Adverse cardiovascular outcomes and their relationship with risk factors according to the prospective study MERIDIAN-RO

Филиппов, Е. В.; Воробьев, А. Н.; Добрынина, Н. В.; Zotova, L A; Лыгина, Е В; Никулина, Н. Н.; Селезнев, С. В.; Якушин, С. С.

doi:10.15829/1560-4071-2019-6-42-48

Cited by 6 publications

(2 citation statements)

References 8 publications

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“…Оренбург; 10 Научно-исследовательский институт кардиологии ФГБОУ ВО "Самарский государственный медицинский университет" Минздрава России. Самара; 11 ФГБУ "Национальный медицинский исследовательский центр им. В. А. Алмазова" Минздрава России.…”

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Contribution of hypertension and other risk factors to survival and mortality in the Russian population

Баланова¹,

Шальнова²,

Куценко

et al. 2021

Cardiovasc Ther Prev

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Aim. To study the contribution of hypertension (HTN) to survival and mortality in the Russian population.Material and methods. This prospective observational cohort included representative samples from 11 Russian regions (men and women aged 25-64 years, n=18251) examined in 2012-2014 as part of the Epidemiology of Cardiovascular Diseases and their Risk Factors in Regions of Russian Federation (ESSE-RF) study. The examination included a questionnaire (12 modules), anthropometric and blood pressure (BP) measurements, as well as biochemical blood tests. HTN was considered aa a systolic BP ≥140 mm Hg and/or diastolic BP ≥90 mm Hg, or when a subject receives antihypertensives. Treatment efficacy was considered as the proportion of persons (%) who achieved target BP among those taking antihypertensives. Depending on HTN status, all participants were divided into 4 groups: 1) those without HTN;2) those with HTN, taking antihypertensive agents and having systolic BP ≤140 mm H. and diastolic BP ≤90 mm Hg (effective therapy);3) those with HTN, taking medications, but not achieving target BP (ineffective therapy); 4) those with HTN, not taking antihypertensives. The life status of participants was updated every 2 years. Kaplan-Meier survival curves, as well as univariate and multivariate Cox proportional hazards models were created.Results. The presence of HTN significantly reduced survival (p<0,001) in the cohort, which is significant when adjusted for age (men — relative risk (RR)=1,47, p<0,001, women — RR=1,17, p<0,001). In the multivariate model, the male sex (RR=2,3 p<0,001), age increase, smoking, tachycardia, and HTN are significant for all-cause mortality only for men, but not for women. However, for women, absence of higher education was significant. The presence of HTN significantly worsens cardiovascular survival in both sexes (p<0,0001). HTN increases the risk of a composite endpoint for both men and women (p<0,001). Analysis of Kaplan-Meier curves showed the worst survival rate in persons with HTN, taking antihypertensive drugs, but not reaching target BP levels.Conclusion. The presence of HTN significantly worsens the survival rate of men and women. Special attention of medical community should be directed to increasing the proportion of effectively treated patients with HTN.

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Contribution of hypertension and other risk factors to survival and mortality in the Russian population

Баланова¹,

Шальнова²,

Куценко

et al. 2021

Cardiovasc Ther Prev

View full text Add to dashboard Cite

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“…В связи с вышеизложенным, кардиоваскулярная профилактика, первичная и вторичная, является одним из ведущих направлений современного здравоохранения [4]. Несмотря на высокую эффективность немедикаментозной коррекции факторов риска [5][6][7], тем не менее ведущая роль медикаментозной терапии / профилактики неоспорима [8][9][10][11][12]. Более того, для ССЗ характерна комбинированная медикаментозная терапия [4,6,[8][9][10][11][12], а с учетом того, что сами они протекают чаще всего в виде коморбидности, в т.ч.…”

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Results of the pilot part of the cardiac drug overdoses hospital registry (storm): focus on drug-induced bradycardia

Yakushin

Степанович²,

Никулина

et al. 2020

I.P. Pavlov Russian Medical Biological Herald

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Aim. Analysis of the relevance of drug-induced bradycardia (DIB) as a medical and social problem, its main regularities and determination of the need for further study of this issue. Materials and Methods. The register study was performed on 01 Jan 2017-30 Jun 2018 (18 months) at the clinical base of the Ryazan Regional Clinical Cardiology Dispensary. Inclusion criteria were: 1) bradycardia/bradyarrhythmia syndrome with intake of at least one drug with a bradycardic effect (BCE), 2) signing Informed consent to the processing of personal and clinical data. No additional interventions were performed in the diagnosis or treatment of patients within the registry. Results. During 18 months, 191 patients (age 77.0 [69.0;82.0] years, 26.7% of men) were hospitalized with a verified diagnosis of DIB, which accounted for 52.6% of all cases of hospitalization for drug overdose. During the analyzed period, there was an increase in both the total number of drug overdoses (1.7 times, p0.001) and overdoses of drugs with BCE (1.8 times, p0.001). Main clinical manifestations of DIB: reduced heart rate (50 beats/min 80.0%, 40 beats/min 51.1%), sinoatrial (30.4%) and atrioventricular blocks (1st degree 8.2%, 2nd degree 10.4%, 3rd degree 14.1%), syncope (32.6%) and cardiac pauses 3 s (7.4%). Almost all (94.8%) the patients were hospitalized by ambulance, 40.7% to the intensive care unit; 17.8% required pacemaker implantation; hospital mortality was 5.2%. More than half (54.5%) of hospitalized patients took 2 drugs with BCE, 15.7% 3 and 3.14% 4 (both in monotherapy and as a part of a combination): beta-blockers 68.4%, antiarrhythmic preparations 38.9%, digoxin 25.8%, non-dihydropyridine calcium antagonists 10.5%, I1-imidazoline receptor agonist 9.5%, and other drugs with BCE 7.4%. To analyze the cause of DIB, we used clinical data of 135 patients (age 77.0 [69.0;82.0] years, 20.7% of men), who could indicate the exact dose of a taken drug with BCE. Among them, the absolute exceedance of the recommended dose of drugs with BCE was found in 14.1% of cases, while in 85.9% of cases summation/potentiation effect of several drugs with ВСЕ was observed, with intake of each in a therapeutic dose. Conclusion. The study confirmed high medical and social significance of the problem of DIB, which requires attention of practitioners, pharmacologists and clinical pharmacologists, health care providers, and also continuation of its study.

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Influence of cardiovascular risk factors on the health of rural population in Russia (review)

Bogdanova

2024

Saratov J Med Sci Res

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Objective: to assess the influence of medical and social risk factors for cardiovascular diseases on outcomes of patients living in rural and remote areas of the Russian Federation. Review writing methodology. A systematic review was carried out according to the PRISMA (The Preferred Reporting Items for Systematic reviews and Meta-Analyses) methodology using eLibrary, Google Scholar, and CyberLeninka databases. Search depth — from 2002 to 2022. The review included 19 original studies. It has been established that the prevalence of cardiovascular diseases risk factors in the rural population is not always higher than in the urban population, and the outcomes are worse. Conclusion. It has been shown that among the rural population, social determinants of health come to the fore, determining the ability of patients to follow recommendations for managing risk factors and receive timely and high-quality medical care.

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Adverse cardiovascular outcomes and their relationship with risk factors according to the prospective study MERIDIAN-RO

Cited by 6 publications

References 8 publications

Contribution of hypertension and other risk factors to survival and mortality in the Russian population

Contribution of hypertension and other risk factors to survival and mortality in the Russian population

Results of the pilot part of the cardiac drug overdoses hospital registry (storm): focus on drug-induced bradycardia

Influence of cardiovascular risk factors on the health of rural population in Russia (review)

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