Advances in cosmeceutical nanotechnology for hyperpigmentation treatment

Tangau, Mason Jarius; Chong, Yie Kie; Yoon, Yeong Keng

doi:10.1007/s11051-022-05534-z

Cited by 12 publications

(6 citation statements)

References 117 publications

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“…By 2025, it is expected that the market for these skin care products will reach an estimated USD 716 billion [ 7 ]. Maintaining good care of the skin also ensures remarkable esthetic attributes in modern society [ 8 ]. Plant extracts, through their antioxidant effects, can protect the skin from exogenous and endogenous factors [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Unveiling the Antioxidant, Clinical Enzyme Inhibitory Properties and Cytotoxic Potential of Tambourissa peltata Baker—An Understudied Endemic Plant

et al. 2023

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This study documents for the first time the phytochemical composition and biological activities of Tambourissa peltata Baker, an endemic plant from Mauritius. Phytochemical extraction was performed using ethyl acetate, methanol and distilled water as solvents. The phytochemical composition was determined through HPLC-MS and other standard assays. The DPPH, ABTS, FRAP, CUPRAC and phosphomolybdenum assays were employed for the determination of the antioxidant potential, whereas cell viability assays were used to determine the cytotoxicity. The highest phenolic and phenolic acid contents were obtained in the aqueous extract (179.91 ± 0.67 gallic acid equivalents/g and 55.74 ± 1.43 caffeic acid equivalents/g). The highest quantity of flavonoids was obtained in the ethyl acetate extract (28.97 ± 0.46 rutin equivalents/g). The methanolic extract was the highest source of flavonols (33.71 ± 0.13 mg catechin equivalents/g). A total of 34 phytochemicals were identified, mainly proanthocyanidins and flavonoid glycosides. The highest antioxidant activity in DPPH (973.40 ± 5.65 mg TE (Trolox equivalents)/g), ABTS (2030.37 ± 40.83 mg TE/g), FRAP (1461.39 ± 5.95 mg TE/g), CUPRAC (1940.99 ± 20.95 mg TE/g) and phosphomolybdenum (8.37 ± 0.23 mmol TE/g) assays was recorded for the aqueous extract. The ethyl acetate extract was the most active metal chelator. The highest acetylcholinesterase inhibitor was the methanolic extract, whereas the ethyl acetate extract was the most active against BChE. The tyrosinase enzyme was most inhibited by the methanolic extract. Alpha-amylase and glucosidase were most inhibited by the aqueous extract. The methanolic extract was capable of inducing cell cytotoxicity to the human colorectal carcinoma without damaging normal cells. T. peltata warrants further attention from the scientific community given its multifaceted biological properties.

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Section: Introductionmentioning

confidence: 99%

Unveiling the Antioxidant, Clinical Enzyme Inhibitory Properties and Cytotoxic Potential of Tambourissa peltata Baker—An Understudied Endemic Plant

et al. 2023

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“…According to the previous studies, azelaic acid-loaded NLCs was resulted in more occlusive properties, enhanced skin permeation, targeted drug delivery to the melanocytes with enhanced clinical efficacy ( Kumari et al, 2015 ). Moreover, the sustained release capability of azelaic acid-loaded NLCs would be advantageous for topical drug delivery due to the prolonged localized drug deposition within the skin layers ( Tangau et al, 2022 ).…”

Section: New Approaches In Melasma Pharmacotherapymentioning

confidence: 99%

Different therapeutic approaches in melasma: advances and limitations

Ghasemiyeh,

Fazlinejad,

Kiafar

et al. 2024

Front. Pharmacol.

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Melasma is a chronic hyperpigmentation skin disorder that is more common in the female gender. Although melasma is a multifactorial skin disorder, however, sun-exposure and genetic predisposition are considered as the main etiologic factors in melasma occurrence. Although numerous topical and systemic therapeutic agents and also non-pharmacologic procedural treatments have been considered in melasma management, however, the commonly available therapeutic options have several limitations including the lack of sufficient clinical effectiveness, risk of relapse, and high rate of unwanted adverse drug reactions. Recruitment of nanotechnology for topical drug delivery in melasma management can lead to enhanced skin penetration, targeted drug delivery to the site of action, longer deposition at the targeted area, and limit systemic absorption and therefore systemic availability and adverse drug reactions. In the current review, first of all, the etiology, pathophysiology, and severity classification of melasma have been considered. Then, various pharmacologic and procedural therapeutic options in melasma treatment have been discussed. Afterward, the usage of various types of nanoparticles for the purpose of topical drug delivery for melasma management was considered. In the end, numerous clinical studies and controlled clinical trials on the assessment of the effectiveness of these novel topical formulations in melasma management are summarized.

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“…Nanotechnology plays a vital part in the cosmeceutical industry by enhancing the stability, permeability, solubility, safety, and loading capacity of active pharmaceutical ingredients. [74] Hiranphinyophat and his colleagues described a PIPP (poly(2isopropoxy-2-oxo-1,3,2 dioxaphospholane) modified NCs of cellulose for delivery of drugs that are insoluble in water. From the results, it was observed that surface-modified NCs can improve the solubility, efficiency of emulsification, and penetration of drugs in deep skin layers.…”

Section: Hyperpigmentationmentioning

confidence: 99%

Section: Therapeutic Application Of Nanocrystal In Dermatological Com...mentioning

confidence: 99%

Nanocrystals: A Multifaceted Regimen for Dermatological Ailments

Giradkar,

Mhaske,

Shukla

2024

Part & Part Syst Charact

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Skin disorders are the most common apprehension worldwide among different regions of the world. Topical route of administration offers benefits over other routes such as avoidance of first‐pass metabolism, low dose, longer residence time, and absence of off‐target delivery. Skin serves as a mechanical barrier for therapeutic delivery with selectively permeable essential molecules. Considering the structural complexity of skin, delivery of therapeutics at targeted site requires sophisticated method such as nanotechnology‐assisted therapeutic delivery. The roadmap for combinatorial approach of nanotechnology and skin therapeutics has proven significant in clinical and marketed products. Currently, various pharmaceutical aids such as nanocrystal (NCs), nanoparticles, nanoemulsion, nano‐micelles, nano lipidic carriers, and hybrid nanocarriers are currently in market. Among all the other nanocarriers, nanocrystal offers precedence over other nanocarriers due to its facile method of preparation, reproducibility, low excipient concentration, and high therapeutic loading capacity. The recent literature data suggest the breakthrough evolution of NCs in topical therapeutic delivery. The outcome of these interventions envisages the applicability of NCs for delivering molecules with compromised physicochemical characteristics such as solubility, stability, toxicity, and bioavailability concerns.

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Advances in cosmeceutical nanotechnology for hyperpigmentation treatment

Cited by 12 publications

References 117 publications

Unveiling the Antioxidant, Clinical Enzyme Inhibitory Properties and Cytotoxic Potential of Tambourissa peltata Baker—An Understudied Endemic Plant

Unveiling the Antioxidant, Clinical Enzyme Inhibitory Properties and Cytotoxic Potential of Tambourissa peltata Baker—An Understudied Endemic Plant

Different therapeutic approaches in melasma: advances and limitations

Nanocrystals: A Multifaceted Regimen for Dermatological Ailments

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