Advances in Stroke 2009

Hegele, Robert A.; Dichgans, Martin

doi:10.1161/strokeaha.109.571034

Cited by 8 publications

(1 citation statement)

References 26 publications

(50 reference statements)

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“…Genetic variants that co-occur with ischemic stroke serve as genetic markers to characterize the inheritance of genetic material across generations within affected individuals within a family. By comparing the pattern of inheritance of these genetic markers with the pattern of disease transmission within families, researchers calculate linkage scores to estimate the connection between a genetic variant and ischemic stroke [41,42]. Subsequently, the region or locus of interest can be subjected to further sequencing to identify specific genetic causes of the disease.…”

Section: Linkage Analysismentioning

confidence: 99%

Genetics in Ischemic Stroke: Current Perspectives and Future Directions

Zhang,

Loong,

Yuen

et al. 2023

JCDD

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Ischemic stroke is a heterogeneous condition influenced by a combination of genetic and environmental factors. Recent advancements have explored genetics in relation to various aspects of ischemic stroke, including the alteration of individual stroke occurrence risk, modulation of treatment response, and effectiveness of post-stroke functional recovery. This article aims to review the recent findings from genetic studies related to various clinical and molecular aspects of ischemic stroke. The potential clinical applications of these genetic insights in stratifying stroke risk, guiding personalized therapy, and identifying new therapeutic targets are discussed herein.

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Section: Linkage Analysismentioning

confidence: 99%