Monitoring and Reporting of Adverse Drug Reactions Due to Cardiovascular Drugs in Patients Admitted to a Secondary Care Hospital in Northern Emirate- a Prospective Surveillance Study

Abstract

Context: Adverse drug reactions (ADRs) can result in a number of consequences, ranging from allergic reactions to permanent harm thereby causing morbidity and mortality leading to an increase in the health care costs. Aims: The main objective of the present study was to assess the prevalence of adverse drug reactions due to cardiovascular drugs in patients admitted to a secondary care hospital. Material and Methods: This was a prospective surveillance study which included adult patients of either gender who were hospitalized and prescribed with at least one cardiovascular drug. Patients were monitored from the day of admission till the day of discharge for the occurrence of ADRs due to cardiovascular drugs by attending clinical meetings, ward rounds, reviewing patients' medical records and electronic medical records. Results: A total of 309 patients were enrolled in the present study. Among them, 72 patients experienced 109 ADRs accounting for an incidence of 23.3%. Twelve (3.88%) patients were hospitalized due to ADRs (n=16) whereas 60 (19.41%) patients developed ADRs (n=93) during their hospital stay. Male preponderance was observed over female. Patients with age ≥ 60 years experienced 73 ADRs. The most common drug class implicated in ADRs was observed to be beta blockers (18; 16.5%) especially bisoprolol (16; 14.68%). Majority of patients experienced bradycardia (11; 10.09%) followed by hypotension (9; 8.26%). Cardiovascular system (30; 27.53%) was observed to be the most common system. Majority of ADRs were possible (80; 73.39%) in nature, mild (53%) in severity and not preventable (84.5%). Conclusion: Intensive approach towards monitoring and reporting of ADRs could help healthcare professionals in minimizing preventable ADRs.

Prescribing pattern and adverse drug reactions of cardiovascular drugs in out-patient department of a tertiary care hospital

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Adverse drug reactions monitoring of anticoagulant drugs used in cardiac coronary care unit of a tertiary care hospital

“…Earlier studies have revealed higher incidences (59.54%) of ADRs in patients of >60 years of age than any other age group. 16 The higher number of ADRs in the old age can be due to the altered pharmacokinetics like a decline in renal function and hepatic function.…”

Acute Coronary Syndrome – Exploring the Evidences Clinical Pharmacist Driven Cardiac Review

“…Bisoprolol was the most common drug implicated in causing ADRs, specifically, bradycardia as an adverse effect. 31 According to a news article published in Khaleej times in April 19, 2017, there is a significant increase in the number of cases of adverse drug reactions in UAE. Ministry of Health and Prevention, UAE noticed increase number of ADR cases varying from 59 in 2013 to 825 in 2016.…”