Enzyme Inhibition and Inactivation

Silverman, Richard B.

doi:10.1016/b978-0-12-382030-3.00005-2

Cited by 5 publications

(5 citation statements)

References 278 publications

(166 reference statements)

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“…Accuracy evaluation in accordance with the ICH guidelines [5] was performed through a bias % calculus as b(%) =…”

Section: Precision Evaluationmentioning

confidence: 99%

“…The complete pathway of OA biosynthesis is reported in Figure 1. The step (5), represented in Figure 1, is directly involved in the metabolism of 5-FU because this anticancer drug is a competitive substrate of OPRTase [4]. In particular, the transferase activity of OPRTase multicomplex enzyme is inhibited by 5-FU at 59% level of control [5].…”

Section: Introductionmentioning

confidence: 99%

“…The step (5), represented in Figure 1, is directly involved in the metabolism of 5-FU because this anticancer drug is a competitive substrate of OPRTase [4]. In particular, the transferase activity of OPRTase multicomplex enzyme is inhibited by 5-FU at 59% level of control [5]. On the other hand, OPRTase is involved in a variety of metabolic disorders, such as congenital orotic aciduria.…”

Section: Introductionmentioning

confidence: 99%

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The Strange Case of Orotic Acid: The Different Expression of Pyrimidines Biosynthesis in Healthy Males and Females

Chiara,

Allegra,

Mula

et al. 2023

JPM

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Orotic acid (OA) is an intermediate metabolite of pyrimidine nucleotide biosynthesis and represents a minor diet constituent. The measurement of urinary orotic acid is useful in confirming the diagnosis of hereditary metabolic diseases. Moreover, it could be of interest to know how the physiological concentration of this metabolite changes in relation to different conditions of clinical normality. The purpose of this study was to determine the orotic acid concentration in the urine of healthy patients, to observe normal oroticuria and to evaluate if the expression of pyrimidine intermediate biosynthesis differs between healthy males and females. The orotic acid concentration in urine was performed via the ICH M10-validated analytical method. Unexpectedly, females showed a greater oroticuria than males in pediatric age (0–10); conversely, we did not find significant differences until 70 years of age. The LC-MS/MS method was suitable for use in the differential diagnosis of hereditary metabolic disease and metabolic monitoring of anticancer drug-induced toxicity. The analytical protocol was found to be rapid and ideal, and was used in the routine analysis of a clinical chemistry laboratory. The biochemical aspects related to the expression of pyrimidine biosynthesis should be further investigated in light of the obtained results.

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“…Accuracy evaluation in accordance with the ICH guidelines [5] was performed through a bias % calculus as b(%) =…”

Section: Precision Evaluationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Strange Case of Orotic Acid: The Different Expression of Pyrimidines Biosynthesis in Healthy Males and Females

Chiara,

Allegra,

Mula

et al. 2023

JPM

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“…Development of affinity labeling agents 98 led to the discovery of 1,2,3-triazole ureas (1,2,3-TUs) as potent and selective irreversible inhibitors that inactivate SHs through carbamoylation of the catalytic serine 20 , 88 , 95 , 99 – 104 ( Fig. 1 ).…”

Section: Development Of Sutex Chemistrymentioning

confidence: 99%

Development and biological applications of sulfur–triazole exchange (SuTEx) chemistry

et al. 2021

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“…It is therefore not surprising that thousands of different SA drugs, analogs and derivatives have been prepared so far. 5 However, the natural consequence of the use of these substances is their presence in the environment, where they cause serious concern, especially in soil and water. 6 In addition to directly affecting biota, including animals, they can have a major impact on microbial communities and can also lead to the development of antimicrobial resistance, with a significant impact on human health.…”

Section: ■ Introductionmentioning

confidence: 99%

Ceria-Catalyzed Hydrolytic Cleavage of Sulfonamides

Henych,

Št́astný,

Kříženecká

et al. 2024

Inorg. Chem.

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Nanoceria is a promising nanomaterial for the catalytic hydrolysis of a wide variety of substances. In this study, it was experimentally demonstrated for the first time that CeO 2 nanostructures show extraordinary reactivity toward sulfonamide drugs (sulfadimethoxine, sulfamerazine, and sulfapyridine) in aqueous solution without any illumination, activation, or pH adjustment. Hydrolytic cleavage of various bonds, including S−N, C−N, and C−S, was proposed as the main reaction mechanism and was indicated by the formation of various reaction products, namely, sulfanilic acid, sulfanilamide, and aniline, which were identified by HPLC-DAD, LC-MS/MS, and NMR spectroscopy. The kinetics and efficiency of the ceria-catalyzed hydrolytic cleavage were dependent on the structure of the sulfonamide molecule and physicochemical properties of Nanoceria prepared by three different precipitation methods. However, in general, all three ceria samples were able to cleave SA drugs tested, proving the robust and unique surface reactivity toward these compounds inherent to cerium dioxide. The demonstrated reactivity of CeO 2 to molecules containing sulfonamide or even sulfonyl (and similar) functional groups may be significant for both heterogeneous catalysis and environmentally important degradation reactions.

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Enzyme Inhibition and Inactivation

Cited by 5 publications

References 278 publications

The Strange Case of Orotic Acid: The Different Expression of Pyrimidines Biosynthesis in Healthy Males and Females

The Strange Case of Orotic Acid: The Different Expression of Pyrimidines Biosynthesis in Healthy Males and Females

Development and biological applications of sulfur–triazole exchange (SuTEx) chemistry

Ceria-Catalyzed Hydrolytic Cleavage of Sulfonamides

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