2007
DOI: 10.1016/j.jvs.2007.04.074
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Adventitial endothelial implants reduce matrix metalloproteinase-2 expression and increase luminal diameter in porcine arteriovenous grafts

Abstract: These results demonstrate that the adventitial application of endothelial implants significantly reduced MMP-2 expression within the venous wall, and increased venous lumen diameter and positive remodeling in a porcine arteriovenous graft model. Adventitial endothelial implants may be useful in decreasing luminal narrowing in a clinical setting.

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Cited by 50 publications
(46 citation statements)
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“…with cholesterol-containing molecules of both lipid nuclei of soft plaques and foam cells of the intimal layer. The experiments have shown that introduction of biopolymers in the adventitial area during open or closed surgery provides the possibility to inhibit intimal thickening, inhibit restenosis, negative remodeling [9].…”
Section: Experimental Investigationsmentioning
confidence: 99%
See 1 more Smart Citation
“…with cholesterol-containing molecules of both lipid nuclei of soft plaques and foam cells of the intimal layer. The experiments have shown that introduction of biopolymers in the adventitial area during open or closed surgery provides the possibility to inhibit intimal thickening, inhibit restenosis, negative remodeling [9].…”
Section: Experimental Investigationsmentioning
confidence: 99%
“…The special role in the pathogenesis of atherosclerosis is given to the adventitia [6,7]. This vessel wall component is considered to be as important as the medial layer and the intima because it takes part in regulating the proliferation of smooth muscle cells of the medial and inner vessel layers during atherogenesis [8][9][10][11].…”
mentioning
confidence: 99%
“…The relationship is proved by a number of studies on vascular impairment modeling and minimally invasive arrangement of biopolymer particles containing allogenic endothelial cells near to a major vessel [135]. Tissue engineering in the adventitia area in open or closed surgeries in experimental models inhibit intima thickening, restenosis formation, negative remodeling [136][137][138].…”
Section: Reviewsmentioning
confidence: 99%
“…Initial experimental studies have documented a beneficial effect of endothelial cell loaded gel-foam wraps in porcine models of AV fistula and graft stenosis [195][196][197][198] . A recent Phase II study ("V-HEALTH") was able to demonstrate technical feasibility and safety in hemodialysis patients who received a "Vascugel®" wrap loaded with treated human aortic endothelial cells at the time of AVF or AVG placement 97 .…”
Section: Endothelial Cell Loaded Gel Foam Wrapsmentioning
confidence: 99%