Adverse childhood experiences and premature all-cause mortality

Kelly-Irving, Michelle; Lepage, Benoît; Dedieu, Dominique; Bartley, Mel; Blane, David; Grosclaude, Pascale; Lang, Thierry; Delpierre, Cyrille

doi:10.1007/s10654-013-9832-9

Cited by 248 publications

(226 citation statements)

References 35 publications

(40 reference statements)

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“…In this context, the study of the relationship between ACE and AL can contribute to a better understanding of early origins of disease and social gradient in health. Recently, Kelly-Irving et al (28,29) showed an association between ACE and self-reported cancer as well as mortality, after adjusting for behavioral and socioeconomic factors suggesting …”

Section: Discussionmentioning

confidence: 99%

“…Lately, epidemiological studies have shown that ACEs were associated with mortality and health even after adjusting for socioeconomic and behavioral factors, suggesting that a direct biological effect occurring from early life is plausible (28,29). It has been suggested that psychosocial factors could protect and buffer early adverse circumstances, such as parental warmth and psychological resources, reducing physiological responses and mitigating disease processes (30,31).…”

Section: Significancementioning

confidence: 99%

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Adverse childhood experiences and physiological wear-and-tear in midlife: Findings from the 1958 British birth cohort

Solís

Kelly-Irving

Fantin

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

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165

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Allostatic load (AL) is a measure of overall physiological wear-andtear over the life course, which could partially be the consequence of early life exposures. AL could allow a better understanding of the potential biological pathways playing a role in the construction of the social gradient in adult health. To explore the biological embedding hypothesis, we examined whether adverse childhood experiences (ACEs) are associated with elevated AL in midlife. We used imputed data on 3,782 women and 3,753 men of the National Child Development Study in Britain followed up seven times. ACEs were measured using prospective data collected at ages 7, 11, and 16. AL was operationalized using data from the biomedical survey collected at age 44 on 14 parameters representing four biological systems. We examined the role of adult health behaviors, body mass index (BMI), and socioeconomic status as potential mediators using a path analysis. ACEs were associated with higher AL for both men and women after adjustment for early life factors and childhood pathologies. The path analysis showed that the association between ACEs and AL was largely explained by early adult factors at age 23 and 33. For men, the total mediated effect was 59% (for two or more ACEs) via health behaviors, education level, and wealth. For women, the mediated effect represented 76% (for two or more ACEs) via smoking, BMI, education level, and wealth. Our results indicate that early psychosocial stress has an indirect lasting impact on physiological wear-and-tear via health behaviors, BMI, and socioeconomic factors in adulthood.allostatic load | adverse childhood experiences | biological embedding | health behaviors | cohort study

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Section: Discussionmentioning

confidence: 99%

Section: Significancementioning

confidence: 99%

Adverse childhood experiences and physiological wear-and-tear in midlife: Findings from the 1958 British birth cohort

Solís

Kelly-Irving

Fantin

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

165

105

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“…No increased mortality between age 27 and 69 y was found in the 1,726 members of the Helsinki Birth Cohort (born 1934-1944 and followed from 1971-2003) who were separated as children from their parents during the Second World War (32). In the 1958 British birth cohort, increased all-cause mortality before age 50 y was found for the 4,543 individuals who experienced events such as parental divorce or bereavement in early life (33).…”

mentioning

confidence: 92%

“…For instance, males born at the height of the Finnish famine lost ∼1 y of life expectancy at age 40 y (29). To our knowledge, only two studies have related early psychological stress and adult mortality (32,33). No increased mortality between age 27 and 69 y was found in the 1,726 members of the Helsinki Birth Cohort (born 1934-1944 and followed from 1971-2003) who were separated as children from their parents during the Second World War (32).…”

mentioning

confidence: 96%

Prenatal loss of father during World War One is predictive of a reduced lifespan in adulthood

Todd

Valleron

Bougnères

2017

Proc. Natl. Acad. Sci. U.S.A.

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Although early-life stress is known to alter health, its long-term consequences on mortality remain largely unknown. Thanks to unique French legislation established in 1917 for war orphans and children of disabled soldiers, we were able to study the adult mortality of individuals born in 1914–1916 whose fathers were killed during World War 1. Vital information and socio-demographic characteristics were extracted manually from historical civil registers for 5,671 children born between 1 August 1914 and 31 December 1916 who were granted the status of “pupille de la Nation” (orphan of the Nation). We used a database comprising 1.4 million deceased soldiers to identify war orphans and collect information on their fathers and then paired each orphan with a nonorphan from the same birth register matched for date of birth, sex, and mother’s age at the infant’s birth. Mortality between ages 31 and 99 y was analyzed for 2,365 orphan/nonorphan pairs. The mean loss of adult lifespan of orphans who had lost their father before birth was 2.4 y (95% CI: 0.7, 3.9 y) and was the result of increased mortality before age 65 y. Adult lifespan was not reduced when the father’s death occurred after the infant’s birth. These results support the notion that intrauterine exposure to a major psychological maternal stress can affect human longevity.

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“…Faire la part des différentes expositions englobées dans ce terme de niveau socioéconomique précoce reste un enjeu important. Des travaux ont récemment mis en évidence le lien entre l'adversité durant l'enfance, incluant les abus (physiques, sexuels, émotionnels), les négligences (physiques, émotionnelles) ou des dysfonctionnements familiaux, et le risque de mortalité prématurée [9] ou de cancer [10] à l'âge adulte. Ce lien était certes atténué après prise en compte des facteurs de confusion -tels que l'environnement pré-et périnatal -, et de médiation à l'âge adulte -tels que les comportements à risque, la santé mentale ou le niveau socioéconomique -, mais il persistait, rendant plausible un effet biologique précoce de l'adversité qui reste à expliciter.…”

Section: Les Enjeux Liés Aux Modifications Du Statut Nutritionnel Matunclassified

DOHaD

Delpierre¹,

Lepeule

Cordier

et al. 2016

Med Sci (Paris)

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Adverse childhood experiences and premature all-cause mortality

Cited by 248 publications

References 35 publications

Adverse childhood experiences and physiological wear-and-tear in midlife: Findings from the 1958 British birth cohort

Adverse childhood experiences and physiological wear-and-tear in midlife: Findings from the 1958 British birth cohort

Prenatal loss of father during World War One is predictive of a reduced lifespan in adulthood

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