Advances in Nanofabrication Technology for Nutraceuticals: New Insights and Future Trends

Abstract

Bioactive components such as polyphenolics, flavonoids, bioactive peptides, pigments, and essential fatty acids were known to ward off some deadliest diseases. Nutraceuticals are those beneficial compounds that may be food or part of food that has come up with medical or health benefits. Nanoencapsulation and nanofabricated delivery systems are an imminent approach in the field of food sciences. The sustainable fabrication of nutraceuticals and biocompatible active components indisputably enhances the food grade and promotes good health. Nanofabricated delivery systems include carbohydrates-based, lipids (solid and liquid), and proteins-based delivery systems. Solid nano-delivery systems include lipid nanoparticles. Liquid nano-delivery systems include nanoliposomes and nanoemulsions. Physicochemical properties of nanoparticles such as size, charge, hydrophobicity, and targeting molecules affect the absorption, distribution, metabolism, and excretion of nano delivery systems. Advance research in toxicity studies is necessary to ensure the safety of the nanofabricated delivery systems, as the safety of nano delivery systems for use in food applications is unknown. Therefore, improved nanotechnology could play a pivotal role in developing functional foods, a contemporary concept assuring the consumers to provide programmed, high-priced, and high-quality research toward nanofabricated delivery systems.

Transformation of Agro-Waste into Value-Added Bioproducts and Bioactive Compounds: Micro/Nano Formulations and Application in the Agri-Food-Pharma Sector

“…Therefore, it is necessary to design eco-friendly and cost-effective cascade conversion techniques. Agricultural waste is seen as a nutritional and functional raw resource that can be utilized in numerous applications, making it a viable solution to economic and environmental issues [89,90]. They can be employed directly as protein, fat, vitamin, fiber, carbohydrate, mineral, and antioxidant dietary components.…”

Current trends in nano-delivery systems for functional foods: a systematic review

“…The adaptability and versatility of the chemical composition, and various functional groups in protein, form several complexes with polysaccharides, lipids, or other biopolymers allowing their interaction with a diverse group of bioactive compounds and nutrients, and increase their potential application in food ( Ha et al, 2019 ; Lin et al, 2021 ). The various molecular and physicochemical properties of proteins, such as size, shape, charge, surface properties, water dispersibility, colloidal stability and stability, determine their utility ( Puttasiddaiah et al, 2022 ; Zhou et al, 2020 ). The versatile composition of proteins affords several interactions including covalent, electrostatic, and hydrophobic.…”

“…Protein-based NDS can be produced using a variety of techniques which can simple and cost-effective, including coacervation, gelation, spray drying, and electro-hydrodynamic processes ( Fathi, Donsi & McClements, 2018 ; Puttasiddaiah et al, 2022 ). The selection of method is dependent on several factors including availability of materials and equipment, stability, compatibility, release mechanism and conditions, biodegradability, economic feasibility, application, function to be enhanced, and storage ( Fathi, Donsi & McClements, 2018 ; Martínez-Álvarez, Calvo & Gómez-Estaca, 2020 ; Rajendran, Udenigwe & Yada, 2016 ).…”

Attenuation of Hyperlipidemia by Medicinal Formulations of Emblica officinalis Synergized with Nanotechnological Approaches

“…The toxicity evaluation of nanoscale materials and with their multiple delivery methods for active principles and nutritional supplements is of utmost priority. The use of novel functional materials could be accompanied by a number of safety concerns and require the implementation of speculative practices that consider human health and safety [117].…”