Advances in image reconstruction software in nuclear cardiology: Is all that glitters gold?

Marcassa, Claudio; Zoccarato, Orazio

doi:10.1007/s12350-016-0534-z

Cited by 5 publications

(4 citation statements)

References 27 publications

(17 reference statements)

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“…Using an anthropomorphic phantom already considered in previous publications, 9 – 11 a stress PD was simulated in different myocardial territories and acquired with a Cadmium-Zinc-Telluride (CZT)-based camera and a conventional gamma camera, with the filter-back projection (FBP) algorithm or an iterative algorithm with resolution recovery.…”

Section: Methodsmentioning

confidence: 99%

Optimal 99mTc activity ratio in the single-day stress-rest myocardial perfusion imaging protocol: A multi-SPECT phantom study

Zoccarato

Matheoud

Lecchi³

et al. 2021

Journal of Nuclear Cardiology

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Background This investigation used image data generated by an anthropomorphic phantom to determine the minimal 99m Tc rest-stress activity concentration ratio ( R ) able to minimize the ghosting effect in the single-day stress-first myocardial perfusion imaging, using different positions of the perfusion defect (PD), scanners and reconstruction protocols. Methods A cardiac phantom with a simulated PD was imaged under different R using different gamma cameras and reconstruction algorithms. The residual activity from precedent stress administration was simulated by modeling effective half-times in each compartment of the phantom and assuming a delay of 3 hours between the stress and rest studies. The net contrast (NC) of the PD in the rest study was assessed for different R , PD positions and scanner/software combinations. The optimal R will be the one that minimize the NC in the rest images Results The activity concentration ratio R , the position of the PD and the scanner/software combinations were all main effects with a statistically significant impact on the NC, in decreasing order of relevance. The NC diminished significantly only for R values up to 2. No further improvement was observed for NC for R values above 2 and up to 3. NC was significantly higher in anteroseptal than in posterolateral positions of the PD and higher for solid-state cameras. Conclusions A rest-stress activity concentration ratio R of 2 in single-day stress-first myocardial perfusion imaging is enough to achieve the maximum net contrast in the PD. This ratio should be used to optimize patient’s radiation exposure. Electronic supplementary material The online version of this article (10.1007/s12350-020-02290-2) contains supplementary material, which is available to authorized users.

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Section: Methodsmentioning

confidence: 99%

Optimal 99mTc activity ratio in the single-day stress-rest myocardial perfusion imaging protocol: A multi-SPECT phantom study

Zoccarato

Matheoud

Lecchi³

et al. 2021

Journal of Nuclear Cardiology

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“…Procedures that utilize radionuclides, should be performed in accordance with the ALARA principle: 'As Low As Reasonably Achievable' in order to keep the radiation dose as low as possible. During the last years, clinical research have demonstrated that radiation dose in SPECT imaging can be reduced due new technical advances in hardware and improved reconstruction algorithms [2][3][4][5][6][7][8]. Most modern software uses maximum-likelihood (ML) based iterative reconstruction algorithms [9].…”

Section: Introductionmentioning

confidence: 99%

“…These algorithms were improved by incorporating attenuation correction, physical modeling of collimator and detector, as well as resolution recovery. It was demonstrated clinically that the improved algorithms provide good image quality despite reduced counting statistics [2][3][4][5][6][7][8]. Unfortunately the ML approach has fundamental limitations in solving reconstruction problems with limited data since unexpected artifacts may arise despite advanced processing techniques.…”

Section: Introductionmentioning

confidence: 99%

“…In the works [2][3][4][5][6][7][8], opportunities to reduce radiation dose were investigated in real clinical practice using standard and 'half-time' DA schemes and improved ML-based reconstruction algorithms. An advantage of the numerical simulation methodology is that knowing the exact phantom, we can study, evaluate and compare various DA schemes and reconstruction algorithms to improve medical imaging techniques.…”

Section: Introductionmentioning

confidence: 99%

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A study of myocardial perfusion SPECT imaging with reduced radiation dose using maximum likelihood and entropy-based maximuma posterioriapproaches

Denisova

Terekhov²

2016

Biomed. Phys. Eng. Express

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Simulation method is a powerful tool for the study of myocardial perfusion SPECT imaging to compare different reconstruction algorithms and methods and to optimize image quality, acquisition protocol and patient radiation dose. Mathematical modeling and computer simulations of myocardial perfusion SPECT imaging are performed in this paper. Mathematical model of torso (MMT-1) to describe a Tc-99m distribution in a thoracic part of a patient body is designed. A realistic pathological case with the myocardial left ventricle defect is modeled and studied. Data acquisition (DA) model which includes the effect of non-uniform attenuation, 3D collimator-detector response and Poisson statistics is developed. DA model was verified by comparison of the calculated point source images with the standard clinical 'Syringe test' measurements, performed in the Novosibirsk Research Institute of Circulation Pathology. The projection data for the MMT-1 phantom were calculated for 60 views in accordance with the standard myocardial perfusion SPECT imaging protocol. The simulated data are in a good agreement with the clinical planar images. OSEM and entropy-based MAP (MAP-ENT) algorithms with 3D resolution recovery and attenuation correction were evaluated for their efficacy in the myocardial defect reconstructions with standard and reduced radiopharmaceutical/activity doses. The results of simulations have shown that the MAP-ENT algorithm is a promising approach to SPECT with reduced radiopharmaceutical dose. The main difference between OSEM and MAP-ENT is that the MAP-ENT iterative process can be stopped using convergence criteria that excludes a subjective factor and uncertainty of OSEM stopping.

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Clinical Nuclear Imaging Physics

Nelson

Mann

2020

Clinical Imaging Physics

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Advances in image reconstruction software in nuclear cardiology: Is all that glitters gold?

Cited by 5 publications

References 27 publications

Optimal 99mTc activity ratio in the single-day stress-rest myocardial perfusion imaging protocol: A multi-SPECT phantom study

Optimal 99mTc activity ratio in the single-day stress-rest myocardial perfusion imaging protocol: A multi-SPECT phantom study

A study of myocardial perfusion SPECT imaging with reduced radiation dose using maximum likelihood and entropy-based maximuma posterioriapproaches

Clinical Nuclear Imaging Physics

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