Advantame – An overview of the toxicity data

Otabe, Akira; Fujieda, Takeshi; Masuyama, Takeshi; Ubukata, Kazuyuki; Lee, C.

doi:10.1016/j.fct.2011.06.046

Cited by 30 publications

(13 citation statements)

References 10 publications

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“…Most have been approved for use as a food additive and, as such, have undergone a premarket approval process in accordance with stipulations made by Additional information regarding NNSs can be found in previously published review articles. 10,21,22,38,43,[51][52][53][54][55][56][57][58][59][60][61]…”

Section: Sweeteners and Nnssmentioning

confidence: 99%

The Use of Nonnutritive Sweeteners in Children

2019

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The prevalence of nonnutritive sweeteners (NNSs) in the food supply has increased over time. Not only are more children and adolescents consuming NNSs, but they are also consuming a larger quantity of NNSs in the absence of strong scientific evidence to refute or support the safety of these agents. This policy statement from the American Academy of Pediatrics is intended to provide the pediatric provider with a review of (1) previous steps taken for approved use of NNSs, (2) existing data regarding the safety of NNS use in the general pediatric population, (3) what is known regarding the potential benefits and/or adverse effects of NNS use in children and adolescents, (4) identified gaps in existing knowledge and potential areas of future research, and (5) suggested talking points that pediatricians may use when discussing NNS use with families This document is copyrighted and is property of the American Academy of Pediatrics and its Board of Directors. All authors have filed conflict of interest statements with the American Academy of Pediatrics. Any conflicts have been resolved through a process approved by the Board of Directors. The American Academy of Pediatrics has neither solicited nor accepted any commercial involvement in the development of the content of this publication. The guidance in this statement does not indicate an exclusive course of treatment or serve as a standard of medical care. Variations, taking into account individual circumstances, may be appropriate. All policy statements from the American Academy of Pediatrics automatically expire 5 years after publication unless reaffirmed, revised, or retired at or before that time.

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Section: Sweeteners and Nnssmentioning

confidence: 99%

The Use of Nonnutritive Sweeteners in Children

2019

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“…A JECFA 2013-ban értékelte az advantám biztonsá-gos felhasználhatóságát, amelyet számos állatkísérletes és humán vizsgálattal igazoltak [100,101]. Humán klinikai vizsgálatokban igazolták, hogy napi 0,5 mg/ttkg menynyiségig egészséges és 2-es típusú diabetesben szenvedő egyének is jól tolerálták [100,102].…”

Section: Advantám (E969)unclassified

“…Humán klinikai vizsgálatokban igazolták, hogy napi 0,5 mg/ttkg menynyiségig egészséges és 2-es típusú diabetesben szenvedő egyének is jól tolerálták [100,102]. A JECFA 0-5 mg/ ttkg/nap ADI-értéket határozott meg.…”

Section: Advantám (E969)unclassified

Az intenzív édesítőszerek biztonságossága

Lugasi

2016

Orvosi Hetilap

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Napjainkban egyre nagyobb népszerűségnek örvendenek az energiamentes édesítőszerek, amelyek a vonatkozó európai uniós jogszabály alapján kerülhetnek forgalomba, illetve lehetnek részei élelmiszereinknek. Ugyanakkor egyremásra látnak napvilágot hírek arról, hogy bizonyos mesterséges intenzív édesítőszerek, köztük is elsősorban az aszpartám, rákkeltő hatással bírnak. Az energiamentes édesítőszerek, mint valamennyi más adalékanyag, kizárólag a közösségi jogszabályokban meghatározott -kockázatbecslést követő -engedélyezés után kerülhetnek fel az engedé-lyezett anyagok listájára. Ez a lista nemcsak azon élelmiszerek körét határozza meg, amelyekben az adott anyag alkalmazható, hanem a maximálisan felhasználható mennyiséget is megadja. Az Európai Unió élelmiszerekkel kapcsolatos kockázatbecslését végző hivatala, az Európai Élelmiszerbiztonsági Hatóság (European Food Safety Authority) az újonnan elvégzett tudományos vizsgálatok tükrében rendszeres időközönként újraértékeli a már engedélyezett adalékanyagok biztonságosságát. Mind ez ideig az engedélyezett, intenzív édesítőszerek biztonságos alkalmazhatósága nem vált kétségessé. Orv. Hetil., 2016, 157(Szuppl. 1.), 14-28. Kulcsszavak: intenzív édesítőszerek, kockázatbecslés, engedélyezés, EFSA Safety of intensive sweetenersNowadays low calorie or intesive sweeteners are getting more and more popular. These sweeteners can be placed to the market and used as food additives according to the recent EU legislation. In the meantime news are coming out one after the other stating that many of these artificial intensive sweeteners can cause cancer -the highest risk has been attributed to aspartam. Low calorie sweeteners, just like all the other additives can be authorized after strickt risk assessment procedure according to the recent food law. Only after the additive has gone through these procedure can be placed to the list of food additives, which contains not only the range of food these additives can be used, but also the recommended highest amount of daily consumption. European Food Safety Authority considering the latest scientific examination results, evaluates regularly the safety of sweeteners authorized earlier. Until now there is no evidence found to question the safety of the authorized intensive sweeteners. Rövidítések ADI = (acceptable daily intake) megengedhető napi bevitel; ADME = (absorption, distribution, metabolism, excretion) abszorpció, eloszlás, metabolizmus, kiválasztás; CAP = Common Authorisation Procedure; EFSA = European Food Safety Authority; EK = Európai Közösség; EOGRTS = (extended one-generation reproductive toxicity study) kiterjesztett egygenerációs reproduktív toxicitás vizsgálat; EU = European Union; FAO = Food and Agriculture Organization; FIAP = Keywords

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“…To short or simplify the preparation process, in the present study, benzaldehyde derivatives containing hydroxyl electron‐donating groups or methoxy electron‐donating groups were selected to react with aldehyde taking place aldol reaction, the advantame intermediate was obtained from the aldol reaction, the intermediate was obtained from the aldol reaction, and then, advantame was prepared through a ring‐opening and hydrogenation reaction on the basis of the intermediate at the same time, so advantame was prepared in just two simple steps (Wu & Zheng, ). To our knowledge, a series of safety toxicology studies of advantame have been performed (Otabe, Fujieda, Masuyama, Ubukata, & Lee, ; Sclafani & Ackroff, ; Ubukata, Nakayama, & Mihara, ), and a method using HPLC and LC‐MS/MS for the determination of advantame in food was described (Kobayashi, Terada, Nakajima, ). However, currently there is barely any detailed information on the analysis or detection method of the advantame intermediate, and even the reference substance of advantame intermediate cannot be bought from the market.…”

Section: Introductionmentioning

confidence: 99%

Purification, characterization, and identification of 3‐hydroxy‐4‐methoxy benzal acrolein–an intermediate of synthesizing advantame

Chen

Qiang

Wang

et al. 2020

Food Science & Nutrition

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Advantame is a novel sweetener, and 3‐hydroxy‐4‐methoxy benzal acrolein is an important intermediate to synthesize the sweetener. The aim of this study was to evaluate a new low‐cost method to purify 3‐hydroxy‐4‐methoxy benzal acrolein, and the crude intermediate was used as raw material. The intermediate was purified using a low‐pressure column chromatography with a C18 column, using a methanol‐water (6:4, v/v) at a flow rate of 6.0 ml/min, and the loading amount of the crude intermediate in solution was 10.0 mg in total. A method for the analysis of 3‐hydroxy‐4‐methoxy benzal acrolein was established using high‐performance liquid chromatography (HPLC). This method was validated in terms of its linearity, repeatability, accuracy, detection limit, and quantitation limit. The calibration curves of 3‐hydroxy‐4‐methoxy benzal acrolein were linear (r > .999) over a wide concentration range of 0.005–0.08 mg/ml, by comparing the ratio of signal to noise, and the detection limit was 5.0 ng/ml and the quantification limit was 15.0 ng/ml. Good repeatability was obtained (RSD < 2%, n = 6), and the recoveries calculated using mixed sample previously quantified ranged from 94.5% to 106.37%. As long as, this method has been successfully applied to the analysis of 3‐hydroxy‐4‐methoxy benzal acrolein; therefore, the method can be put into practical use during the industrial synthesis and real‐time detection of the intermediate.

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Advantame – An overview of the toxicity data

Cited by 30 publications

References 10 publications

The Use of Nonnutritive Sweeteners in Children

The Use of Nonnutritive Sweeteners in Children

Az intenzív édesítőszerek biztonságossága

Purification, characterization, and identification of 3‐hydroxy‐4‐methoxy benzal acrolein–an intermediate of synthesizing advantame

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