Advantages of Diffusion-Weighted Imaging Over Positron Emission Tomography-Computed Tomography in Assessment of Hilar and Mediastinal Lymph Node in Lung Cancer

Usuda, Katsuo; Sagawa, Motoyasu; Motono, Nozomu; Ueno, Masakatsu; Tanaka, Makoto; Machida, Yuichiro; Matoba, Munetaka; Kuginuki, Yasuaki; Taniguchi, Mitsuru; Ueda, Yoshimichi; Sakuma, Tsutomu

doi:10.1245/s10434-012-2799-z

Cited by 39 publications

(41 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…5 Although MRI has proven to be an invaluable tool for distinguishing RLN and cervical lymph node metastasis, 2,15,16 functional imaging, such as DWI, has been shown to facilitate diagnosis of lymph node metastasis in other malignant diseases. [17][18][19][20] Here, we evaluated the utility of DWI in differentiating metastatic from benign RLN in NPC, compared the accuracy of size-and ADC-based criteria in RLN metastasis and determined whether DWI would at all improve the diagnostic accuracy of RLN metastasis.…”

Section: Diagnosis Of Rln Metastasis With Dwimentioning

confidence: 99%

Diffusion-weighted imaging to differentiate metastatic from non-metastatic retropharyngeal lymph nodes in nasopharyngeal carcinoma

Xw²,

Zj³

et al. 2015

Dentomaxillofacial Radiology

View full text Add to dashboard Cite

Objectives: To evaluate the diagnostic value of diffusion-weighted MRI for differentiating metastatic from non-metastatic retropharyngeal lymph nodes (RLNs) in patients with nasopharyngeal carcinoma (NPC). Methods: Untreated patients with NPC (n 5 145) were scanned with both morphological MRI and diffusion-weighted imaging (DWI). RLNs (n 5 335) were classified as metastatic on the basis of response to therapy as assessed on follow-up MRI. Morphological (short-and long-axial diameters) and functional [mean apparent diffusion coefficient (ADC) and minimum ADC values] parameters of the RLNs were derived from DWI and compared between metastatic and non-metastatic groups. A receiver operating characteristic curve and the area under the curve were used to evaluate the effectiveness of individual criteria and to generate threshold values to diagnose RLN metastases. Results: Statistically significant differences between metastatic and non-metastatic RLNs were found for all four parameters derived from DWI (p , 0.001). At threshold values, accuracies of the ADC-based criteria (0.938 and 0.965 for mean and minimum ADC values, respectively) were greater than that of size-based criteria (0.838 and 0.809 for short-and longaxial diameters). The minimum ADC value at the threshold of 0.89 3 10 23 mm 2 s 21 was the most effective of all parameters in differentiating metastatic from non-metastatic RLNs with the sensitivity of 95.7%, specificity of 95.1% and accuracy of 96.5%. Conclusions: DWI is feasible for differentiating metastatic RLNs from non-metastatic nodes in patients with NPC with high accuracy, and the minimum ADC derived from DWI could serve as a standard clinical marker for disease status. Dentomaxillofacial Radiology (2015Radiology ( ) 44, 20140126. doi: 10.1259 Cite this article as: Li H, Liu X-W, Geng Z-J, Wang D-L, Xie C-M. Diffusion-weighted imaging to differentiate metastatic from non-metastatic retropharyngeal lymph nodes in nasopharyngeal carcinoma. Dentomaxillofac Radiol 2015; 44: 20140126.

show abstract

Section: Diagnosis Of Rln Metastasis With Dwimentioning

confidence: 99%

Diffusion-weighted imaging to differentiate metastatic from non-metastatic retropharyngeal lymph nodes in nasopharyngeal carcinoma

Xw²,

Zj³

et al. 2015

Dentomaxillofacial Radiology

View full text Add to dashboard Cite

show abstract

“…First, the sensitivity and accuracy of hilar and mediastinal lymph nodes by DWI were significantly higher than those of FDG-PET/CT. 28,29) Nomori et al 28) reported that the accuracy (89%) of DWI was significantly higher than that (78%) of FDG-PET/CT in 88 lung cancer cases, due to the fact that there was less overstaging cases with DWI compared with FDG-PET/CT.…”

Section: Resultsmentioning

confidence: 99%

Economic Benefits and Diagnostic Quality of Diffusion-Weighted Magnetic Resonance Imaging for Primary Lung Cancer

Usuda

Funazaki

Maeda

et al. 2017

ATCS

Self Cite

View full text Add to dashboard Cite

IntroductionThis paper focuses on the latest research of diffusion-weighted magnetic resonance imaging (DWI), and deals with economic benefits, diagnostic benefits, and prospects of DWI for lung cancer. The medical cost of a magnetic resonance imaging (MRI) is 81%-84% cheaper than that of 18-fluoro-2-deoxy-glucose positron emission tomography/computed tomography (FDG-PET/CT). DWI is reported to be useful for differential diagnosis of malignancy or benignity for neoplasm in various organs. Diagnostic efficacy by DWI for pulmonary nodules and masses and the evaluation of N factor and M factor in lung cancer are equivalent to or more than that of FDG-PET/CT. The diagnostic capability of wholebody DWI (WB-DWI) for the staging of clinically operable lung cancers is equivalent to that of FDG-PET/CT and brain MRI, and WB-DWI is now becoming a more main stream procedure. Although the diagnostic performance of DWI for lung cancer may be equivalent to that of FDG-PET/CT, prospective randomized controlled trial for comparison of diagnostic efficacy between FDG-PET/CT and DWI for lung cancer is necessary for an accurate comparison. DWI may have an advantage in the aspect of the cost and diagnostic efficacy in lung cancer management.

show abstract

“…To date, it has not been demonstrated that DWI MRI has the potential to augment diagnostic sensitivity compared to conventional MRI sequences in the identifi cation of lymph node metastases [ 51 ]. Improved diagnostic sensitivity of DWI compared to 18 F-FDG PET/CT was reported for lung [ 52 ] but not for breast cancer [ 51 ]. Sensitivity was comparable for the detection of malignant lesions with 94 % for 18 F-FDG PET/CT vs. 91 % for whole-body DWI, while specifi city was signifi cantly lower for DWI (79 %) than for [ 46 , 53 ].…”

Section: Whole-body Mrimentioning

confidence: 99%

The Radiologist’s Approach to CUP

Kazmierczak

Rominger

Cyran

2016

Cancer of Unknown Primary

View full text Add to dashboard Cite

In 2-4 % of patients with histologically proven cancer, the primary tumor cannot be localized, even by use of modern diagnostic methods. This situation is clinically described as cancer of unknown primary (CUP) [ 1 , 2 ] and has a frequency similar to pancreatic cancer, renal cell carcinoma, or leukemia [ 3 ]. Even after extensive diagnostic workup using state-of-the-art methods, less than 20 % of primary tumors are localized antemortem, compared to almost 80 % of primary tumors identifi ed in postmortem autopsy series [ 4 ].CUP tumors are adenocarcinomas in 40-60 %, undifferentiated carcinomas in 15-20 %, squamous cell carcinomas in 5-8 %, and neuroendocrine tumors in 3-5 %; 1-3 % of all CUP belong to other entities [ 5 ]. Most frequently, primary tumors are localized in the lung (20-35 %) and the pancreas (15-20 %), followed by other gastrointestinal and gynecological malignancies. Median survival in this heterogenic group of cancer patients is only 3-11 months [ 6 ]. Imaging is essential in all four steps of the diagnostic and therapeutic management of CUP patients [ 7 ]: localization of the primary tumor, identifi cation of all manifestations, identifi cation of potentially treatable tumors (i.e., breast cancer, prostate carcinoma, lymphoma, etc.), and characterization of the clinicopathological entity and stratifi cation into subsets with favorable prognosis (approximately 20 %) with differentiated and/or chemosensitive tumors for which specifi c treatment options are available and, on

show abstract

Advantages of Diffusion-Weighted Imaging Over Positron Emission Tomography-Computed Tomography in Assessment of Hilar and Mediastinal Lymph Node in Lung Cancer

Abstract: DWI has advantages over PET-CT in diagnosing malignant from benign lymph nodes of lung cancers.

Cited by 39 publications

References 28 publications

Diffusion-weighted imaging to differentiate metastatic from non-metastatic retropharyngeal lymph nodes in nasopharyngeal carcinoma

Diffusion-weighted imaging to differentiate metastatic from non-metastatic retropharyngeal lymph nodes in nasopharyngeal carcinoma

Economic Benefits and Diagnostic Quality of Diffusion-Weighted Magnetic Resonance Imaging for Primary Lung Cancer

The Radiologist’s Approach to CUP

Contact Info

Product

Resources

About