1998
DOI: 10.1159/000044930
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Advances in the Understanding of the Nephrotoxicity of Radiocontrast Media

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Cited by 18 publications
(14 citation statements)
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References 40 publications
(52 reference statements)
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“…30 Furthermore, the mechanisms responsible for reduction in renal perfusion involve tubular and vascular events. 31,32 On the other hand, contrast medium produces marked natriuresis and diuresis, which can activate the tubuloglomerular feedback response, 33 leading to vasoconstriction of the glomerular afferent arterioles and causing a decrease in GFR. The present study results suggest that the pre-existing decreasing GFR and its further reduction after administration of contrast might be the factor most involved in the development of CIN.…”
Section: Discussionmentioning
confidence: 99%
“…30 Furthermore, the mechanisms responsible for reduction in renal perfusion involve tubular and vascular events. 31,32 On the other hand, contrast medium produces marked natriuresis and diuresis, which can activate the tubuloglomerular feedback response, 33 leading to vasoconstriction of the glomerular afferent arterioles and causing a decrease in GFR. The present study results suggest that the pre-existing decreasing GFR and its further reduction after administration of contrast might be the factor most involved in the development of CIN.…”
Section: Discussionmentioning
confidence: 99%
“…The mechanisms responsible for reduction in renal perfusion involve activation of the tubulo-glomerular feedback response and the release of endogenous vasoactive mediators such as endothelin and adenosine. A reduction in the intra-renal production of the vasodilators nitric oxide and prostacyclin may also contribute to the pathogenesis of CMN [24,38].…”
Section: Pathophysiologymentioning
confidence: 99%
“…They are characterized by the proximal epithelial cell's vacuolization, interstitial inflammation and increase of enzymuria after using this agent. These alterations disappear in a few days (9) .…”
Section: Discussionmentioning
confidence: 92%
“…Studies demonstrate that the hydration regime using saline isotonic solution and hypotonic serum (sodium chloride 0.45% plus glucose 5%) 12 hours before, and after the ICM use, is more effective that hydration with physiologic solution in 0.9% (1,(4)(5)(6)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) . Regarding medicines, some studies shown the use of acetylcysteine (antioxidant) associated to hydration as an attenuating therapy against acute renal failure in risk patients (21) .…”
Section: Preventionmentioning
confidence: 99%