Advantages in using multifrequency excitation of contrast microbubbles for enhancing echo particle image velocimetry techniques: Initial numerical studies using rectangular and triangular waves

Zheng, Hairong; Mukdadi, Osama M.; Kim, Hyoung-Bum; Hertzberg, Jean; Shandas, Robin

doi:10.1016/j.ultrasmedbio.2004.08.018

Cited by 35 publications

(27 citation statements)

References 24 publications

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“…Moreover, SH response of the MB has shown its potential for selectively imaging bound tMBs [124,125]. The SH signal is strongly dependent on the applied acoustic pressures, the ambient pressure variations [93,[126][127][128][129][130], and the envelope of the excitation signal [131][132][133][134][135]. The SH signal is also less attenuated than the ultraharmonic and higher harmonics, and therefore a more suitable choice for high frequency applications.…”

Section: Contrast-specific Imaging Techniquesmentioning

confidence: 99%

Targeted ultrasound contrast agents for ultrasound molecular imaging and therapy

Rooij

Daeichin

Skachkov

et al. 2015

International Journal of Hyperthermia

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Ultrasound contrast agents (UCAs) are used routinely in the clinic to enhance contrast in ultrasonography. More recently, UCAs have been functionalised by conjugating ligands to their surface to target specific biomarkers of a disease or a disease process. These targeted UCAs (tUCAs) are used for a wide range of pre-clinical applications including diagnosis, monitoring of drug treatment, and therapy. In this review, recent achievements with tUCAs in the field of molecular imaging, evaluation of therapy, drug delivery, and therapeutic applications are discussed. We present the different coating materials and aspects that have to be considered when manufacturing tUCAs. Next to tUCA design and the choice of ligands for specific biomarkers, additional techniques are discussed that are applied to improve binding of the tUCAs to their target and to quantify the strength of this bond. As imaging techniques rely on the specific behaviour of tUCAs in an ultrasound field, it is crucial to understand the characteristics of both free and adhered tUCAs. To image and quantify the adhered tUCAs, the state-of-the-art techniques used for ultrasound molecular imaging and quantification are presented. This review concludes with the potential of tUCAs for drug delivery and therapeutic applications.

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Section: Contrast-specific Imaging Techniquesmentioning

confidence: 99%

Targeted ultrasound contrast agents for ultrasound molecular imaging and therapy

Rooij

Daeichin

Skachkov

et al. 2015

International Journal of Hyperthermia

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show abstract

“…Lin et al (2003) used ultrasonic imaging to measure the velocity distribution in the left ventricle of a pig. Kim et al (2004a, b); Zheng et al (2005) and Zheng et al (2006) determined flow profiles in artificial models of arteries and in a rotating flow apparatus. In contrast to optical imaging, an ultrasound image is composed by scanning the field of interest.…”

Section: Ultrasound Particle Image Velocimetrymentioning

confidence: 99%

In vivo whole-field blood velocity measurement techniques

2007

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In this article a number of whole-field blood velocity measurement techniques are concisely reviewed. We primarily focus on optical measurement techniques for in vivo applications, such as laser Doppler velocimetry (including time varying speckle), laser speckle contrast imaging and particle image velocimetry (including particle tracking). We also briefly describe nuclear magnetic resonance and ultrasound particle image velocimetry, two techniques that do not rely on optical access, but that are of importance to in vivo whole-field blood velocity measurement. Typical applications for whole-field methods are perfusion monitoring, the investigation of instantaneous blood flow patterns, the derivation of endothelial shear stress distributions from velocity fields, and the measurement of blood volume flow rates. These applications require individual treatment in terms of spatial and temporal resolution and number of measured velocity components. The requirements further differ for the investigation of macro-, meso-, and microscale blood flows. In this review we describe and classify those requirements and present techniques that satisfy them.

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“…Using terephthalic acid dosimetry, Barati et al [11] showed that, with equal energies, the combination mode of sonication generated a fluorescence intensity that was approximately 1.5 times higher than the algebraic sum of sonication at 150 kHz and 1 MHz, and 3.5 times higher than sonication at each frequency alone. Experimental results obtained from sonochemistry studies also verified that the extent of cavitation generated by multi-frequency ultrasound was higher than single-frequency irradiation [12][13][14]. The ultrasonic transducer, with a frequency in the kHz range, produces the main cavitation effects, while the other, operating in the MHz range, acts to assist in accelerating mass transfer and enhances cavitation.…”

Section: Introductionmentioning

confidence: 62%

Comparing the in vivo sonodynamic effects of dual- and single-frequency ultrasound in breast adenocarcinoma

et al. 2012

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Advantages in using multifrequency excitation of contrast microbubbles for enhancing echo particle image velocimetry techniques: Initial numerical studies using rectangular and triangular waves

Cited by 35 publications

References 24 publications

Targeted ultrasound contrast agents for ultrasound molecular imaging and therapy

Targeted ultrasound contrast agents for ultrasound molecular imaging and therapy

In vivo whole-field blood velocity measurement techniques

Comparing the in vivo sonodynamic effects of dual- and single-frequency ultrasound in breast adenocarcinoma

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