Advances on graphene-based nanomaterials for biomedical applications

Qu, Ying; He, Feng; Yu, Chenggong; Liang, Xuewu; Dong, Liang; Ma, Long; Zhang, Qiuqiong; Lv, Jiahui; Wu, Jingde

doi:10.1016/j.msec.2018.05.018

Cited by 129 publications

(93 citation statements)

References 151 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The term graphene‐family materials refers to graphene and its derivatives, which are developed from either graphite or graphene and have similar structure and physicochemical properties to graphene. In addition to graphene, graphene oxide (GO) and reduced graphene oxide (RGO) are the most commonly used graphene‐family biomaterials (Figure ) . GO is a layered carbon‐based material fabricated through oxidation of graphite .…”

Section: Structure and Properties Of Graphene‐family Materialsmentioning

confidence: 99%

“…Its structure and physicochemical properties are between those of graphene and GO . For graphene‐family materials to meet the kinds of requirements encountered in biomedicine, there is need for further investigations of their slow biodegradation, dose‐dependent biotoxicity, and physicochemical properties, which require some improvement ,…”

Section: Structure and Properties Of Graphene‐family Materialsmentioning

confidence: 99%

“… (a) The structure of fullerene, (b) single walled carbon nanotube, (c) graphene, (d) graphene oxide, (e) carboxyl graphene oxide, and (f) reduced graphene oxide. Reproduced from ref . with permission from Elsevier.…”

Section: Structure and Properties Of Graphene‐family Materialsmentioning

confidence: 99%

See 2 more Smart Citations

Combined Application of Graphene‐Family Materials and Silk Fibroin in Biomedicine

et al. 2019

View full text Add to dashboard Cite

The main graphene‐family materials used in biomedicine include graphene, graphene oxide, and reduced graphene oxide. They have been well documented for their distinctive microstructure and excellent physicochemical properties. Although they also have some shortcomings, such as slow biodegradation and dose‐dependent biotoxicity, these problems can be solved by using them in conjunction with other biomaterials. Silk fibroin (SF), a natural polymer material with many advantageous properties, has been used widely in biomedicine. However, SF requires modification by other biomaterials to improve its mechanical properties and control its degradation rate for further use. In recent years, the combined application of graphene‐family materials and SF has increased gradually, and the effects of it on cell behavior have been preliminary investigated, such as promoting cell adhesion, proliferation, and differentiation. Further studies of the combined use have been conducted in biomedicine, including tissue engineering, biosensor, and other biomedical usage. In this paper, this combined application has been outlined and summarized, and some envisioned challenges and future perspectives have been mentioned. We hope that this review will provide some reference and inspiration for the combined application of graphene‐family materials and SF in biomedicine in the future.

show abstract

Section: Structure and Properties Of Graphene‐family Materialsmentioning

confidence: 99%

Section: Structure and Properties Of Graphene‐family Materialsmentioning

confidence: 99%

See 1 more Smart Citation

Combined Application of Graphene‐Family Materials and Silk Fibroin in Biomedicine

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Different graphene materials attract great attention of scientists and technologists all over the world. Such materials are used in electronics, adsorption, catalysis and photocatalysis, sensors, batteries, composite materials, medicine, etc [1][2][3][4][5][6].…”

Section: Extended Abstractmentioning

confidence: 99%

“…

…”

mentioning

confidence: 99%

Synthesis, Study and Applications of Graphene Materials

Gerasimova¹,

Smolsky²,

Melezhik³

et al. 2019

Proceedings of the 4th World Congress on Recent Advances in Nanotechnology

View full text Add to dashboard Cite

Extended AbstractDifferent graphene materials attract great attention of scientists and technologists all over the world. Such materials are used in electronics, adsorption, catalysis and photocatalysis, sensors, batteries, composite materials, medicine, etc [1][2][3][4][5][6].It is shown herein that the interaction of natural graphite with solutions of (NH4)2S2O8, K2S2O8, H2S2O8 or H2SO5 in sulphuric acid results in the formation of peroxosulfate graphite intercalation compounds that are able to expand at low temperature (20-60 o C). These expanded graphite intercalation compounds (EGICs) are composed of weakly bonded graphene nanoplatelets (GNPs), which can be easily exfoliated via different methods. Ultrasonic exfoliation is the most straightforward technique. Depending on sonication conditions, few-or multi-layered GNPs can be obtained (with or without using surfactants, respectively). They contain surface oxygen groups. The other way of EGIC exfoliation is through mechanical-chemical treatment.To obtain GNPs with non-oxidized surface, EGICs were processed using ammonia. Due to the highly exothermic reaction of acidic EGIC with ammonia, the energy evolved ensures further exfoliation of graphene layers with simultaneous reduction of oxygen groups. Thus, the ultrasonic treatment, which is usually the bottle-neck restricting the productivity of the process, can be excluded. In this regard, spontaneous exfoliation, induced directly by the chemical energy, is very favorable for establishing large-scale industrial production of graphene materials. Multi-layered GNPs obtained through the chemical exfoliation possess high electrical conductivity in different formulations with organic and inorganic binders. GNPs obtained through the ammonia treatment method are highly electroconductive in polymeric compositions. For instance, polymer materials containing 10-20 wt.% ammonia-GNPs possess a conductivity of 5-15 S/cm, which exceeds that of any other electroconductive carbon filler.Considering the aforementioned, methods for superficial modification of GNPs, which can allow improving their compatibility with organic polymers and the stability of their dispersions in solvents, were developed herein. The first method includes treating oxygen-containing GNPs with a phenol-formaldehyde resin (PFR); PFR-modified GNPs possess good solubility in water and epoxy resin. The second one involves the modification of GNPs using aminocumulene. High solubility (up to several wt.%) of materials obtained in water is an interesting peculiarity of these modification methods, which allows fabrication of films by drying aqueous dispersions.Moreover, graphene/ferrites nanocomposites were synthesised. For this purpose, magnetite and cobalt ferrite nanoparticles were deposited on the GNP surface from aqueous solutions of iron and cobalt salts at appropriate pH and temperature mode.The surface of GNPs can also be modified with nanoporous carbon. To perform such a synthesis, GNPs were modified with the PFR, then mixed with excess PFR, cured, carbon...

show abstract