Advances, problems, and complications of polypectomy

Anderloni, Andrea; Jovani, Manol; Hassan, Cesare; Repici, Alessandro

doi:10.2147/ceg.s43084

Cited by 34 publications

(20 citation statements)

References 117 publications

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“…The most common complications are perforation and hemorrhage [12,13]. Most of the serious complications have been reported to occur not during diagnostic interventions but during therapeutic procedures such as polypectomy and dilatation [14].…”

Section: Introductionmentioning

confidence: 99%

Characteristics of the Patients Undergoing Colonoscopy in a Single Center within an 8-year Period

Ãelebi¹,

Teker²,

Gürler³

et al. 2017

J Gastrointest Dig Syst

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Aim: To evaluate patient characteristics by reviewing colonoscopy procedures performed within an 8-year period in the endoscopy centre of a training and research hospital. Methods:Colonoscopy procedures that were performed for various indications between 2002 and 2009 in the endoscopy unit of our hospital were retrospectively evaluated. Of 3035 colonoscopy procedures, 2831 were included in the analysis. In addition to demographic characteristics of the patients, presence and localization of colorectal masses, presence of inflammatory bowel disease, frequency of presence of hemorrhoids, diverticula, polyps, and other diseases, as well as complications were recorded. Results:The mean age of the patients (male, 50.5%) was 54.36 ± 15.05 years (range, 16-93 years). While a pathological finding was determined in 1512 (53.4%) colonoscopy procedures, 1319 (46.6%) colonoscopy procedures were reported as normal. Concerning complications during examinations, perforation was encountered in two patients and major bleeding was not determined in any of the patients. The most common diagnoses were polyps (15.9%) and hemorrhoids (15.9%), followed by colorectal mass (12.9%), diverticula (6.8%), and inflammatory bowel disease (5.6%). Conclusion:The fact that colorectal masses ranked third among the colonoscopic diagnoses suggested that cancer screening programs should be handled nationally.

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Section: Introductionmentioning

confidence: 99%

Characteristics of the Patients Undergoing Colonoscopy in a Single Center within an 8-year Period

Ãelebi¹,

Teker²,

Gürler³

et al. 2017

J Gastrointest Dig Syst

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“…There are some disadvantages of SFP technique such as low one-bite polypectomy and complete resection rates, and increased risk of residual tissue. 4 , 10 , 12 One of the reasons might be inadequate examination of polypectomy area because of bleeding after the first bite. 4 In our study, complete resection rate was high in the SFP group when compared with the literature.…”

Section: Discussionmentioning

confidence: 99%

“… 4 , 10 , 12 One of the reasons might be inadequate examination of polypectomy area because of bleeding after the first bite. 4 In our study, complete resection rate was high in the SFP group when compared with the literature. However, it indicated that more bites were required to obtain this resection rate (Figure 2 A).…”

Section: Discussionmentioning

confidence: 99%

“…Different methods such as standard, hot, and jumbo forceps polypectomy (JFP) may be used in treatment of colon polyp ≤5 mm, named as diminutive polyps. 4 If a diminutive polyp is encountered during colonoscopy, selection of endoscopic method depends on experience and preference of the endoscopist. In a study performed among American gastroenterologists, 50.3% of participants preferred forceps polypectomy method in polyps with 1- to 3-mm size, whereas 18.5% preferred cold forceps polypectomy in polyps with 4- to 6-mm size.…”

Section: Introductionmentioning

confidence: 99%

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What Is the Most Accurate Method for the Treatment of Diminutive Colonic Polyps?

et al. 2015

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Different methods such as standard, hot, and jumbo forceps are used in endoscopic treatment of diminutive colon polyps. In the current study, it was aimed to compare efficacy and safety of standard and jumbo forceps polypectomy methods in treatment of diminutive colon polyps of ≤5 mm. Polyps with ≤5 mm which were excised during colonoscopy by using standard or jumbo forceps were evaluated. Standard and jumbo forceps polypectomy methods were randomly performed in 212 consecutive patients with diminutive colorectal polyp. One-bite polypectomy and complete resection rates were also determined among polypectomy methods. Results of 161 standard forceps polypectomy and 102 jumbo forceps polypectomy were retrospectively evaluated. Both one-bite polypectomy and complete resection rates were significantly higher in the jumbo forceps polypectomy group than the standard forceps polypectomy group (P < 0.001). In the subgroup analysis performed according to polyp sizes, complete resection rate among polyps with 3mm diameter was determined as 100%. However, numbers of bites in 4-mm and 5-mm polyps were higher in the standard forceps polypectomy group, and complete resection rate was lower than in the jumbo forceps polypectomy group (P < 0.001). Both endoscopic treatment methods may be employed in treatment of diminutive colon polyps with ≤5 mm. However, jumbo forceps polypectomy is a more effective treatment method in 4- to 5-mm polyps with high one-bite polypectomy and complete resection rate.

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“…It was reported that recurrence of advanced adenoma was associated with the size of primary polyps (>1 cm) and their location in the colon. However, the mechanism associated with polyp recurrence has not been clarified [ 13 , 14 ]. It is possible that underlying impairment could exist in normal-appearing colon mucosa in colon polyp patients; therefore, recurrent polyps may appear after complete removal of the original colon polyp.…”

Section: Introductionmentioning

confidence: 99%

Aberrant Gene Expression Profile of Unaffected Colon Mucosa from Patients with Unifocal Colon Polyp

Lian

Yang

et al. 2015

Med Sci Monit

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BackgroundThe aim of this study was to evaluate gene expression profiles in unaffected colon mucosa and polyp tissue from patients with unifocal colon polyp to investigate the potential mucosa impairment in normal-appearing colon mucosa from these patients.Material/MethodsColon polyp patients were prospectively recruited. We obtained colon biopsies from the normal-appearing sites and polyp tissue through colonoscopy. Gene expression analysis was performed using microarrays. Gene ontology and clustering were evaluated by bioinformatics.ResultsWe detected a total of 711 genes (274 up-regulated and 437 down-regulated) in polyp tissue and 256 genes (170 up-regulated and 86 down-regulated) in normal-appearing colon mucosa, with at least a 3-fold of change compared to healthy controls. Heatmapping of the gene expression showed similar gene alteration patterns between unaffected colon mucosa and polyp tissue. Gene ontology analyses confirmed the overlapped molecular functions and pathways of altered gene expression between unaffected colon mucosa and polyp tissue from patients with unifocal colon polyp. The most significantly altered genes in normal-appearing tissues in polyp patients include immune response, external side of plasma membrane, nucleus, and cellular response to zinc ion.ConclusionsSignificant gene expression alterations exist in unaffected colon mucosa from patients with unifocal colon polyp. Unaffected colon mucosa and polyp tissue share great similarity and overlapping of altered gene expression profiles, indicating the potential possibility of recurrence of colon polyps due to underlying molecular abnormalities of colon mucosa in these patients.

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Advances, problems, and complications of polypectomy

Cited by 34 publications

References 117 publications

Characteristics of the Patients Undergoing Colonoscopy in a Single Center within an 8-year Period

Characteristics of the Patients Undergoing Colonoscopy in a Single Center within an 8-year Period

What Is the Most Accurate Method for the Treatment of Diminutive Colonic Polyps?

Aberrant Gene Expression Profile of Unaffected Colon Mucosa from Patients with Unifocal Colon Polyp

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