Advances in Perioperative Pain Management: Use of Medications with Dual Analgesic Mechanisms, Tramadol &amp; Tapentadol

Nossaman, Vaughn E.; Ramadhyani, Usha; Kadowitz, Philip J.; Nossaman, Bobby D.

doi:10.1016/j.anclin.2010.08.009

Cited by 60 publications

(52 citation statements)

References 121 publications

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“…Tramadol is a centrally acting opioid analgesic which is mainly used for the treatment of moderate to severe pain [2]. Its efficiency and potency ranges between weak opioids and morphine [3].…”

Section: Introductionmentioning

confidence: 99%

Histopathological and Biochemical Effects of Acute & Chronic Tramadol drug Toxicity on Liver, Kidney and Testicular Function in Adult Male Albino Rats

2016

FRCIJ

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Background: Tramadol is becoming abused among teens; especially between males. The study aimed to investigate the histopathological and biochemical profiles of acute and chronic toxic effects of tramadol on hepatic, renal and testicular functions.Methodology: Sixty male adult albino Sprague-Dawley rats were used. Rats were divided into three groups. Group I: control. Group II: representing acute tramadol toxicity and group III: representing tramadol dependent use for 60 days.Results: Group II displayed hemorrhage and cytolysis in the hepatocytes. Group III showed complete cell membrane degeneration of hepatocytes. Renal tissues revealed glomerular hemorrhage in group II and atrophied glomerulus with collapsed tufts, degenerated tubules and cellular infiltration in group III. The testicular tissues revealed atrophy of seminiferous tubules with interstitial calcification in group II. Focal testicular degeneration, with a little evidence of spermatogenesis in group III. Biochemical indices showed significant increase in liver enzymes, serum bilirubin, creatinine and blood urea nitrogen levels. The sex hormones levels were significantly increased for estradiol and prolactin, while there was a significant decrease in testosterone with a gradual reduction in luteinizing and follicular stimulating hormones.Recommendations: Designing a national awareness campaign to the youth to spotlights on the health hazards of tramadol abuse.

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Section: Introductionmentioning

confidence: 99%

Histopathological and Biochemical Effects of Acute & Chronic Tramadol drug Toxicity on Liver, Kidney and Testicular Function in Adult Male Albino Rats

2016

FRCIJ

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“…Tramadol was administered for analgesia during the immediate postoperative period, with the first dose administered intravenously. Tramadol is an analgesic that acts centrally with several mechanisms of action (Choi et al 2011); it is a µ-opioid agonist, as well as an inhibitor of serotonin and norepinephrine synaptic re-uptake and facilitates spinal modulation of pain (Nossaman et al 2010;Lu et al 2014). This effect promotes analgesia and avoids the adverse effects of xylazine, such as respiratory depression.…”

Section: Discussionmentioning

confidence: 99%

Effects of ketamine/xylazine premedication on emulsified isoflurane general anaesthesia in swine undergoing embryo transplantation

Jiang¹,

Hu²,

Fan³

et al. 2014

Vet. Med. - Czech

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Cardiorespiratory effects were assessed during ketamine/xylazine premedication followed by emulsified isoflurane anaesthesia in swine undergoing experimental embryo transplantation. Ketamine (10 mg/kg) and xylazine (3.5 mg/kg) were premedicated intravenously, followed by continuous administration of intravenous emulsified isoflurane (2.8 ml/kg/h). Cardiorespiratory parameters, including heart rate, respiratory rate, mean arterial blood pressure, arterial oxygen saturation, and rectal temperature, were recorded in sows undergoing surgical embryo transplantation. Ketamine/xylazine premedication resulted in anaesthetic induction and lateral recumbency within 1 minute without any adverse effects. The physiological changes observed after drug administration remained within biologically acceptable limits. In conclusion, the combination of ketamine/xylazine provided anaesthetic induction, muscle relaxation, and analgesia sufficient for emulsified isoflurane intravenous anaesthesia. There were no adverse events in the experimental animals. This finding supports the use of emulsified isoflurane following ketamine/xylazine premedication in pigs.

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“…Con respecto al manejo de dolor crónico es relevante destacar aquellos opiáceos de uso ambulatorio dentro de los cuales, en nuestro país, destaca el Tramadol, ya sea en su formulación en gotas o tabletas y asimismo, en combinación con otros analgésicos, tales como Paracetamol, con el fin de reducir las dosis administradas de ambos fármacos 10,11 . Existen otros opiáceos presentes en el arsenal médico para el manejo del dolor ambulatorio, como la Codeína, opiáceo débil cuya formulación más ampliamente disponible es en jarabe, y también en tabletas que se pueden utilizar como parte del segundo escalón analgésico de las guías de la OMS.…”

Section: Opiáceos De Prescripción Médicaunclassified

Manejo del dolor: Trastorno por uso de opiáceos de prescripción médica y su relación con la práctica clínica

Herrera¹,

Rolle²,

Babul³

et al. 2017

Rev Chil Anest

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Advances in Perioperative Pain Management: Use of Medications with Dual Analgesic Mechanisms, Tramadol & Tapentadol

Cited by 60 publications

References 121 publications

Histopathological and Biochemical Effects of Acute & Chronic Tramadol drug Toxicity on Liver, Kidney and Testicular Function in Adult Male Albino Rats

Histopathological and Biochemical Effects of Acute & Chronic Tramadol drug Toxicity on Liver, Kidney and Testicular Function in Adult Male Albino Rats

Effects of ketamine/xylazine premedication on emulsified isoflurane general anaesthesia in swine undergoing embryo transplantation

Manejo del dolor: Trastorno por uso de opiáceos de prescripción médica y su relación con la práctica clínica

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