Advances of vibrational spectroscopic methods in phytomics and bioanalysis

Huck, Christian W.

doi:10.1016/j.jpba.2013.05.010

Cited by 29 publications

(16 citation statements)

References 30 publications

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“…Spectroscopic methods applied for the authentication and quality control of herbal products mainly include vibrational spectroscopy techniques like mid-infrared and near-infrared (MIR and NIR, respectively) and Raman spectroscopy [147][148][149], as well as nuclear magnetic resonance spectroscopy (NMR) [116,150]. Usually, chemometric methods (see Section 4) are used in combination in order to extract the relevant information from the spectral data and to allow classification and discrimination of herbal samples [123].…”

Section: Spectroscopic Methodsmentioning

confidence: 99%

“…In the field of medicinal plants, these methods have been widely used for many purposes, for example, to classify herbal materials into species and geographic origins; to differentiate wild from cultivated plants; to identify adulterants; and to control the quality of herbal raw materials of intermediate products during processing, extraction, and manufacturing, and of finished herbal preparations [123,149,152]. Also, quantitative determinations are possible; however, they require instrument calibration with a large set of reference samples that have been quantitated with a reference method like HPLC, LC-MS, or GC-MS [148].…”

Section: Spectroscopic Methodsmentioning

confidence: 99%

“…Near-infrared spectroscopy employs the electromagnetic energy lying next or near to the visible energy range (i.e., 12,500-4000 cm − 1 ), while MIR molecular vibrations cover absorptions in a range between 4000 and 400 cm − 1 [148].…”

Section: Spectroscopic Methodsmentioning

confidence: 99%

“…In addition, the measurements are robust, fast, and costefficient, and the methods are highly amenable to automation and high-throughput screening and do not require the involvement of specially trained staff [152]. A promising development is the upcoming miniaturization of vibrational spectroscopy instruments into handheld devices that allow quality control in the field, e.g., directly at harvesting and collection sites [148,154,155].…”

Section: Spectroscopic Methodsmentioning

confidence: 99%

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The relevance of pharmacognosy in pharmacological research on herbal medicinal products

Pferschy‐Wenzig

Bauer

2015

Epilepsy & Behavior

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Section: Spectroscopic Methodsmentioning

confidence: 99%

Section: Spectroscopic Methodsmentioning

confidence: 99%

Section: Spectroscopic Methodsmentioning

confidence: 99%

Section: Spectroscopic Methodsmentioning

confidence: 99%

See 2 more Smart Citations

The relevance of pharmacognosy in pharmacological research on herbal medicinal products

Pferschy‐Wenzig

Bauer

2015

Epilepsy & Behavior

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“…This type of sensor offers significant advantages in terms of size, weight, robustness, spectral range, and low-cost manufacturing processes (39). Portable NIR analyzers simplify inspection and quality control processes and offer flexibility for on-site applications in the pharmaceutical industry.…”

Section: Miniaturization Of Nir Spectrometersmentioning

confidence: 99%

Near-Infrared Spectroscopy: Effective Tool for Screening of Polymorphs in Pharmaceuticals

Chadha

Haneef

2015

Applied Spectroscopy Reviews

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Near-infrared (NIR) spectroscopy has emerged as an important technique for the screening and characterization of polymorphs in pharmaceuticals. Polymorphism, the ability of a substance to exist in two or more crystalline phases having different physicochemical and biopharmaceutical parameters, has attracted pharmaceutical scientists due to the patentability of new forms. Transformation of the solid phase due to polymorphic changes during manufacturing and storage may lead to formulation hurdles. Vibrational spectroscopy, particularly NIR spectroscopy, is a widely used technique for polymorphs screening in drug development processes and has emerged as a process analytical technology tool. In this review, a brief overview of NIR spectroscopy, chemometric tools, and polymorphs screening of pharmaceuticals using NIR spectroscopy is presented. Recent developments in NIR spectroscopy instrumentation are also discussed.

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Characterization of Fritillariae cirrhosae bulbus from multiple sources by potential Q‐marker based on metabolomics and network pharmacology

Tian

Hou

Yang

et al. 2022

Rapid Comm Mass Spectrometry

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Rationale: Fritillaria cirrhosae bulbus (BFC), a typical traditional Chinese medicine with multiple botanical sources, has been used for relieving cough and reducing sputum. Studies have shown that there were obvious differences in the chemical compositions and clinical efficacy of different sources of BFC. How to characterise BFC from botanical sources accurately and quickly is vital for drug quality evaluation and clinical applications.Methods: In the present study, an integrated strategy of plant metabolomics combined with the target network pharmacology was developed to characterise BFC. Plant metabolomics analysis was performed to screen out the chemical markers of six species of BFC. Then, target network pharmacology was applied to explore the relationship between chemical markers and related diseases. Finally, potential Q-markers for species characterization were selected by combined analysis of plant metabolomics and the target network pharmacology.Results: A total of 67 Fritillaria alkaloid compounds were identified. Six species showed clear characterization by multivariate statistical analysis, resulting in 12 chemical markers. Meanwhile, a total of nine components related to asthma were screened out based on the target network pharmacology. Taking content difference and pharmacological activity into consideration, nine constituents were selected as potential Q-markers. Conclusion:The method developed provided not only a standard protocol for characterising different species of BFC directly, but also an effective approach for multisource medicines discrimination. | INTRODUCTIONFritillaria cirrhosae bulbus (BFC) is a perennial herbaceous plant in the Liliaceae family and recorded in the Chinese Pharmacopoeia. It has the effects of clearing heat and moistening the lungs, eliminating phlegm and relieving asthma. 1,2 BFC is a typical traditional Chinese medicine (TCM) with multiple botanical sources including FritiLlaria cirrhosa D. Don (F. cirrhosa), FritiLlaria unibracteata Hsiao et K.C.Hsia (F. unibracteata), Fritillaria przewalkii Maxim. (F. przewalskii), Fritillaria delavayi Franch (F. delavayi), Fritillaria taipaiensis P.Y.Li (F. taipaiensis), Abbreviations: BFC, Fritillariae cirrhosae bulbus; cAMP, cyclic adenosine monophosphate; CES, cigarette smoke extract; cps, counts per second; CS, cigarette smoke; FAs, Fritillaria alkaloids; IDA, information dependent acquisition; OMIM, Online Mendelian Inheritance in Men; PCA, principal component analysis; PLS-DA, partial least squared discriminant analysis; PPI, protein-protein interaction; TCM, traditional Chinese medicine; UPLC-QTOF-MS/MS, UPLC-hybrid triple quadrupole time of flight-MS/MS; VIP, variable importance in projection.Xi Tian and Jiali Hou contributed equally to this work.

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Advances of vibrational spectroscopic methods in phytomics and bioanalysis

Cited by 29 publications

References 30 publications

The relevance of pharmacognosy in pharmacological research on herbal medicinal products

The relevance of pharmacognosy in pharmacological research on herbal medicinal products

Near-Infrared Spectroscopy: Effective Tool for Screening of Polymorphs in Pharmaceuticals

Characterization of Fritillariae cirrhosae bulbus from multiple sources by potential Q‐marker based on metabolomics and network pharmacology

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