Adverse Cardiovascular Effects of the Coxibs

Dogné, Jean-Michel; Supuran, Claudiu T.; Praticò, Domenico

doi:10.1002/chin.200529266

Cited by 34 publications

(42 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A less selective inhibition may lead to a more favorable balance between these opposing effects. [213] In addition to its oxygenation of arachidonic acid (5.98, Scheme 5.17), COX-2 is also responsible for oxygenation of the endocannabinoids, which exert analgesic and antiinflammatory effects at cannabinoid receptors CB1 and CB2; oxygenation of endocannabinoids turns off their painrelieving effects. Therefore, inhibition of the oxygenation of endocannabinoids should be a treatment for neuropathic pain.…”

Section: Aspirinmentioning

confidence: 99%

Enzyme Inhibition and Inactivation

Silverman

2014

The Organic Chemistry of Drug Design and Drug Action

View full text Add to dashboard Cite

Section: Aspirinmentioning

confidence: 99%

Enzyme Inhibition and Inactivation

Silverman

2014

The Organic Chemistry of Drug Design and Drug Action

View full text Add to dashboard Cite

“…Since prostaglandins are cytoprotective, long term administration of NSAID may induce gastro-intestinal ulcers, bleeding, and renal disorders due to their non-selective inhibition of both isoforms of the COX enzyme, the constitutive (COX-1) and the inducible (COX-2) isoforms [3]. On the other hand, fully selective and reversible COX-2 inhibitors with reduced gastro-intestinal toxicity have been associated with adverse cardiovascular effects [4]. Furthermore, the use of steroidal drugs as antiinflammatory agents is also becoming highly controversial due to their multiple side effects [5,6].…”

Section: Introductionmentioning

confidence: 98%

Anti-inflammatory properties of rose oxide

Nonato

Santana

Melo

et al. 2012

International Immunopharmacology

View full text Add to dashboard Cite

Rose-oxide is a fragrance found in roses and rose oil. There are no reports about the pharmacological activity of this molecule. The present study was undertaken to evaluate whether rose-oxide (RO) has anti-inflammatory properties and to investigate possible mechanisms involved with its effects. The anti-inflammatory activity of RO was first suggested by the formalin test in mice, an inflammatory pain model, because intraperitoneal (i.p.) administration of RO (50 and 100mg/kg) inhibited only the late phase of this test. To further investigate the anti-inflammatory properties of RO, the complete Freund's adjuvant (CFA)- and carrageenan-induced paw inflammation models were used. Pre-treatment with RO (50 and 100mg/kg) significantly reduced paw edema at 4, 6 and 24h after the CFA injection. In addition, RO (100mg/kg) reduced the IL-1β, but not TNF-α, local production induced by CFA. Administration of RO (25-100mg/kg) decreased the paw edema induced by carrageenan in rats, which was more evident at 3 and 4h after induction. In addition, neutrophil migration to the hind paw was measured by MPO assay after the carrageenan injection. The MPO activity was significantly inhibited by RO at 25-100mg/kg, 4h after stimulus. In another experimental set, administration of RO (25-100mg/kg) significantly reduced the leukocyte migration in the carrageenan-induced peritonitis model in mice. The results described here are the first report of pharmacological properties of RO and strongly suggest that RO possesses anti-inflammatory activity related to its ability to inhibit the IL-1β production and the leukocyte migration.

show abstract

“…As a result, a number of selective COX-II inhibitors, including Celecoxib and Rofecoxib have been introduced for clinical use with exceptional antiinflammatory properties with reduced gastric toxicity (Xie et al, 1992;Hawkey, 1999). But initial enthusiasm for selective COX-II inhibitors as safer NSAIDs has faded due to emergence of serious cardiovascular side effects on long term use and need for design and development of safer agents still remain (Dogne et al, 2005;Schnitzer, 2001).…”

Section: Introductionmentioning

confidence: 99%

Design, synthesis, and evaluation of novel indomethacin–antioxidant codrugs as gastrosparing NSAIDs

2011

View full text Add to dashboard Cite

Indomethacin has been conjugated with different antioxidants having antiulcerogenic activity with the objective of obtaining indomethacin-antioxidant codrugs as gastrosparing NSAIDs devoid of ulcerogenic side effects. Purified synthesized codrugs have been characterized by m.p., TLC, elemental analyses, FTIR, NMR, MS. The synthesized derivatives have been screened for their antiinflammatory, analgesic, and antiulcer activity. The codrugs showed retention of antiinflammatory activity with reduced ulcerogenic side effects. These results indicated that indomethacin-antioxidant codrugs have the potential to be developed as gastrosparing NSAIDs.

show abstract

Adverse Cardiovascular Effects of the Coxibs

Abstract: Organic chemistry Z 0200 Conformational Rigidity and Flexibility of the Paracyclophane Skeleton in Substituted [2.2]Paracyclophanes -[81 refs.]. -(STARIKOVA*, Z. A.; FEDYANIN, I. V.; ANTIPIN, M. Y.; Russ.

Cited by 34 publications

References 1 publication

Enzyme Inhibition and Inactivation

Enzyme Inhibition and Inactivation

Anti-inflammatory properties of rose oxide

Design, synthesis, and evaluation of novel indomethacin–antioxidant codrugs as gastrosparing NSAIDs

Contact Info

Product

Resources

About