Advances in surface-enhanced Raman spectroscopy for analysis of pharmaceuticals: A review

Alula, Melisew Tadele; Mengesha, Zebasil Tassew; Mwenesongole, Ellen

doi:10.1016/j.vibspec.2018.06.013

Cited by 78 publications

(30 citation statements)

References 84 publications

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“…Elastic scattering produces light with the same frequency and wavelength as the incident light, while inelastic scattering generates light with multiple wavelengths and frequencies [99]. Most of the light that is scattered is elastic, and about one in every million scattered photons takes part in inelastic scattering [48,100]. The Raman schematic in Figure 7 illustrates how the dichroic mirror and filter selectively suppresses the light scattered from the sample and eliminates a portion of the elastically scattered light (here Rayleigh light) prior to reaching the detector.…”

Section: Raman Spectroscopymentioning

confidence: 99%

“…The intensity of the background fluorescence signal is equal to or larger than the Raman signal [16]. A reduction in the protein fluorescence signal is possible by using a longer wavelength (red or lower end of near-infrared) as the light source [100,109].…”

Section: Fluorescence Signal Due To Presence Of Proteinmentioning

confidence: 99%

“…SERS, developed in the mid-1970s, is due to a localized surface plasmon generated by an electromagnetic resonant effect between a substrate and an excitation light source across the low concentration analyte. This effect generates an increase in signal by 11 orders of magnitude [100,110]. Metal (ex.…”

Section: Inherently Weak Raman Signalsmentioning

confidence: 99%

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Review of Non-Invasive Glucose Sensing Techniques: Optical, Electrical and Breath Acetone

Shokrekhodaei

Quinones

2020

Sensors

146

109

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Annual deaths in the U.S. attributed to diabetes are expected to increase from 280,210 in 2015 to 385,840 in 2030. The increase in the number of people affected by diabetes has made it one of the major public health challenges around the world. Better management of diabetes has the potential to decrease yearly medical costs and deaths associated with the disease. Non-invasive methods are in high demand to take the place of the traditional finger prick method as they can facilitate continuous glucose monitoring. Research groups have been trying for decades to develop functional commercial non-invasive glucose measurement devices. The challenges associated with non-invasive glucose monitoring are the many factors that contribute to inaccurate readings. We identify and address the experimental and physiological challenges and provide recommendations to pave the way for a systematic pathway to a solution. We have reviewed and categorized non-invasive glucose measurement methods based on: (1) the intrinsic properties of glucose, (2) blood/tissue properties and (3) breath acetone analysis. This approach highlights potential critical commonalities among the challenges that act as barriers to future progress. The focus here is on the pertinent physiological aspects, remaining challenges, recent advancements and the sensors that have reached acceptable clinical accuracy.

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Section: Raman Spectroscopymentioning

confidence: 99%

Section: Fluorescence Signal Due To Presence Of Proteinmentioning

confidence: 99%

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Review of Non-Invasive Glucose Sensing Techniques: Optical, Electrical and Breath Acetone

Shokrekhodaei

Quinones

2020

Sensors

146

109

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“…The spectra showed good quality, with a root mean square error of cross validation (RMSECV) between 5% and 7% and a high correlation coefficient ( r > .98) for cocaine determination by PLS, obtained in both spectroscopy methods. The use of surface‐enhanced Raman spectroscopy (SERS) in various analysis related to the study of pharmaceutical systems was also reported . In these studies, the increase of signal intensity favors the use of Raman spectroscopy for quantitative purposes for several formulations.…”

Section: Introductionmentioning

confidence: 99%

“…The use of surface-enhanced Raman spectroscopy (SERS) in various analysis related to the study of pharmaceutical systems was also reported. [19] In these studies, the increase of signal intensity favors the use of Raman spectroscopy for quantitative purposes for several formulations. For example, Mamián-López and Poppi [15] used a combination of SERS to obtain Raman hyperspectral images of polymeric microfilms loaded with paracetamol.…”

Section: Introductionmentioning

confidence: 99%

Raman microimaging as an analytical technique for simultaneous quantification and localization of active principles in pharmaceutical solid dosage forms

Sanhueza

Meléndrez

Plessing

et al. 2020

J Raman Spectroscopy

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Raman microimaging, as a product of Raman microspectroscopy mapping and multivariate analysis, was used for the localization and quantification of active pharmaceutical ingredients (APIs) in tablets made in laboratory. This was done to develop an analytical strategy to simultaneously recover qualitative and quantitative information of solid dosage forms at a microscopic level by using a nondestructive method. A chemical system, composed of acetaminophen (AMP), caffeine, and one excipient (microcrystalline cellulose), was subjected to chemometric analysis through principal component analysis (PCA) and multivariate curve resolution with alternating least squares (MCR–ALS). This was done by using Raman spectra obtained from microscopic images with pixel sizes of 15 × 15 μm to localize the APIs in the tablets. Partial least squares (PLS) was applied as a calibration method to obtain bulk and single‐pixel concentrations of APIs in the samples. MCR–ALS provided better results than PCA for the localization of APIs. PLS achieved satisfactory root mean standard error values in the external validation set (<4% w/w) in bulk concentration determinations of AMP. This method also achieved concentrations for each pixel of the images, reconstructing images very similar to those obtained by MCR–ALS. Consequently, simultaneous localization and quantification of AMP was possible. Finally, the performance of Raman microimaging was evaluated through estimation of analytical figures of merit (AFOMs) of the technique used to assess the quantification of APIs. This included different calculus of uncertainty in the signal in a technique where the signal/noise ratio is low, and AFOMs for multivariate quantification are not often reported.

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Library and Method Development for Portable Instrumentation

Schreyer¹

2021

Portable Spectroscopy and Spectrometry

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Advances in surface-enhanced Raman spectroscopy for analysis of pharmaceuticals: A review

Cited by 78 publications

References 84 publications

Review of Non-Invasive Glucose Sensing Techniques: Optical, Electrical and Breath Acetone

Review of Non-Invasive Glucose Sensing Techniques: Optical, Electrical and Breath Acetone

Raman microimaging as an analytical technique for simultaneous quantification and localization of active principles in pharmaceutical solid dosage forms

Library and Method Development for Portable Instrumentation

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