Advances in Imaging the Brain–Gut Axis: Functional Gastrointestinal Disorders

Tillisch, Kirsten; Labus, Jennifer S.

doi:10.1053/j.gastro.2010.12.014

Cited by 64 publications

(43 citation statements)

References 27 publications

(27 reference statements)

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“…Hypnotherapy may also act on central nervous system processes, because FAP and IBS may be caused by altered central modulation of visceral stimuli. Pain processing regions in the brain, such as the anterior cingulated cortex and amygdala, appear to react more extensively in adult IBS patients,36 and hypnotherapy seems to reduce this activity in these brain regions 37 38. To date, no trials evaluating these brain regions in paediatric IBS patients after hypnotherapy are available.…”

Section: Discussionmentioning

confidence: 99%

Gut-directed hypnotherapy for functional abdominal pain or irritable bowel syndrome in children: a systematic review

Rütten

Reitsma

Vlieger

et al. 2012

Archives of Disease in Childhood

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Objectives Gut directed hypnotherapy (HT) is shown to be effective in adult functional abdominal pain (FAP) and irritable bowel syndrome (IBS) patients. We performed a systematic review to assess efficacy of HT in paediatric FAP/IBS patients. Methods We searched Medline, Embase, PsychINFO, Cumulative Index to Nursing and Allied Health Literature databases and Cochrane Central Register of Controlled Trials for randomised controlled trials (RCT) in children with FAP or IBS, investigating efficacy of HT on the following outcomes: abdominal pain scores, quality of life, costs and school absenteeism.

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Section: Discussionmentioning

confidence: 99%

Gut-directed hypnotherapy for functional abdominal pain or irritable bowel syndrome in children: a systematic review

Rütten

Reitsma

Vlieger

et al. 2012

Archives of Disease in Childhood

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“…A growing number of reports on brain imaging results obtained in patients with chronic abdominal pain have been published during the last decade [51; 66], and have lead to some insights into the understanding of central aspects of visceral pain modulation in humans. A previous review of positron emission tomography (PET) and functional MRI studies published between 1997 and 2008, found that even though there were wide variations in terms of methods of stimulation, study procedures, study populations and number of subjects and image analysis, the most consistently activated brain regions in all reports were the insular (INS) and anterior cingulate cortices (ACC), followed by primary sensory cortex (S1), prefrontal cortex (PFC), posterior parietal cortex (PPC) and thalamus (THAL) [51].…”

Section: Functional Mri Studies Published Between 1997 and 2008mentioning

confidence: 99%

Imaging brain mechanisms in chronic visceral pain

Mayer

Gupta

Kilpatrick

et al. 2015

Pain

116

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Chronic visceral pain syndromes are important clinical problems with largely unmet medical needs. Based on the common overlap with other chronic disorders of visceral or somatic pain, mood and affect, and their responsiveness to centrally targeted treatments, an important role of central nervous system in their pathophysiology is likely. A growing number of brain imaging studies in irritable bowel syndrome, functional dyspepsia and bladder pain syndrome/interstitial cystitis has identified abnormalities in evoked brain responses, resting state activity and connectivity, as well as in grey and white matter properties. Structural and functional alterations in brain regions of the salience, emotional arousal, and sensorimotor networks, as well as in prefrontal regions, are the most consistently reported findings. Some of these changes show moderate correlations with behavioral and clinical measures. Most recently, data driven machine-learning approaches to larger data sets have been able to classify visceral pain syndromes from healthy control subjects. Future studies need to identify the mechanisms underlying the altered brain signatures of chronic visceral pain and identify targets for therapeutic interventions.

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“…Advanced imaging techniques have used functional magnetic resonance imaging, magnetoencephalography, and positron emission tomography for interrogating neuronal pathways. If metagenomic techniques applied to the gut microbiota in conjunction with brain imaging, researchers will surely identify instigators of injury associated with the GBA, and the findings will correlate with human health and disease (106)(107)(108).…”

Section: Neonatal Nutrition and Modifications Of Gba Functionmentioning

confidence: 99%