Advances in Chromatographic Analysis of Tetracyclines in Foodstuffs of Animal Origin—A Review

Samanidou, Victoria F.; Nikolaidou, Konstantina I.; Papadoyannis, Ioannis N.

doi:10.1080/15422110600822758

Cited by 28 publications

(23 citation statements)

References 76 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…They are used to treat gastrointestinal, respiratory, genitourinary and skin bacterial infections as well as infectious diseases of the musculoskeletal system and systemic infections, and also in the treatment of cholera and sepsis (Samanidou et al 2007). However, they have a range of side effects, including disturbances in healthy intestinal microflora, allergic reactions, liver and kidney malfunctions, hypersensitiveness and intense-light related dermatitis.…”

mentioning

confidence: 99%

Effect of pasteurization on the residues of tetracyclines in milk

2014

View full text Add to dashboard Cite

The main aim of this work was to determine the effect of high pasteurization of milk (85 °C/3 s) on the residues of tetracycline and oxytetracycline. The samples of raw cow's milk, purchased from a vending machine, were spiked with standard solutions of tetracycline and oxytetracycline. The content of the residues of tetracycline antibiotics was measured before and after heating. Precleaned samples were extracted by a mixed-mode solid phase extraction technique and analysed using high performance liquid chromatography/diode array detection. Whereas the residues of tetracycline decreased only by 5.74% and were not significantly different (P > 0.05), the residues of oxytetracycline decreased by 15.3% and this distinction was highly significant (P ≤ 0.01). Based on the results of our study, the tetracycline antibiotics were proved to have differences in the thermostability of particular substances at pasteurisation temperatures.

show abstract

mentioning

confidence: 99%

Effect of pasteurization on the residues of tetracyclines in milk

2014

View full text Add to dashboard Cite

show abstract

“…These include amphotericin that binds to the sterol-containing membranes of fungi, polymyxins that act like detergents and disrupt the Gram negative outer membrane and fluconazole and itraconazole that interfere with the biosynthesis of sterol in fungi [34,35].…”

Section: Antimicrobials Acting On the Cell Membranementioning

confidence: 99%

“…(iii) Use at subtherapeutic levels to induce growth promotion is worldwide applied in modern agriculture. The detection, invention, and global uses of antibiotics and antimicrobial agents in human and veterinary medicine, agriculture, and aquaculture have resulted in the survival of resistant microorganisms coupled with the elimination of susceptible ones in antibiotic-containing environments [34,35]. …”

Section: Veterinary Use In Dairy Cowsmentioning

confidence: 99%

See 1 more Smart Citation

Multi‐residue methods for confirmatory determination of antibiotics in milk

Samanidou¹,

Nisyriou²

2008

J of Separation Science

View full text Add to dashboard Cite

The prevalent use of antibiotics, e. g. sulphonamides, tetracyclines, beta-lactams, macrolides, aminoglycosides, etc., in dairy farming to prevent and treat microbial infections e. g. mastitis, can be a potential source of veterinary drug residues in milk. Antibiotic residues constitute a risk to human health, since they can cause allergic reactions in hypersensitive individuals or they may lead to the appearance of drug-resistant bacteria. Analysis of these residues plays a key role in ensuring food safety. Regulatory agencies in the European Union and in other countries have established maximum residue limits and requirements concerning the performance of analytical methods and the interpretation of the results. This review describes the state of the art in the analytical strategies concerning the multi-class as well as the multi-residue analysis of antibiotics in milk. Since milk is a complex matrix due to its high protein and fat content, which often interfere in analytical procedures, special focus has been placed on sample preparation: extraction and clean-up. Confirmation of antibiotic residues according to European Decision 657/2002/EC has been also discussed.

show abstract

“…Відповідно до сучасних вимог з управління безпекою та якістю продуктів тваринного походження необхідно постійно контролювати мікробіологічне обсіменіння харчових продуктів (Dvorska, Fotina, 2011). Встановлено, що сировина тваринного походження часто буває контамінована небезпечною для споживача мікрофлорою (Samanidou, Nikolaidou, 2007;Juan et al, 2010;Wang, Leung, 2007), особливо це стосується м'яса птиці, яке може бути потенційним джерелом харчових токсикоінфекцій і токсикозів (Bilanska, 2009;Melnik, 2007). Мета даної роботи − дослідити мікробіологічні, хімічні та мікроскопічні показники м'яса курчат-бройлерів, вивчити гістологічні зміни у внутрішніх органах птиці у разі використання фармазину і тилоциклінвету під час їх вирощування.…”

unclassified

Вплив Фармазину І Тилоциклінвету На Мікробіологічні, Хімічні Та Мікроскопічні Показники Продуктів Забою Курчат-Бройлерів

Iakubchak

Zabarna²,

Taran

2017

Ukr J Ecol

View full text Add to dashboard Cite

The article deals with the influence of Farmazin® and Tilocyclinvet® on the microbiological, chemical and microscopic characteristics of slaughtering products of broiler chickens. We have been studied the histological changes in the internal organs of broiler chickens under the influence of antibacterial drugs usage. Use of Farmazin and Tilocyclinvet as the antibacterial drugs for broiler chickens did not affect the microflora in the studied samples of poultry meat. We also investigated the microbiological parameters such as mesophilic aerobic and facultative anaerobic microorganisms, Escherichia coli bacteria, Proteus, Salmonella, Listeria monocytogenes, and Staphylococcus aureus bacteria and proved that Farmazin is mostly accumulated in «white» muscle, while Tilocyclinvet -in "red" ones. Results of the chemical analysis shown that the pH of meat in the bird groups that were fed on Farmazin (experimental I), Tilocyclinvet (experimental II) and control groups ranged from 5.64 ± 0.04 to 6.30 ± 0.03. We performed some tests concerning fresh meat and copper sulfate, peroxidase, ammonia and ammonium salts and suggested that meat of broiler chickens from the experimental and control groups con be preserved when refrigerated for three days and it is considered to be fresh. However, on the day 4 of storage pH value of chicken meat in the experimental group increases in the alkaline side; the results of reaction with copper sulfate, ammonium salts, ammonia, and ammonium salts testified the questionable freshness of meat from the experimental group at the end of the withdrawal period. We founded that pH value of broiler chicken meat from experimental group after withdrawal period shifts into the alkaline side comparing to the beginning of withdrawal period. We also registered that pH value of broiler chicken meat from experimental groups shifts into the alkaline side compared to control. Based on histological studies we can say that pathological changes registered in the internal organs of broiler chickens when using Farmazin and Tilocyclinvet were similar to each other and indicated some specific processes. We founded granular and fatty degeneration of hepatocytes, interstitial lymphocytic hepatitis, and fibrosis in the liver of broiler chickens; granular dystrophy of epithelial tubules, diffuse interstitial lymphocytic nephritis, and fibrosis -in kidneys; we also discovered swelling of intramuscular connective tissue and myocardial sclerosis in myocardium. The most obvious pathological changes were observed in broiler chickens, who were fed with Farmazin, somewhat less -in chickens who had got Tilocyclinvet at the beginning of the withdrawal period.

show abstract

Advances in Chromatographic Analysis of Tetracyclines in Foodstuffs of Animal Origin—A Review

Cited by 28 publications

References 76 publications

Effect of pasteurization on the residues of tetracyclines in milk

Effect of pasteurization on the residues of tetracyclines in milk

Multi‐residue methods for confirmatory determination of antibiotics in milk

Вплив Фармазину І Тилоциклінвету На Мікробіологічні, Хімічні Та Мікроскопічні Показники Продуктів Забою Курчат-Бройлерів

Contact Info

Product

Resources

About