Advantages of hyaluronic acid as a component of fibrin sheet for care of acute wound

Anilkumar, T. V.; Muhamed, Jaseer; Jose, Anumol; Jyothi, Arun; Mohanan, P.V.; Krishnan, Lissy K.

doi:10.1016/j.biologicals.2011.01.003

Cited by 73 publications

(55 citation statements)

References 23 publications

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“…Previous studies have shown the effectiveness of pneumatic devices in the treatment of acne scars [20], herpes zoster-induced depressed scars [21], and tissue necrosis following filler injection using subdermal minimal surgery technology [22]. Furthermore, these devices can be used to treat and flatten hypertrophic scars of the forehead and post-thyroidectomy scars [23,24].…”

Section: Discussionmentioning

confidence: 98%

Needle-free jet injection of hyaluronic acid improves skin remodeling in a mouse model

Kwon

Seok

Jang

et al. 2016

European Journal of Pharmaceutics and Biopharmaceutics

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Section: Discussionmentioning

confidence: 98%

Needle-free jet injection of hyaluronic acid improves skin remodeling in a mouse model

Kwon

Seok

Jang

et al. 2016

European Journal of Pharmaceutics and Biopharmaceutics

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“…The cells and elements of the extracellular matrix may modify water homeostasis within the tested sample. 28,29 The poorer hydration of PCL implants than DBC implants may be linked with the impaired GAG accumulation pattern observed in this polymer (Fig. 6).…”

Section: Discussionmentioning

confidence: 99%

Effects of electrospun scaffolds of di-O-butyrylchitin and poly-(ε-caprolactone) on wound healing

Drobnik

Krucińska

Komisarczyk

et al. 2017

CJS

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Background:We sought to determine the usefulness of electrospun dibutyrylchitin (DBC) or poly-(ε-caprolactone [PCL]), in wound treatment. We investigated the mechanisms of action of these polymers on wound healing. Methods:We synthesized DBC, a newly identified ester derivative of chitin, using a patented method comprising the substitution of butyryl groups at positions C-3 and C-6 in chitin molecules. We confirmed the double substitution by the butyric groups using infrared spectrometry. The fibrous scaffolds were obtained using the electrospinning method. A polypropylene net was implanted subcutaneously in the rat and served as a wound model. Results:Both DBC and PCL increased granulation tissue weight in the wound. In contrast to PCL, DBC did not abolish glycosaminoglycan changes in wounds. The tested samples did not impair total collagen synthesis or induce excessive fibrosis. In both PCL-and DBC-treated wounds, we observed a lower level of soluble collagen (compared with controls). The results show better hydration of the wounds in both the DBC and PCL groups. No induction of large edema formation by the tested materials was observed. These polymers induced almost identical macrophagemediated reactions to foreign-body implantation. The implants increased the blood vessel number in a wound. Conclusion:Both PCL and DBC could be used as scaffolds or dressings for wound treatment. The materials were safe and well tolerated by animals. As DBC did not disturb glycosaminoglycan accumulation in wounds and absorbed twice as much liquid as PCL, it can be considered superior.Contexte : Nous avons cherché à déterminer l'utilité du dibutyryl-chitine (DBC) ou du poly-(ε-caprolactone [PCL]) électrofilés dans le traitement des plaies. Nous avons étudié les mécanismes d'action de ces polymères sur la cicatrisation des plaies.Méthodes : Nous avons synthétisé le DBC, un dérivé ester récemment identifié de la chitine, à l'aide d'une méthode brevetée incluant la substitution des groupes butyryl aux positions C-3 et C-6 des molécules de chitine. Nous avons confirmé la substitution double par les groupes butyriques à l'aide de la spectrométrie infrarouge. Les échafaudages fibreux ont été obtenus grâce à la méthode de filage électrostatique. Un filet en polypropylène a été implanté par voie sous-cutanée dans le rat et a servi de modèle de plaie. Résultats :Le DBC et le PCL ont tous deux augmenté le poids du tissu de granulation dans la plaie. Contrairement au PCL, le DBC n'a pas supprimé les changements des glycosaminoglycanes des plaies. Les échantillons examinés n'ont pas perturbé la synthèse totale de collagène ni entraîné une fibrose excessive. Nous avons observé un niveau inférieur de collagène soluble (par rapport aux témoins) tant dans les plaies traitées par PCL que par DBC. Les résultats montrent une amélioration de l'hydratation des plaies tant pour les groupes DBC que PCL. Les matériaux à l'étude n'induisaient pas d'oedème étendu. Ces polymères ont induit des réactions macrophagiques presque identiques à l'implantation ...

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“…inflammation, granulation tissue formation, reepithelialization, and remodeling. Derivatives of hyaluronan, such as cross-linked, esterified or other chemically modified products have also been developed for tissue repair or wound healing purposes (Anilkumar et al, 2011;Chen & Abatangelo, 1999). Notably, wound healing-promoting activity of the materials is also important in the designing of materials for tissue engineering.…”

Section: 2mentioning

confidence: 99%

A review of bioactive plant polysaccharides: Biological activities, functionalization, and biomedical applications

Liu

Willför

2015

Bioactive Carbohydrates and Dietary Fibre

502

202

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Advantages of hyaluronic acid as a component of fibrin sheet for care of acute wound

Cited by 73 publications

References 23 publications

Needle-free jet injection of hyaluronic acid improves skin remodeling in a mouse model

Needle-free jet injection of hyaluronic acid improves skin remodeling in a mouse model

Effects of electrospun scaffolds of di-O-butyrylchitin and poly-(ε-caprolactone) on wound healing

A review of bioactive plant polysaccharides: Biological activities, functionalization, and biomedical applications

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