Adverse and beneficial effects of immediate treatment of Group A beta-hemolytic streptococcal pharyngitis with penicillin

Pichichero, Michael E.; Disney, Frank A.; Talpey, William B.; Green, John L.; Francis, Anne B.; Roghmann, Klaus J.; Hoekelman, Robert A.

doi:10.1097/00006454-198707000-00004

Cited by 132 publications

(60 citation statements)

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“…Five randomized controlled studies and 1 meta-analysis have examined the effect of immediate antibiotics on resolution of symptoms, 1 of which was completed since publication of the first principles of judicious use of antibiotics. [37][38][39][40][41] These studies provide strong evidence that antibiotic therapy for children with pharyngitis and confirmation of GAS shortens the duration of symptoms, including sore throat and headache, by approximately 1 day. These benefits are apparent within as few as 3 days.…”

Section: Benefitsmentioning

confidence: 79%

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Principles of Judicious Antibiotic Prescribing for Upper Respiratory Tract Infections in Pediatrics

Hersh¹,

Jackson²,

Hicks³

et al. 2013

Pediatrics

234

199

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Most upper respiratory tract infections are caused by viruses and require no antibiotics. This clinical report focuses on antibiotic prescribing strategies for bacterial upper respiratory tract infections, including acute otitis media, acute bacterial sinusitis, and streptococcal pharyngitis. The principles for judicious antibiotic prescribing that are outlined focus on applying stringent diagnostic criteria, weighing the benefits and harms of antibiotic therapy, and understanding situations when antibiotics may not be indicated. The principles can be used to amplify messages from recent clinical guidelines for local guideline development and for patient communication; they are broadly applicable to antibiotic prescribing in general.

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Section: Benefitsmentioning

confidence: 79%

“…Although data are somewhat limited, antibiotic therapy for index cases of GAS may reduce horizontal transmission and thereby prevent secondary cases. 40,42 These benefits are especially relevant in large households, child care settings, schools, and military settings.…”

Section: Benefitsmentioning

confidence: 99%

Principles of Judicious Antibiotic Prescribing for Upper Respiratory Tract Infections in Pediatrics

Hersh¹,

Jackson²,

Hicks³

et al. 2013

Pediatrics

234

199

View full text Add to dashboard Cite

show abstract

“…42,57,58,[75][76][77][78][79] Guidelines also differ with regard to the use of diagnostic tests. Those promoting outpatient tests, either a rapid antigen test or a throat culture (FR03, FI04, CA07, US08-10), recommend penicillin to treat GABHS.…”

Section: In T Er Nat Iona L Pha Ry Ngi T Is Guidel Inesmentioning

confidence: 99%

Differences Among International Pharyngitis Guidelines: Not Just Academic

Matthys¹,

Meyere²,

Driel³

et al. 2007

The Annals of Family Medicine

158

105

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PURPOSE Many countries have national guidelines for the treatment of pharyngitis. We wanted to compare the recommendations and the reported evidence in national guidelines for the management of acute sore throat in adults.METHODS Guidelines were retrieved via MEDLINE and EMBASE and through a Web-based search for guideline development organizations. The content of the recommendations and the underlying evidence were analyzed with qualitative and bibliometric methods. RESULTSWe included 4 North American and 6 European guidelines. Recommendations differ with regard to the use of a rapid antigen test and throat culture and with the indication for antibiotics. The North American, French, and Finnish guidelines consider diagnosis of group A streptococcus essential, and prevention of acute rheumatic fever remains an important reason to prescribe antibiotics. In 4 of the 6 European guidelines, acute sore throat is considered a self-limiting disease and antibiotics are not recommended. The evidence used to underpin these guidelines was different in North America and Europe. North American guidelines cited more North American references than did European guidelines (87.2% vs 48.0%; ods ratio, 4.6-11.9; P <.001).CONCLUSION Although the evidence for the management of acute sore throat is easily available, national guidelines are different with regard to the choice of evidence and the interpretation for clinical practice. Also a transparent and standardized guideline development method is lacking. These fi ndings are important in the context of appropriate antibiotic use, the problem of growing antimicrobial resistance, and costs for the community.

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“…Il n'existe au contraire aucune preuve de l'utilité prophylactique des antibiotiques pour la glomérulonéphrite aiguë. L'administration précoce d'antibiotiques est contre-productive, car elle compromet la ré-ponse immunitaire spécifique de l'organisme contre le StA et favorise de ce fait la réinfection [8,9].…”

Section: Pharyngo-amygdalite -Diagnostic Et Traitement -Antibiotiques?unclassified

Pharyngo-amygdalite - diagnostic et traitement - antibiotiques?

Bollag¹

2003

Forum Med Suisse

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Adverse and beneficial effects of immediate treatment of Group A beta-hemolytic streptococcal pharyngitis with penicillin

Cited by 132 publications

References 0 publications

Principles of Judicious Antibiotic Prescribing for Upper Respiratory Tract Infections in Pediatrics

Principles of Judicious Antibiotic Prescribing for Upper Respiratory Tract Infections in Pediatrics

Differences Among International Pharyngitis Guidelines: Not Just Academic

Pharyngo-amygdalite - diagnostic et traitement - antibiotiques?

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