłaszcza u pacjentów w starszym wieku, każda decyzja dotycząca połączenia określonego LPD i LK powinna być poprzedzona szczegółową analizą bezpieczeństwa oraz bilansu korzyści i ryzyka a także powinna wiązać się z poszukiwaniem najbardziej bezpiecznych, alternatywnych kombinacji ww leków.

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Adverse drug reactions and polypharmacy in cardiac patients

Abstract: Background Adverse drug reactions (ADR) appear more frequently then what is actually reported and registered. The aim was to establish an intensive monitoring system and to analyze ADR in hospitalized patients.

Cited by 2 publications

References 0 publications

Monitoring and Reporting of Adverse Drug Reactions Due to Cardiovascular Drugs in Patients Admitted to a Secondary Care Hospital in Northern Emirate- a Prospective Surveillance Study

Monitoring and Reporting of Adverse Drug Reactions Due to Cardiovascular Drugs in Patients Admitted to a Secondary Care Hospital in Northern Emirate- a Prospective Surveillance Study

Adverse effects of interactions between antidepressants and medications used in treatment of cardiovascular disorders

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