Advances in Nanomaterials for Drug Delivery

Veloso, Sérgio Rafael Silva; Castanheira, Elisabete M. S.

doi:10.3390/biomedicines11020399

Cited by 2 publications

(6 citation statements)

References 11 publications

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“…76 A broad spectrum of cytokine profiles was observed, and it was demonstrated that the plasma level of E2 was twice as high as the normal level. 76 Wang et al investigated the neurological characteristic of methylhistamine (MH), which could target the recurrent process that is activated during an injury, to identify a potential therapeutic intervention for the treatment of PNI. To produce a drug with a sustained release, a complex was produced of the pharmaceutical with Dx sulfate by using an interaction that was supported by metal ions.…”

Section: Agarose (Ag) Based Polysaccharide Drug Delivery Systems For ...mentioning

confidence: 99%

“…For neuroprotection in SCI, Cox et al 78 made PLGA Nps which is full of estrogen (E2). 76 A rat model of spinal cord injury that ranged from mild to severe was utilized to assess the effectiveness of the scaffold. To create the framework, the E2-loaded PLGA Nps that were produced via the nanoprecipitation process were combined with an AG hydrogel.…”

Section: Agarose (Ag) Based Polysaccharide Drug Delivery Systems For ...mentioning

confidence: 99%

“…In an in vivo model, the researchers demonstrated that their bioengineered scaffold can both support and guide the development of axons, and this development of axons is done by cutting the spinal cord of a rat in half. For neuroprotection in SCI, Cox et al 78 made PLGA Nps which is full of estrogen (E2) 76 . A rat model of spinal cord injury that ranged from mild to severe was utilized to assess the effectiveness of the scaffold.…”

Section: The Current State Of Polysaccharide‐based Drug Delivery Syst...mentioning

confidence: 99%

“…A rat model of spinal cord injury that ranged from mild to severe was utilized to assess the effectiveness of the scaffold. To create the framework, the E2‐loaded PLGA Nps that were produced via the nanoprecipitation process were combined with an AG hydrogel 76 . A broad spectrum of cytokine profiles was observed, and it was demonstrated that the plasma level of E2 was twice as high as the normal level 76 .…”

Section: The Current State Of Polysaccharide‐based Drug Delivery Syst...mentioning

confidence: 99%

“…To create the framework, the E2‐loaded PLGA Nps that were produced via the nanoprecipitation process were combined with an AG hydrogel 76 . A broad spectrum of cytokine profiles was observed, and it was demonstrated that the plasma level of E2 was twice as high as the normal level 76 . Wang et al investigated the neurological characteristic of methylhistamine (MH), which could target the recurrent process that is activated during an injury, to identify a potential therapeutic intervention for the treatment of PNI.…”

Section: The Current State Of Polysaccharide‐based Drug Delivery Syst...mentioning

confidence: 99%

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Management of peripheral nerve injuries using natural based biomaterials and their derivatives: Advances and prospective

Kumar,

Malviya,

Sundram

2024

MedComm – Biomaterials and Applications

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The management of peripheral nerve injuries is an important concern due to the their incidence of nerve lesions and inappropriate regeneration that follows severe injuries, which ultimately reduces the lives of patients with this condition. Different strategies have been investigated to repair severe nerve injuries with the improvement of motor and sensory regeneration. Although autograft remains the gold standard technique, an emerging number of research articles concerning nerve conduit use have been reported in the last few years. Nerve conduits aim to overcome autograft disadvantages, but they satisfy some requirements to be suitable for nerve repair. A universal ideal conduit does not exist since conduit properties have to be evaluated case by case; nevertheless, because of their high biocompatibility and biodegradability, natural‐based biomaterials have great potential to be used to produce nerve guides. Although they have many characteristics with synthetic biomaterials, natural‐based biomaterials are preferable because of their extraction sources; indeed, these biomaterials are obtained from different renewable sources or food waste, thus reducing environmental impact and enhancing sustainability in comparison to synthetic ones. This review highlights the recent progress in the development of natural‐based biomaterials and their derivatives for the management of peripheral nerve injuries.

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Section: Agarose (Ag) Based Polysaccharide Drug Delivery Systems For ...mentioning

confidence: 99%

Section: Agarose (Ag) Based Polysaccharide Drug Delivery Systems For ...mentioning

confidence: 99%

Section: The Current State Of Polysaccharide‐based Drug Delivery Syst...mentioning

confidence: 99%

Section: The Current State Of Polysaccharide‐based Drug Delivery Syst...mentioning

confidence: 99%

Section: The Current State Of Polysaccharide‐based Drug Delivery Syst...mentioning

confidence: 99%

See 3 more Smart Citations

Management of peripheral nerve injuries using natural based biomaterials and their derivatives: Advances and prospective

Kumar,

Malviya,

Sundram

2024

MedComm – Biomaterials and Applications

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An updated review on acne

Gurung¹,

Badola²

2023

World J. Bio. Pharm. Health Sci.

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Acne is a common chronic inflammatory skin disorder that affects individuals of all ages, particularly during adolescence. It is characterized by the formation of comedones, papules, pustules, and, in severe cases, nodules and cysts. While acne is primarily associated with the pilosebaceous unit, its pathogenesis involves multiple factors, including hormonal imbalances, increased sebum production, abnormal follicular keratinization, and the colonization of Propionibacterium acnes.This review aims to provide an updated understanding of acne, focusing on its pathogenesis, clinical presentation, and current management strategies. The pathogenesis of acne involves complex interactions between hormones, sebum production, follicular keratinization, and inflammation. Various predisposing factors, such as genetic susceptibility, diet, and environmental influences, also contribute to the development and exacerbation of acne. Management of acne encompasses a multifaceted approach, including topical and systemic therapies. Topical agents such as retinoids, benzoyl peroxide, and antibiotics target different aspects of acne pathogenesis, helping to normalize follicular keratinization, reduce inflammation, and inhibit bacterial growth. Systemic therapies, including oral antibiotics, hormonal agents, and isotretinoin, are often used for moderate to severe cases or those resistant to topical treatments. Additionally, this review highlights emerging therapies and advancements in acne management. Recent research has explored novel treatment options such as laser and light-based therapies, photodynamic therapy, and the use of probiotics and botanical extracts. These interventions show promise in targeting specific aspects of acne pathogenesis and reducing treatment-related adverse effects. Furthermore, the psychological impact of acne and its influence on quality of life are discussed. Acne can significantly affect an individual's self-esteem, body image, and social interactions, underscoring the importance of a holistic approach to patient care. In conclusion, this updated review provides a comprehensive overview of acne, including its pathogenesis, current treatment strategies, and emerging therapies. Understanding the multifactorial nature of acne and staying abreast of advancements in its management will help healthcare professionals provide effective and individualized care to patients suffering from this common dermatological condition. Acne is a common chronic inflammatory skin disorder that affects individuals of all ages, particularly during adolescence. It is characterized by the formation of comedones, papules, pustules, and, in severe cases, nodules and cysts. While acne is primarily associated with the pilosebaceous unit, its pathogenesis involves multiple factors, including hormonal imbalances, increased sebum production, abnormal follicular keratinization, and the colonization of Propionibacterium acnes.This review aims to provide an updated understanding of acne, focusing on its pathogenesis, clinical presentation, and current management strategies. The pathogenesis of acne involves complex interactions between hormones, sebum production, follicular keratinization, and inflammation. Various predisposing factors, such as genetic susceptibility, diet, and environmental influences, also contribute to the development and exacerbation of acne. Management of acne encompasses a multifaceted approach, including topical and systemic therapies. Topical agents such as retinoids, benzoyl peroxide, and antibiotics target different aspects of acne pathogenesis, helping to normalize follicular keratinization, reduce inflammation, and inhibit bacterial growth. Systemic therapies, including oral antibiotics, hormonal agents, and isotretinoin, are often used for moderate to severe cases or those resistant to topical treatments. Additionally, this review highlights emerging therapies and advancements in acne management. Recent research has explored novel treatment options such as laser and light-based therapies, photodynamic therapy, and the use of probiotics and botanical extracts. These interventions show promise in targeting specific aspects of acne pathogenesis and reducing treatment-related adverse effects. Furthermore, the psychological impact of acne and its influence on quality of life are discussed. Acne can significantly affect an individual's self-esteem, body image, and social interactions, underscoring the importance of a holistic approach to patient care. In conclusion, this updated review provides a comprehensive overview of acne, including its pathogenesis, current treatment strategies, and emerging therapies. Understanding the multifactorial nature of acne and staying abreast of advancements in its management will help healthcare professionals provide effective and individualized care to patients suffering from this common dermatological condition.

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Advances in Nanomaterials for Drug Delivery

Abstract: In recent years, nanomedicine has provided several high-performance tools for overcoming biomedical challenges, resulting in numerous patents [...]

Cited by 2 publications

References 11 publications

Management of peripheral nerve injuries using natural based biomaterials and their derivatives: Advances and prospective

Management of peripheral nerve injuries using natural based biomaterials and their derivatives: Advances and prospective

An updated review on acne

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