2003
DOI: 10.1186/bcr742
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Advances in estrogen receptor biology: prospects for improvements in targeted breast cancer therapy

Abstract: 39 AIB1 = amplified in breast cancer; AF-1 = activation function-1; AF-2 = activation function-2; cAMP = cyclic AMP; CBP = CREB-binding protein; DES = diethylstilbestrol; E2 = 17β-estradiol; ER = estrogen receptor; ERE = estrogen response element; EGF = epidermal growth factor; EGFR = epidermal growth factor receptor; FDA = Food and Drug Administration; HAT = histone acetyltransferase; IGF1 = insulin-like growth factor-1; LBD = ligand-binding domain; MAPK = mitogen-activated protein kinase; NR = nuclear recept… Show more

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Cited by 172 publications
(131 citation statements)
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References 175 publications
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“…Hormone replacement therapy is the use of exogenous estrogen in order to maintain certain normal functions in the body. The use of phytoestrogens as a replacement of estradiol being used in HRT to decrease cancer risk is then developed, thus categorized as chemopreventive agents (Shao & Brown, 2003). Not only phytoestrogens, compounds possessing antioxidant activity are also potential as chemopreventive agents (Seely et al, 2005).…”
Section: Introductionmentioning
confidence: 99%
“…Hormone replacement therapy is the use of exogenous estrogen in order to maintain certain normal functions in the body. The use of phytoestrogens as a replacement of estradiol being used in HRT to decrease cancer risk is then developed, thus categorized as chemopreventive agents (Shao & Brown, 2003). Not only phytoestrogens, compounds possessing antioxidant activity are also potential as chemopreventive agents (Seely et al, 2005).…”
Section: Introductionmentioning
confidence: 99%
“…Ligand-binding experiments revealed high affinity and specific binding of E2 to both ER isotypes, and no obvious differences between the two isotypes alone or combined were observed in ERE transcriptional assays in the presence of E2 [46]. ER-mediated transcription is a highly complex process involving a multitude of coregulatory factors and "cross-talk" between distinct signaling pathways [47,48], which could be depicted in a mode including ligand-dependent and ligand-independent ER transcriptional activations (Figs. 6 and 7) [9,47,2].…”
Section: Estrogen Receptor Transcriptionmentioning
confidence: 99%
“…ER-mediated transcription is a highly complex process involving a multitude of coregulatory factors and "cross-talk" between distinct signaling pathways [47,48], which could be depicted in a mode including ligand-dependent and ligand-independent ER transcriptional activations (Figs. 6 and 7) [9,47,2].…”
Section: Estrogen Receptor Transcriptionmentioning
confidence: 99%
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