Advances in the Development of Antiviral Compounds for Rotavirus Infections

Tohmé, María Julieta; Delgui, Laura Ruth

doi:10.1128/mbio.00111-21

Cited by 13 publications

(10 citation statements)

References 140 publications

(145 reference statements)

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“…There are more than 685 million cases of acute viral gastroenteritis reported annually [ 74 ]. Viral gastroenteritis (GE), also called “stomach flu”, results in up to 200,000 deaths of children each year, which is one of the highest pediatric mortality rates worldwide [ 75 , 76 ]. Enteric adenoviruses (eAdVs), rotaviruses (RV), astroviruses (HAtVs), and sapoviruses (SaV) are a leading cause of acute GE, along with noroviruses (NoV) [ 74 , 77 , 78 ].…”

Section: Gastroenteric Infectionsmentioning

confidence: 99%

“…The GE therapy research is limited, as there are some difficulties with growing certain viruses and/or specific strains [ 85 ]. There are not so many new antivirals and treatments found, as more attention has been on repurposing drugs [ 86 ], such as nitazoxanide [ 87 , 88 , 89 , 90 , 91 ], rupintrivir, and citrate among others [ 76 , 85 , 92 , 93 , 94 ]. However, none of the potential treatments has been introduced as accepted therapy [ 76 ].…”

Section: Gastroenteric Infectionsmentioning

confidence: 99%

“…There are not so many new antivirals and treatments found, as more attention has been on repurposing drugs [86], such as nitazoxanide [87][88][89][90][91], rupintrivir, and citrate among others [76,85,[92][93][94]. However, none of the potential treatments has been introduced as accepted therapy [76].…”

Section: Gastroenteric Infectionsmentioning

confidence: 99%

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Aspects of Antiviral Strategies Based on Different Phototherapy Approaches: Hit by the Light

et al. 2022

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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which caused the COVID-19 pandemic spreading around the world from late 2019, served as a ruthless reminder of the threat viruses pose to global public health. The synthesis of new antiviral drugs, as well as repurposing existing products, is a long-term ongoing process which has challenged the scientific community. One solution could be an effective, accessible, and rapidly available antiviral treatment based on phototherapy (PT). PT has been used to treat several diseases, and relies on the absorption of light by endogenous molecules or exogenous photosensitizers (PS). PT has often been used in cancer treatment and prophylaxis, and as a complement to established chemotherapy and immunotherapy in combined therapeutic strategy. Besides significant applications in anticancer treatment, studies have demonstrated the beneficial impact of PT on respiratory, systemic, emerging, and oncogenic viral infections. The aim of this review was to highlight the potential of PT to combat viral infections by summarizing current progress in photodynamic, photothermal, and photoacoustic approaches. Attention is drawn to the virucidal effect of PT on systemic viruses such as the human immunodeficiency virus and human herpes viruses, including the causative agent of Kaposi sarcoma, human herpes virus (HHV8). PT has good potential for disinfection in anti-norovirus research and against pandemic viruses like SARS-CoV-2.

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Section: Gastroenteric Infectionsmentioning

confidence: 99%

Section: Gastroenteric Infectionsmentioning

confidence: 99%

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Aspects of Antiviral Strategies Based on Different Phototherapy Approaches: Hit by the Light

et al. 2022

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“…Further antiviral compounds targeting other RV components—e.g., gemcitabine [ 102 ] and 6-thioguanine [ 103 ]—have been reviewed elsewhere [ 97 , 104 ]. Due to limited in vitro results, more research is necessary to characterize their antiviral action.…”

Section: Antiviral Targets and Known Antiviralsmentioning

confidence: 99%

Current and Future Antiviral Strategies to Tackle Gastrointestinal Viral Infections

et al. 2021

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Acute gastroenteritis caused by virus has a major impact on public health worldwide in terms of morbidity, mortality, and economic burden. The main culprits are rotaviruses, noroviruses, sapoviruses, astroviruses, and enteric adenoviruses. Currently, there are no antiviral drugs available for the prevention or treatment of viral gastroenteritis. Here, we describe the antivirals that were identified as having in vitro and/or in vivo activity against these viruses, originating from in silico design or library screening, natural sources or being repurposed drugs. We also highlight recent advances in model systems available for this (hard to cultivate) group of viruses, such as organoid technologies, and that will facilitate antiviral studies as well as fill some of current knowledge gaps that hamper the development of highly efficient therapies against gastroenteric viruses.

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“…A positive impact of RV vaccination has been demonstrated, but the incidence and mortality rate of RV-induced AGE in high- and low-income countries remain to be different from each other. This scenario strongly suggests the necessity of anti-RV strategies to limit the number of deaths deriving from dehydration 5 .…”

Section: Introductionmentioning

confidence: 99%

Protective effects of the postbiotic deriving from cow’s milk fermentation with L. paracasei CBA L74 against Rotavirus infection in human enterocytes

Bruno

Paparo

Pisapia

et al. 2022

Sci Rep

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Rotavirus (RV) is the leading cause of acute gastroenteritis-associated mortality in early childhood. Emerging clinical evidence suggest the efficacy of the postbiotic approach based on cow’s milk fermentation with the probiotic Lacticaseibacillus paracasei CBAL74 (FM-CBAL74) in preventing pediatric acute gastroenteritis, but the mechanisms of action are still poorly characterized. We evaluated the protective action of FM-CBAL74 in an in vitro model of RV infection in human enterocytes. The number of infected cells together with the relevant aspects of RV infection were assessed: epithelial barrier damage (tight-junction proteins and transepithelial electrical resistance evaluation), and inflammation (reactive oxygen species, pro-inflammatory cytokines IL-6, IL-8 and TNF-α, and mitogen-activated protein kinase pathway activation). Pre-incubation with FM-CBA L74 resulted in an inhibition of epithelial barrier damage and inflammation mediated by mitogen-activated protein kinase pathway activation induced by RV infection. Modulating several protective mechanisms, the postbiotic FM-CBAL74 exerted a preventive action against RV infection. This approach could be a disrupting nutritional strategy against one of the most common killers for the pediatric age.

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Advances in the Development of Antiviral Compounds for Rotavirus Infections

Cited by 13 publications

References 140 publications

Aspects of Antiviral Strategies Based on Different Phototherapy Approaches: Hit by the Light

Aspects of Antiviral Strategies Based on Different Phototherapy Approaches: Hit by the Light

Current and Future Antiviral Strategies to Tackle Gastrointestinal Viral Infections

Protective effects of the postbiotic deriving from cow’s milk fermentation with L. paracasei CBA L74 against Rotavirus infection in human enterocytes

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