Advancing diagnostics of chronic paradontitis in children

Agarkov, N. M.; Макарян, А. С.; Гонтарева, И. С.

doi:10.15789/2220-7619-ado-1186

Cited by 1 publication

(1 citation statement)

References 6 publications

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“…Bacteria can thus enter the bloodstream and spread throughout the body, affecting organ function. It has been suggested that bacteria and their products, rather than bacteria themselves, activate the body’s monocytes/macrophages and produce a large number of inflammatory factors ( Agarkov et al, 2020 ), including endotoxin, LPS, pore proteins, and polysaccharides. In addition to this, the membrane vesicles (MVs) discovered in recent decade seem to have the similar effect.…”

Section: Introductionmentioning

confidence: 99%

Microbe-host interactions: structure and functions of Gram-negative bacterial membrane vesicles

Xiao,

Li,

Yang

2023

Front. Microbiol.

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Bacteria-host interaction is a common, relevant, and intriguing biological phenomena. The host reacts actively or passively to the bacteria themselves, their products, debris, and so on, through various defense systems containing the immune system, the bacteria communicate with the local or distal tissues of the host via their own surface antigens, secreted products, nucleic acids, etc., resulting in relationships of attack and defense, adaptation, symbiosis, and even collaboration. The significance of bacterial membrane vesicles (MVs) as a powerful vehicle for the crosstalk mechanism between the two is growing. In the recent decade, the emergence of MVs in microbial interactions and a variety of bacterial infections, with multiple adhesions to host tissues, cell invasion and evasion of host defense mechanisms, have brought MVs to the forefront of bacterial pathogenesis research. Whereas MVs are a complex combination of molecules not yet fully understood, research into its effects, targeting and pathogenic components will advance its understanding and utilization. This review will summarize structural, extraction and penetration information on several classes of MVs and emphasize the role of MVs in transport and immune response activation. Finally, the potential of MVs as a therapeutic method will be highlighted, as will future research prospects.

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Section: Introductionmentioning

confidence: 99%