Transformation of Agro-Waste into Value-Added Bioproducts and Bioactive Compounds: Micro/Nano Formulations and Application in the Agri-Food-Pharma Sector

Bala, Shashi; Garg, Diksha; Sridhar, Kandi; Inbaraj, Baskaran Stephen; Singh, Ranjan; Kamma, Srinivasulu; Tripathi, Manikant; Sharma, Minaxi

doi:10.3390/bioengineering10020152

Cited by 73 publications

(29 citation statements)

References 92 publications

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“…Thus, the values of the factors that optimize the value of the response variable are established. The mathematical model of the response surface is shown in Equation (1).…”

Section: Optimization Process With Experimental Designsmentioning

confidence: 99%

“…Ethanol is recognized as safe by the FDA [19]. The maceration time (1,4,12,20, and 24 h) and the ratio of ethanol acidified with 1% HCl were the two factors studied. Each determination was performed in an amber vial at 23 • C, using 1 g of sample in 10 mL of solvent.…”

Section: Extraction By Macerationmentioning

confidence: 99%

“…Thus, technologies have been developed to manufacture high-value-added products from waste. Some of the industries that generate the most waste are related to the production and transformation of food [1]. In the present work, residues from the wine industry were used as raw materials because they are a natural source of antioxidants and have various compounds that are beneficial for health [2,3].…”

Section: Introductionmentioning

confidence: 99%

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Optimization of the Extraction of Bioactive Compounds from Cabernet Sauvignon Grape Pomace from Querétaro, Mexico, Using MSPD

Daniela,

del Socorro,

Fortunata

et al. 2023

Separations

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Red wine contains polyphenols which are extracted during the winemaking process. However, winemaking is not an extraction; therefore, the resulting byproducts still have a substantial polyphenol content. The aim of this study was to compare two methods for the extraction of phenolic compounds: maceration and matrix solid-phase dispersion (MSPD). Grape pomace (Vitis vinifera var. Cabernet Sauvignon) from a winery in Querétaro, Mexico was used. The optimal conditions for both methods were identified. Phenolic compounds and antioxidant activity were the response variables. A central composite design was used (Minitab 17) for the extraction by maceration. The maceration time (1, 4, 12, 20, and 24 h) and the ratio of ethanol (50 to 80%) acidified with 1% HCl were the two factors studied. For the MSPD extraction, sea sand was used as a dispersant, and a 22 factorial design was employed for the evaluation, with the elution volume and the ratio of sample/dispersant being the two factors analyzed. The optimal extraction method was MSPD with 96 mL (acidified ethanol) as the elution volume and a 1:2 ratio of sample/dispersant. Using these conditions, 14.01 ± 0.19 mMol TEAC/100 g db (Trolox equivalent of antioxidant capacity) of grape pomace was obtained, whereas the total phenolic content was 2836.73 ± 41.90 mg GAE/100 g db. These values are greater than those obtained by maceration. These conditions are close to those predicted by the model (analysis of variance (ANOVA) with a level of significance of 5% (p < 0.05) and a Tukey comparison test for determining significant differences in the comparison of results).

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“…Thus, the values of the factors that optimize the value of the response variable are established. The mathematical model of the response surface is shown in Equation (1).…”

Section: Optimization Process With Experimental Designsmentioning

confidence: 99%

Section: Extraction By Macerationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Optimization of the Extraction of Bioactive Compounds from Cabernet Sauvignon Grape Pomace from Querétaro, Mexico, Using MSPD

Daniela,

del Socorro,

Fortunata

et al. 2023

Separations

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“…Untreated waste may cause serious pollution for the environment, which is becoming a threat to global health and food security [1]. However, agricultural waste (AW) is rich in essential nutrients, such as proteins, lipids, glucid, and minerals, and as such, AW may be used for many purposes [2,3]. Recently, recycling AW for the bioproduction of valuable secondary metabolites via bacterial conversion has become an emerging topic [1,4].…”

Section: Introductionmentioning

confidence: 99%

Bioconversion of a Peanut Oil Processing By-Product into a Novel α-Glucosidase Inhibitor: Hemi-Pyocyanin

2023

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Hemi-pyocyanin (HPC) is a heterocyclic nitrogenous compound with some reported potential medical effects. The current report aimed to investigate the potential use of organic industrial waste for the production of HPC via microbial fermentation. The novel antidiabetic activity of HPC was also accessed and reported in this work. A peanut oil processing by-product (groundnut cake) was screened as the best substrate for Pseudomonas aeruginosa TUN03 conversion to obtain high-yield HPC. This compound was further produced in a 14 L bioreactor system on a large scale (6 L per pilot) and reached higher productivity (35.1 μg/mL) in a shorter time course of cultivation (8 h) compared to fermentation on a small scale in flasks (19.5 μg/mL; 3 days of fermentation). On assessing its activity, HPC demonstrated potent inhibition against α-glucosidase, an antidiabetic enzyme, with a low IC50 value (0.572 mg/mL) and a maximum inhibition rate of 100%. In an in silico study, HPC was found to inhibit α-glucosidase with a good binding energy score (−9.0 kcal/mol) via interaction with amino acids Lys156, Leu313, and Arg315 at the active site, and three bonds (1 H-acceptor and 2 pi-H) were generated. The data from five Lipkin’s rules and ADMET-based pharmacokinetics and pharmacology revealed that HPC possesses drug-like properties and good ADMET properties within the required allotted limitations. The data obtained in the current work highlighted the potential application of groundnut cakes for the eco-friendly and scaled-up production of HPC, a new anti-α-glucosidase agent that should be further investigated for type 2 diabetes management.

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“…In other words, pretreatment is the crucial and costly unit process in converting lignocellulosic materials into fuels [1]. Various methods are therefore used for pretreatment which may be physical (milling/grinding, microwave, irradiation ultrasonic), chemical (acid or alkaline) or biological (bacteria, fungi or enzymatic) [3].…”

Section: Introductionmentioning

confidence: 99%

Optimization of Some Fermentation Conditions for Bioethanol Production from Yam Peels (Dioscorea rotundata) Using Box-Behnken Design (BBD)

Saulawa,

Nura,

Bala

et al. 2023

JAMB

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Aim: The aim of this research was to optimize the production of bioethanol from a select second generation feedstock (yam peels). Methodology: Bioethanol was produced from yam peels using Box Behnken Design (BBD). The independent variables selected for optimization of bioethanol yield were; fermentation temperature (˚C), fermentation time (hours) and yeast concentration (%w/v). A set of 17 experiments were considered by design expert software. All experiments were run in triplicates. Test for bioethanol was carried out using acidified potassium dichromate method and absorbance was taken using a spectrophotometer at 600nm. Results: From the experiments carried out above, the optimum conditions under which the highest bioethanol (yield%) was produced were a fermentation temperature of 30̊C, yeast concentration of 5.50%w/v and fermentation time of 96hours under which a bioethanol yield of 45.79% was produced. Conclusion: Yam peels may therefore have the potentials to serve as substrates for bioethanol production rather than using food crops such as sugarcane juice and cassava flesh which may lead to food shortages and crisis especially is developing countries such as Nigeria.

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Transformation of Agro-Waste into Value-Added Bioproducts and Bioactive Compounds: Micro/Nano Formulations and Application in the Agri-Food-Pharma Sector

Cited by 73 publications

References 92 publications

Optimization of the Extraction of Bioactive Compounds from Cabernet Sauvignon Grape Pomace from Querétaro, Mexico, Using MSPD

Optimization of the Extraction of Bioactive Compounds from Cabernet Sauvignon Grape Pomace from Querétaro, Mexico, Using MSPD

Bioconversion of a Peanut Oil Processing By-Product into a Novel α-Glucosidase Inhibitor: Hemi-Pyocyanin

Optimization of Some Fermentation Conditions for Bioethanol Production from Yam Peels (Dioscorea rotundata) Using Box-Behnken Design (BBD)

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