Adventitial endothelial implants reduce matrix metalloproteinase-2 expression and increase luminal diameter in porcine arteriovenous grafts

Nugent, Helen M.; Sjin, Robert Tjin Tham; White, Desmond; Milton, L. G.; Manson, Roberto J.; Lawson, Jeffrey H.; Edelman, Elazer R.

doi:10.1016/j.jvs.2007.04.074

Cited by 50 publications

(46 citation statements)

References 38 publications

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“…with cholesterol-containing molecules of both lipid nuclei of soft plaques and foam cells of the intimal layer. The experiments have shown that introduction of biopolymers in the adventitial area during open or closed surgery provides the possibility to inhibit intimal thickening, inhibit restenosis, negative remodeling [9].…”

Section: Experimental Investigationsmentioning

confidence: 99%

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Morphological Reconstruction of Main Arteries by Perivascular Implantation of Sulfated Chitosan in Experimental Atherosclerosis

Кириченко¹,

Шульмин²,

Шаркова³

et al. 2017

Sovrem Tehnol Med

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The aim of the study is to demonstrate morphological reconstruction of the main arteries of rabbit hind limbs by perivascular implantation of sulfated chitosan in an atherosclerosis model.Materials and Methods. The study was performed on 24 rabbits divided into four groups of 6 animals. The rabbits in the experimental group kept on intensive cholesterol diet for 110 days were implanted 1% water-soluble sulfated chitosan gel in the perivascular fascial compartment of the saphenous artery and the femoral artery of the left hind limb. Some animals that were also kept on cholesterol diet did not undergo implantation. The group of rabbits fed with normal vivarium diet were subjected to perivascular implantation of the biopolymer, while a group of 6 rabbits also kept on normal diet served as the intact control. We estimated wall thickness of the femoral artery and the saphenous artery, their average lumen diameter, the mean lumen area of the newly formed vessels in the adventitia.Results. Daily intensive cholesterol diet for 3.5 months in rabbits leads to vivid signs of atherogenic inflammation forming in the intimal and medial layers of the main arteries of the hind limbs. Introduction of 1% water-soluble sulfated chitosan gel into the paravasal compartment of the saphenous and femoral arteries promotes formation of a large number of microvessels at the polymer resorption site increasing the specific area of new vessels. Morphological reconstruction of the main arteries is achieved through reducing the vascular wall thickness, increasing the vessel lumen and the number of para-adventitial microvessels.Conclusion. Implantation of sulfated chitosan into the perivascular compartment allows achieving the effect of therapeutic paravasal angiogenesis and inhibiting the early signs of atherogenic inflammation.Key words: atherogenic inflammation; perivascular implantation of chitosan; ischemia of the hind limbs; therapeutic angiogenesis; morphological reconstruction of the vessel wall; biodegradable polymer.

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Section: Experimental Investigationsmentioning

confidence: 99%

“…The special role in the pathogenesis of atherosclerosis is given to the adventitia [6,7]. This vessel wall component is considered to be as important as the medial layer and the intima because it takes part in regulating the proliferation of smooth muscle cells of the medial and inner vessel layers during atherogenesis [8][9][10][11].…”

mentioning

confidence: 99%

Morphological Reconstruction of Main Arteries by Perivascular Implantation of Sulfated Chitosan in Experimental Atherosclerosis

Кириченко¹,

Шульмин²,

Шаркова³

et al. 2017

Sovrem Tehnol Med

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“…The relationship is proved by a number of studies on vascular impairment modeling and minimally invasive arrangement of biopolymer particles containing allogenic endothelial cells near to a major vessel [135]. Tissue engineering in the adventitia area in open or closed surgeries in experimental models inhibit intima thickening, restenosis formation, negative remodeling [136][137][138].…”

Section: Reviewsmentioning

confidence: 99%

Pathomorphism of Limb Major Vessels in Experimental Atherogenic Inflammation. The Role of Adventitial Intimal Relations (Review)

Кириченко¹,

Patlataya²,

Шаркова³

et al. 2017

Sovrem Tehnol Med

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The review considers the problems of pathological destruction of a vascular wall at early signs of atherogenic inflammation of major arteries in hyperlipidemia in relation to modern technologies of local angioplasty. It has shown the role of molecular markers in atherogenic inflammation development and progression in intima and subintimal space. The emphasis is laid on modern genetically engineered and biopolymer technologies for vascular wall repair, the significance of adventitial and para-adventitial arterial layers in atherogenic inflammation, the formation of a therapeutic angiogenesis effect when using modern methods of adventitia bioengineering.

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“…Initial experimental studies have documented a beneficial effect of endothelial cell loaded gel-foam wraps in porcine models of AV fistula and graft stenosis [195][196][197][198] . A recent Phase II study ("V-HEALTH") was able to demonstrate technical feasibility and safety in hemodialysis patients who received a "Vascugel®" wrap loaded with treated human aortic endothelial cells at the time of AVF or AVG placement 97 .…”

Section: Endothelial Cell Loaded Gel Foam Wrapsmentioning

confidence: 99%

Hemodialysis Vascular Access Dysfunction

Lee¹

2011

Progress in Hemodialysis - From Emergent Biotechnology to Clinical Practice

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Adventitial endothelial implants reduce matrix metalloproteinase-2 expression and increase luminal diameter in porcine arteriovenous grafts

Cited by 50 publications

References 38 publications

Morphological Reconstruction of Main Arteries by Perivascular Implantation of Sulfated Chitosan in Experimental Atherosclerosis

Morphological Reconstruction of Main Arteries by Perivascular Implantation of Sulfated Chitosan in Experimental Atherosclerosis

Pathomorphism of Limb Major Vessels in Experimental Atherogenic Inflammation. The Role of Adventitial Intimal Relations (Review)

Hemodialysis Vascular Access Dysfunction

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