Natural Products for Cancer-Targeted Therapy: Citrus Flavonoids as Potent Chemopreventive Agents

Meiyanto, Edy; Hermawan, Adam

doi:10.7314/apjcp.2012.13.2.427

Cited by 209 publications

(151 citation statements)

References 59 publications

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“…Resistance to most of the available anticancer agents such as anthracyclines and taxanes, and its increasing incidence are the foremost obstacle in current breast cancer therapy (Valero and Hortobagyi, 2003;Lodha et al, 2011). This ultimately necessitates an unmet need for novel therapies of breast cancer yet in its advanced malignancy (Kviecinski et al, 2008;Meiyanto et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity, Apoptosis Induction and Anti-Metastatic Potential of Oroxylum indicum in Human Breast Cancer Cells

Ragupathi¹,

George²,

Suresh³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Section: Introductionmentioning

confidence: 99%

Cytotoxicity, Apoptosis Induction and Anti-Metastatic Potential of Oroxylum indicum in Human Breast Cancer Cells

Ragupathi¹,

George²,

Suresh³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…Naringenin protective effects have been widely studied: antioxidant effects (Renugadevi and Prabu 2009), modulation of cytochrome P450 detoxification enzymes (Huong et al 2006), modulation of plasma cholesterol levels (Jeon et al 2007), and antihyperglycemic effects (Jung et al 2004) have been reported. In addition, several experimental data support anticarcinogenic and pro-apoptotic effects of Nar in numerous types of cancer (Arul and Subramanian 2013;Meiyanto et al 2012;Weng and Yen 2012). Most of these effects have been obtained by using variable Nar concentrations ranging from 1 to 100 lM.…”

Section: Introductionmentioning

confidence: 97%

Naringenin modulates skeletal muscle differentiation via estrogen receptor α and β signal pathway regulation

et al. 2014

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Several experiments sustain healthful benefits of the flavanone naringenin (Nar) against chronic diseases including its protective effects against estrogen-related cancers. These experiments encourage Nar use in replacing estrogen treatment in post-menopausal women avoiding the serious side effects ascribed to this hormone. However, at the present, scarce data are available on the impact of Nar on E2-regulated cell functions. This study was aimed at determining the impact of Nar on the estrogen receptor (ERa and b)-dependent signals important for 17b-estradiol (E2) effect in muscle cells (rat L6 myoblasts, mouse C2C12 myoblasts, and mouse skeletal muscle satellite cells). Dietary relevant concentration of Nar delays the appearance of skeletal muscle differentiation markers (i.e., GLUT4 translocation, myogenin, and both fetal and slow MHC isoforms) and impairs E2 effects specifically hampering ERa ability to activate AKT. Intriguingly, Nar effects are specific for E2-initiating signals because IGF-Iinduced AKT activation, and myoblast differentiation markers were not affected by Nar treatment. Only 7 days after Nar stimulation, early myoblast differentiation markers (i.e., myogenin, and fetal MHC) start to be accumulated in myoblasts. On the other hand, Nar stimulation activates, via ERb, the phosphorylation of p38/MAPK involved in reducing the reactive oxygen species formation in skeletal muscle cells. As a whole, data reported here strongly sustain that although Nar action mechanisms include the impairment of ERa signals which drive muscle cells to differentiation, the effects triggered by Nar in the presence of ERb could balance this negative effect avoiding the toxic effects produced by oxidative stress.

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“…Naturally occurring compounds in plants have been shown to inhibit multidrug resistance with minimal side effects (Cragg and Meiyanto et al, 2012). Furthermore, many existing FDA-approved anticancer agents are of natural origin (Saunders and Wallace, 2010).…”

Section: Introductionmentioning

confidence: 99%

Anticancer Activity of Acanthopanax trifoliatus (L) Merr Extracts is Associated with Inhibition of NF-κB Activity and Decreased Erk1/2 and Akt Phosphorylation

Wang

Li²,

Lu³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Acanthopanax trifoliatus (L) Merr (AT) is commonly used as an herbal medicine and edible plant in some areas of China and other Asian countries. AT is thought to have anticancer effects, but potential mechanisms remain unknown. To assess the anticancer properties of AT, we exposed prostate cancer cells to AT extracts and assessed cell proliferation and signaling pathways. An ethanol extract of AT was suspended in water followed by sequential extraction with petroleum ether, ethyl acetate and n-butanol. PC-3 cells were treated with different concentrations of each extract and cell viability was determined by the MTT and trypan blue exclusion assays. The ethyl acetate extract of the ethanol extract had a stronger inhibitory effect on growth and a stronger stimulatory effect on apoptosis than any of the other extracts. Mechanistic studies demonstrated that the ethyl acetate extract suppressed the transcriptional activity of NF-kB, increased the level of caspase-3, and decreased the levels of phospho-Erk1/2 and phospho-Akt. This is the first report on the anticancer activity of AT in cultured human prostate cancer cells. The results suggest that AT can provide a plant-based medicine for the treatment or prevention of prostate cancer.

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Natural Products for Cancer-Targeted Therapy: Citrus Flavonoids as Potent Chemopreventive Agents

Cited by 209 publications

References 59 publications

Cytotoxicity, Apoptosis Induction and Anti-Metastatic Potential of Oroxylum indicum in Human Breast Cancer Cells

Cytotoxicity, Apoptosis Induction and Anti-Metastatic Potential of Oroxylum indicum in Human Breast Cancer Cells

Naringenin modulates skeletal muscle differentiation via estrogen receptor α and β signal pathway regulation

Anticancer Activity of Acanthopanax trifoliatus (L) Merr Extracts is Associated with Inhibition of NF-κB Activity and Decreased Erk1/2 and Akt Phosphorylation

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