Advances in imprinting strategies for selective virus recognition a review

Gast, Michael J.; Sobek, Harald; Mizaikoff, Boris

doi:10.1016/j.trac.2019.03.010

Cited by 65 publications

(52 citation statements)

References 80 publications

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“…A broad range of markers associated with infectious diseases such as antibiotics [35], lipopolysaccharides [36], nucleotides [37], toxin proteins [38,39], virus [40,41], bacteria [42,43], and fungi [7] cells have been successfully used as templates in synthesizing MIPs/SIPs. Gast et al [12] highlighted synthesis strategies for virus imprinted polymers. Nowadays, double-templates [44,45] and multi-templates [46] methods have been developed, which makes MIPs/SIPs based-biosensors able to detect more target analytes in one complex sample.…”

Section: Preparation Of Mips/sips For Electrochemical Biosensormentioning

confidence: 99%

“…In this review, current trends in the development of MIPs/SIPs based electrochemical biosensors for rapid assessment of the infectious diseases, as well as future research directions are comprehensively summarized and discussed. Virus-imprinted polymers (VIPs) [12] for virus detection and cell-imprinted polymers (CIPs) [13] for bacteria detection are highlighted ( Figure 1).…”

Section: Introductionmentioning

confidence: 99%

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Molecularly Imprinted Polymers and Surface Imprinted Polymers Based Electrochemical Biosensor for Infectious Diseases

Cui

Zhou

2020

Sensors

147

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Owing to their merits of simple, fast, sensitive, and low cost, electrochemical biosensors have been widely used for the diagnosis of infectious diseases. As a critical element, the receptor determines the selectivity, stability, and accuracy of the electrochemical biosensors. Molecularly imprinted polymers (MIPs) and surface imprinted polymers (SIPs) have great potential to be robust artificial receptors. Therefore, extensive studies have been reported to develop MIPs/SIPs for the detection of infectious diseases with high selectivity and reliability. In this review, we discuss mechanisms of recognition events between imprinted polymers with different biomarkers, such as signaling molecules, microbial toxins, viruses, and bacterial and fungal cells. Then, various preparation methods of MIPs/SIPs for electrochemical biosensors are summarized. Especially, the methods of electropolymerization and micro-contact imprinting are emphasized. Furthermore, applications of MIPs/SIPs based electrochemical biosensors for infectious disease detection are highlighted. At last, challenges and perspectives are discussed.

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Section: Preparation Of Mips/sips For Electrochemical Biosensormentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Molecularly Imprinted Polymers and Surface Imprinted Polymers Based Electrochemical Biosensor for Infectious Diseases

Cui

Zhou

2020

Sensors

147

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“…It is worth noting that the methods used to measure the binding properties and binding models used for both aptamers and MIPs are completely different [35][36][37]. A reverse in binding performance is seen as we increase the size of the target molecule, whereby the binding affinities for aptamers generally increase while MIPs start to suffer from performance issues in terms of specificity, due to the lack of compatible monomers and increased chances of non-specific binding [38,39]. This non-specific binding is due to the large surface area available around the MIP material, which can act as sites for non-specific interactions with the sample matrix and structurally related analytes and the lack of accessibility on the MIP surface for larger templates, such as cells and proteins.…”

Section: The Development Of Aptamers and Mipsmentioning

confidence: 99%

“…Major environmental viruses are known to be hepatitis A and E viruses, norovirus, astrovirus, and rotavirus [97,110]. Virus imprinting has shown very promising outcomes for the diagnosis of virus-associated diseases [38]. However, the application of aptasensors for environmental viruses is still in its infancy despite the flourishing outcomes for virus detection using aptamers [111].…”

Section: Virus Detectionmentioning

confidence: 99%

The Use of Aptamers and Molecularly Imprinted Polymers in Biosensors for Environmental Monitoring: A Tale of Two Receptors

et al. 2020

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Effective molecular recognition remains a major challenge in the development of robust receptors for biosensing applications. Over the last three decades, aptamers and molecularly imprinted polymers (MIPs) have emerged as the receptors of choice for use in biosensors as viable alternatives to natural antibodies, due to their superior stability, comparable binding performance, and lower costs. Although both of these technologies have been developed in parallel, they both suffer from their own unique problems. In this review, we will compare and contrast both types of receptor, with a focus on the area of environmental monitoring. Firstly, we will discuss the strategies and challenges involved in their development. We will also discuss the challenges that are involved in interfacing them with the biosensors. We will then compare and contrast their performance with a focus on their use in the detection of environmental contaminants, namely, antibiotics, pesticides, heavy metals, and pathogens detection. Finally, we will discuss the future direction of these two technologies.

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“…Molecularly imprinted polymers and their target molecules mimic the recognition mechanism of biological systems such as antibodies/antigens or enzymes/inhibitors in synthetic polymeric structures (Mosbach & Ramström, ). MIPs have been produced to capture a broad range of compounds, from low‐molecular‐weight structures to metal ions (Aslıyüce et al, ), pharmaceuticals, environmental pollutants (Üzek, Sari, Şenel, Denizli, & Merkoçi, ), proteins (Perçin, Idil, & Denizli, ), virus particles (Gast, Sobek, & Mizaikoff, ) and even whole microbial cells (Idil, Hedström, Denizli, & Mattiasson, ). There are applications in both bioseparation and diagnostics (Bereli et al, ; Bereli, Saylan, Uzun, Say, & Denizli, ; Ertürk, Özen, Tümer, Mattiasson, & Denizli, ; Uzun, Say, Ünal, & Denizli, ).…”

Section: Introductionmentioning

confidence: 99%

Combined protein A imprinting and cryogelation for production of spherical affinity material

Aslıyüce

Mattìasson

Deni̇zli̇

2019

Biomedical Chromatography

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Cryogels have been demonstrated to be efficient when applied for protein isolation.Owing to their macroporous structure, cryogels can also be used for treating particle-containing material, e.g. cell homogenates. Another challenging development in protein purification technology is the use of molecularly imprinted polymers (MIPs).These MIPs are robust and can be used repeatedly. The paper presents a new technology that combine the formation of cryogel beads concomitantly with making imprints of a protein. Protein A was chosen as the print molecule which was also be the target in the purification step. The present paper describes a new method to produce protein-imprinted cryogel beads. The protein-imprinted material was characterized and the separation properties were evaluated with regard to both the target protein and whole cells with target protein exposed on the cell surface. The maximum protein A adsorption was 18.1 mg/g of wet cryogel beads. The selectivity coefficient of protein A-imprinted cryogel beads for protein A was 5.44 and 12.56 times greater than for the Fc fragment of IgG and protein G, respectively.

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Advances in imprinting strategies for selective virus recognition a review

Cited by 65 publications

References 80 publications

Molecularly Imprinted Polymers and Surface Imprinted Polymers Based Electrochemical Biosensor for Infectious Diseases

Molecularly Imprinted Polymers and Surface Imprinted Polymers Based Electrochemical Biosensor for Infectious Diseases

The Use of Aptamers and Molecularly Imprinted Polymers in Biosensors for Environmental Monitoring: A Tale of Two Receptors

Combined protein A imprinting and cryogelation for production of spherical affinity material

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