Advances in Technical Assessment of Spiral Inertial Microfluidic Devices Toward Bioparticle Separation and Profiling: A Critical Review

Bagi, Mahsa; Amjad, Fatemeh; Ghoreishian, Seyed Majid; Sohrabi Shahsavari, Somayeh; Huh, Yun Suk; Moraveji, Mostafa Keshavarz; Shimpalee, Sirivatch

doi:10.1007/s13206-023-00131-1

Cited by 24 publications

(9 citation statements)

References 165 publications

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“…Hypoxia, induced by reduced oxidative phosphorylation, enhances free radical production in mitochondria ( 32 ). Reactive oxygen species can trigger renal cell apoptosis through stress kinase activation and intrinsic pathways involving c-Jun N-terminal kinases, p38 MAPK, and caspases ( 33 , 34 ). The potential bicarbonate mechanism for preventing CIN consists in inhibiting the generation of free oxygen radicals in an acidic medium induced by contrast media, preventing renal injury.…”

Section: Discussionmentioning

confidence: 99%

Prospective Randomized Trial of Na/K Citrate for the Prevention of Contrast-Induced Nephropathy in High-risk Patients

Iranirad,

Sadeghi,

Hejazi

2024

MJIRI

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Background Contrast-induced nephropathy (CIN) or contrast-induced acute kidney injury (CI-AKI) refers to an acute kidney injury (AKI) occurring after exposure to contrast media, commonly used in diagnostic procedures or therapeutic angiographic interventions. Recently, Na/K citrate, used for urine alkalinization, has been assessed for preventing CIN. This experiment evaluated Na/K citrate’s efficacy in preventing CIN in high-risk patients undergoing cardiac catheterization. Methods A prospective randomized clinical trial involved 400 patients with moderate- to high-risk factors for CIN undergoing elective percutaneous coronary intervention (PCI). They were randomly assigned to either the control or Na/K citrate groups. The Na/K citrate group (n = 200) received a 5 g Na/K citrate solution diluted in 200 mL water 2 hours before and 4 hours after the first administration, along with intravenous hydration for 2 hours before and 6 hours after the procedure. In contrast, the control group (n = 200) received only intravenous hydration. Serum creatinine (SCr) levels were measured before contrast exposure and 48 hours afterward. CIN was defined as a 25% increase in serum creatinine (SCr) or > 0.5 mg/dL 48 hours after contrast administration. The significance level was set at P ˂ 0.05. Results CIN was observed in 33 patients (16.5%) in the control group and 6 patients (3%) in the Na/K citrate group. The incidence of CIN was found to have a significant difference between the 2 groups 48 hours after receiving the radiocontrast agent (P < 0.001). Conclusion Our results show that Na/K citrate is helpful and substantially reduces the incidence of CIN.

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Section: Discussionmentioning

confidence: 99%

Prospective Randomized Trial of Na/K Citrate for the Prevention of Contrast-Induced Nephropathy in High-risk Patients

Iranirad,

Sadeghi,

Hejazi

2024

MJIRI

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“…There are thesis that NAC can be used as the first line of smoking cessation treatment because it is very effective on systemic inflammation and reduces symptoms of withdrawal syndrome (15,16). McKetin et al concluded that NAC can be effective in the treatment of addiction to methamphetamines due to its antioxidant effects and ability to balance brain glutamate systems but reports emphasize the dual role of ROS in cancer development and progression.…”

Section: Discussionmentioning

confidence: 99%

“…N-acetylcysteine is a thiol-containing compound that acts as a precursor of reduced glutathione by providing thiol groups. This compound directly removes reactive oxygen species and finally creates a state of balance between oxidation and reduction in cells (15,16).…”

Section: Introductionmentioning

confidence: 99%

The Effect of N-acetylcysteine on Alprazolam Withdrawal Symptoms in Wistar Male Albino Rats

Marvast,

Amnieh,

Navabazam

et al. 2024

CJMS

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Introduction: Alprazolam is a benzodiazepine drug that is mainly used to treat generalized anxiety disorder and sleep disorders. Doctors' insistence on prescribing alprazolam due to its long half-life (16 hours) can lead to severe withdrawal complications. The aim of this study was to evaluate the effect of N-acetylcysteine (NAC) as an antioxidant drug on reducing the withdrawal symptoms of alprazolam in male albino rats. Material and Methods: In this experimental study, 50 albino male Wistar rats were used. 10 rats received normal saline by gavage for 26 days (sham), the rest of the rats received 1 mg / kg of alprazolam daily for 21 days and after drug dependence were randomly divided into 4 groups were divided. The negative control group received normal saline by gavage daily for up to 4 days after the dependence period. The treated groups also received 100, 200, and 400 mg / kg NAC orally for 4 days after the dependence period, after which the anti-anxiety and restless effects of N-acetylcysteine were assessed by behavioral test (Elevated plus-maze test). Results: The variables OAE (p = 0.18), CAE (p = 0.88), CAT (p = 0.53) and OAT percent (p = 0.29) did not show a significant difference between the 5 treatment groups; But OAT (p = 0.07) and OAE_percent (p = 0.001) showed a significant difference between the 5 treatment groups (p <0.05). Conclusion: Due to the antioxidant properties of NAC and its ability to counteract oxidative stress in the nervous system, it can be used to control the symptoms of withdrawal syndrome in people with a history of alprazolam dependence. In the present study, a dose of 400 mg / kg NAC had the best therapeutic effects in rats. In future studies, it is recommended to obtain an appropriate dose for people who experience symptoms of alprazolam withdrawal syndrome.

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“…The semiconductor based heterogeneous photocatalytic reaction has the best application in water purification [15]. Nowadays, nanotechnology and related materials were applied in different fields including fuel cell, medicine, catalysis, separation, removal and etc [16][17][18][19][20]. The ZnO is extensively utilized as a photocatalyst among other metal oxide based semiconducting materials such as WO 3 and TiO 2 and others [21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Rapidly chemical preparation of Mn doped ZnO nanostructures for photocatalysis efficiency based on UV light system and mechanism insights

Fatolahi,

Janani

2024

Phys. Scr.

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Through a facile chemical precipitation process, pure zinc oxide (ZnO) and various ratio of Mn-doped zinc oxide (Zn1-xMnxO) nanostructured materials were synthesized. The degradation of an azo dye acid orange 2 (AO-2) solution under UV light was investigated using the synthesized materials as photocatalysts. XRD, FTIR, DLS, FESEM, EDS, PL, BET, magnetic, TGA and UV-vis techniques were used to elucidate the structural, functional, particle, elemental, morphological, and optical aspects of the catalysts. The XRD and FESEM analysis showed the hexagonal ZnO structure and spherical shape of the ZnO nano-photocatalyst, respectively. Under UV irradiation for 60 minutes, MZ-25 NPs demonstrated better degradation (100.0%) of AO-2 dye. The effect of various factors such as catalyst quantity, and pH of the dye solution on the rate removal was investigated. After 60 minutes of UV light irradiation, dye removal was obtained under ideal conditions (with catalyst loading of 3 mgL-1, and pH 4).

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Advances in Technical Assessment of Spiral Inertial Microfluidic Devices Toward Bioparticle Separation and Profiling: A Critical Review

Cited by 24 publications

References 165 publications

Prospective Randomized Trial of Na/K Citrate for the Prevention of Contrast-Induced Nephropathy in High-risk Patients

Prospective Randomized Trial of Na/K Citrate for the Prevention of Contrast-Induced Nephropathy in High-risk Patients

The Effect of N-acetylcysteine on Alprazolam Withdrawal Symptoms in Wistar Male Albino Rats

Rapidly chemical preparation of Mn doped ZnO nanostructures for photocatalysis efficiency based on UV light system and mechanism insights

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