Advances in PET imaging of cancer

Schwenck, Johannes; Sonanini, Dominik; Cotton, Jonathan; Rammensee, Hans‐Georg; Fougère, Christian la; Zender, Lars; Pichler, Bernd J.

doi:10.1038/s41568-023-00576-4

Cited by 40 publications

(29 citation statements)

References 247 publications

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“…Quantitative pre-and post-therapy imaging plays a major role in nuclear medicine theranostics. Different imaging modalities such as SPECT or PET are used depending on the radiotracer under investigation [19,20,21,22,23,24]. High image quality to enable precise tumor and organ segmentation and a high quantitative accuracy to access activity concentrations are indispensable to enable subsequent dosimetry calculations.…”

Section: General Workflow For Image Derived Dosimetrymentioning

confidence: 99%

On the Use of Artificial Intelligence for Dosimetry of Radiopharmaceutical Therapies

Brosch-Lenz,

Delker,

Schmidt

et al. 2023

Nuklearmedizin

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Routine clinical dosimetry along with radiopharmaceutical therapies is key for future treatment personalization. However, dosimetry is considered complex and time-consuming with various challenges amongst the required steps within the dosimetry workflow. The general workflow for image-based dosimetry consists of quantitative imaging, the segmentation of organs and tumors, fitting of the time-activity-curves, and the conversion to absorbed dose. This work reviews the potential and advantages of the use of artificial intelligence to improve speed and accuracy of every single step of the dosimetry workflow.

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Section: General Workflow For Image Derived Dosimetrymentioning

confidence: 99%

On the Use of Artificial Intelligence for Dosimetry of Radiopharmaceutical Therapies

Brosch-Lenz,

Delker,

Schmidt

et al. 2023

Nuklearmedizin

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Section: Figurementioning

confidence: 99%

“…Multimodality imaging that harnesses the strengths of different imaging techniques promises improved accuracy in both diagnosis and therapeutic assessment of malignant tumors. [1][2][3][4][5][6][7] Dual-modal fluorescence and magnetic resonance (MR) imaging, by integrating the high sensitivity of fluorescence imaging with the exceptional spatial resolution of MR imaging, enables the visualization of low concentrations of tumor biomarkers and facilitates accurate localization and assessment of tumor size, shape, and surrounding tissue structures. [8][9][10][11] Bimodal probes can be readily constructed by conjugating fluorescent moieties with MR imaging contrast agents; [12] however, conventional conjugates typically provide a constant signal irrespective of their distribution within the body.…”

mentioning

confidence: 99%

AIEgens Cross‐linked Iron Oxide Nanoparticles Synchronously Amplify Bimodal Imaging Signals in Situ by Tumor Acidity‐Mediated Click Reaction

Dong,

Liu,

et al. 2023

Angew Chem Int Ed

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Activatable dual‐modal molecular imaging probes present a promising tool for the diagnosis of malignant tumors. However, synchronously enhancing dual‐modal imaging signals under a single stimulus is challenging. Herein, we propose an activatable bimodal probe that integrates aggregation‐induced emission luminogens (AIEgens) and iron oxide nanoparticles (IOs) to synergistically enhance near‐infrared fluorescence (NIRF) intensity and magnetic resonance (MR) contrast through a tumor acidity‐mediated click reaction. Tumor acidity‐responsive IOs containing dibenzocyclooctyne groups (termed cDIOs) and AIEgens containing azide groups (termed AATs) can be covalently cross‐linked in response to tumor acidity, which leads to a simultaneous enhancement in NIRF intensity (~12.4‐fold) and r2 relaxivity (~2.8‐fold). cDIOs and AATs were effective activated in mice orthotropic breast tumor, and the cross‐linking prolonged their retention in tumor, further augmenting the bimodal signals and expanding imaging time frame. This facile strategy leverages the inherent properties of probes themselves and demonstrates promise in future translational studies.

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“…[17,18] Techniques, such as positron emission tomography (PET) and single-photon emission computed tomography (SPECT), leverage these isotopes for non-invasive quantitative imaging, providing valuable insights into cancer diagnosis, staging, and treatment response assessment. [19,20] This multimodal approach, combining optical and radionuclide imaging, offers a comprehensive toolbox for advancing our understanding of cancer biology and improving patient outcomes. [19] Multimodal imaging-guided antitumor therapies using engineered nanocomplexes (NCs) are making many positive progresses, including improving therapeutic efficacy and reducing adverse effects.…”

Section: Introductionmentioning

confidence: 99%

Introducing Specific Iodine Ions in Perovskite‐Based Nanocomplex to Cater for Versatile Biomedical Imaging and Tumor Radiotherapy

Yue,

Xu,

Jiang

et al. 2023

Adv Healthcare Materials

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Multimodal biomedical imaging and imaging‐guided therapy have garnered extensive attention owing to the aid of nanoagents with the aim of further improving the therapeutic efficacy of diseases. The ability to engineer nanocomplexes (NCs) or control how they behave within an organism remains largely elusive. Here, a multifunctional nanoplatform is developed based on stabilized I‐doped perovskite, CsPbBr3‐xIx@SiO2@Lip‐c(RGD)2 (PSL‐c(RGD)2) NCs. In particular, by regulating the amount of regular I− ions introduced, the fluorescence emission spectrum of perovskite‐based NCs can be modulated well to match the requirement for biomedical optical imaging at the scale from molecule, cell to mouse; doping 125I enables the nanoformulation to be competent for single‐photon emission computed tomography (SPECT) imaging; the introduction of 131I− imparts the NCs with the capability for radiotherapy. Through facile manipulation of specific iodine ions, this nanoplatform exhibits a remarkable ability to match multifunctional biomedical imaging and tumor therapy. In addition, their in vivo behavior can be manipulated by adjusting the thickness of the silica shell and the surface polarity for more practical applications. These experimental explorations offer a novel approach for engineering desirable multimodal NCs to simultaneously image and combat malignant tumors.

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Advances in PET imaging of cancer

Cited by 40 publications

References 247 publications

On the Use of Artificial Intelligence for Dosimetry of Radiopharmaceutical Therapies

On the Use of Artificial Intelligence for Dosimetry of Radiopharmaceutical Therapies

AIEgens Cross‐linked Iron Oxide Nanoparticles Synchronously Amplify Bimodal Imaging Signals in Situ by Tumor Acidity‐Mediated Click Reaction

Introducing Specific Iodine Ions in Perovskite‐Based Nanocomplex to Cater for Versatile Biomedical Imaging and Tumor Radiotherapy

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